Epidemiology and prognosis of childhood cancers at Gabriel-Touré Teaching Hospital (Bamako, Mali)

Togo, Boubacar; Traoré, Fousseyni; Togo, A.; Togo, Pierre; Diakité, A.; B, Traoré; Touré, Abdoulaye; Coulibaly, Yacouba; Traoré, C B; Fenneteau, Odile; Sylla, Fatou K.; Dumke, Henry; Diallo, MT; Diallo, G.; Sidibé, Toumani

doi:10.1684/mst.2014.0291

Cited by 16 publications

(20 citation statements)

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“…The substantial loss to follow-up that we observed is consistent with findings from other cancers in sub-Saharan Africa [ 29 , 30 ], as well as KS specifically. Although the methodologic approaches and metrics vary, reported loss to follow-up for KS at 1 year or less after diagnosis in Africa has ranged from 15 to 23 % [ 18 , 19 , 21 ] and was 26 % at 2 years in another report [ 20 ].…”

Section: Discussionsupporting

confidence: 90%

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

et al. 2016

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BackgroundSurvival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world populations relatively straightforward. In resource-poor settings, given the deficiencies in a variety of health-related data systems, it is less clear how well we can determine cancer survival from ambient data.MethodsWe addressed this issue in sub-Saharan Africa for Kaposi’s sarcoma (KS), a cancer for which incidence has exploded with the HIV epidemic but for which survival in the region may be changing with the recent advent of antiretroviral therapy (ART). From 33 primary care HIV Clinics in Kenya, Uganda, Malawi, Nigeria and Cameroon participating in the International Epidemiologic Databases to Evaluate AIDS (IeDEA) Consortia in 2009–2012, we identified 1328 adults with newly diagnosed KS. Patients were evaluated from KS diagnosis until death, transfer to another facility or database closure.ResultsNominally, 22 % of patients were estimated to be dead by 2 years, but this estimate was clouded by 45 % cumulative lost to follow-up with unknown vital status by 2 years. After adjustment for site and CD4 count, age <30 years and male sex were independently associated with becoming lost.ConclusionsIn this community-based sample of patients diagnosed with KS in sub-Saharan Africa, almost half became lost to follow-up by 2 years. This precluded accurate estimation of survival. Until we either generally strengthen data systems or implement cancer-specific enhancements (e.g., tracking of the lost) in the region, insights from cancer epidemiology will be limited.

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Section: Discussionsupporting

confidence: 90%

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

et al. 2016

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“…The strikingly low incidence of leukaemia in the African regions, notably in sub-Saharan Africa, might give some clues as to the cause of this cancer. Even though strong underdiagnosis of leukaemia is suspected in sub-Saharan Africa, 21 leukaemia was also less commonly diagnosed in black children in the USA than in the other US ethnic groups; however, whether leukaemia might be underdiagnosed as a result of reduced access to health care associated with lower economic status in this group is unclear 22 . In children aged 0–14 years, the highest leukaemia rates were in Hispanic white children in the USA (40% of total incidence).…”

Section: Discussionmentioning

confidence: 99%

International incidence of childhood cancer, 2001–10: a population-based registry study

Steliarova‐Foucher¹,

Colombet²,

Ries³

et al. 2017

The Lancet Oncology

1,128

890

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SummaryBackgroundCancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control.MethodsThis population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s.FindingsOf 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years.InterpretationThis unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research.FundingInternational Agency for Research on Cancer and the Union for International Cancer Control.

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“…Our data are limited by high mortality, which is comparable to other pediatric lymphoma studies across SSA, and LTFU, which is low compared to other studies in the region. 2,22,44,51,52 This may have introduced survivorship bias in observed HRQoL improvements during active treatment and follow-up. However, among the 17 patients who completed surveys at all three timepoints, we observed substantial improvements across all HRQoL domains, except for two patients with relapsed disease.…”

Section: Discussionmentioning

confidence: 99%

Pediatric lymphoma patients in Malawi present with poor health-related quality of life at diagnosis, and improve throughout treatment and follow-up across all Pediatric PROMIS-25 domains.

Ellis¹,

Chapman

Manda³

et al. 2020

Preprint

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Epidemiology and prognosis of childhood cancers at Gabriel-Touré Teaching Hospital (Bamako, Mali)

Cited by 16 publications

References 0 publications

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi’s sarcoma in five countries across sub-Saharan Africa

International incidence of childhood cancer, 2001–10: a population-based registry study

Pediatric lymphoma patients in Malawi present with poor health-related quality of life at diagnosis, and improve throughout treatment and follow-up across all Pediatric PROMIS-25 domains.

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