Epidemiology and prevention of valvular heart diseases and infective endocarditis in Africa

Nkomo, Vuyisile T.

doi:10.1136/hrt.2007.118810

Cited by 107 publications

(78 citation statements)

References 104 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3] However, this trend is not obvious in some developing countries, such as Tunisia and other African states. 4,5 Because only a few studies regarding changes in the clinical presentation or the natural course of IE have application to China, we have attempted to evaluate the clinical presentations and outcomes of IE patients who were surgically treated in our largest national cardiovascular disease referral center over the course of 12 years.…”

Section: A Clinicopathologic Study Of 220 Patients In a Single Medicamentioning

confidence: 99%

Changing Profile of Infective Endocarditis: A Clinicopathologic Study of 220 Patients in a Single Medical Center from 1998 through 2009

Li¹,

Wang²,

Wang³

et al. 2014

Texas Heart Institute Journal

View full text Add to dashboard Cite

The epidemiologic profile of infective endocarditis has changed substantially over the past few years, especially in industrialized countries. Our study evaluates the clinical and pathologic characteristics of infective endocarditis patients treated by cardiac surgery in China during a 12-year period. We retrospectively evaluated 220 surgically treated infective endocarditis patients and analyzed their changes from the beginning of 1998 through 2009. The mean age of the patients increased from 36.9 to 42.7 years during those 12 years (P=0.036). The chief predisposing disease was congenital heart disease (32.8%), rather than rheumatic heart disease (13.2%); this rate did not change significantly during the 12 years. The prevalent congenital lesion was bicuspid aortic valve, the rate of which (55.6%) increased significantly over the 3 time intervals studied (P=0.016). The frequency of infective endocarditis after non-dental surgical and nonsurgical intervention was significantly greater (23.3%) during 1998 through 2001, compared with the 2 intervals that followed (9%; P=0.019). Streptococcus viridans was the most frequent causative agent overall (25.6%). Forty-seven of the 220 patients (21.4%) carried the clinical diagnosis of some other form of heart disease before surgery, but at surgery they were found to have infective endocarditis as the fundamental disease process. Of 47 patients, 33 (70.2%) had either very small or no vegetations but had focal necrosis and inflammation of valve tissue that supported the diagnosis of infective endocarditis.

show abstract

Section: A Clinicopathologic Study Of 220 Patients In a Single Medicamentioning

confidence: 99%

Changing Profile of Infective Endocarditis: A Clinicopathologic Study of 220 Patients in a Single Medical Center from 1998 through 2009

Li¹,

Wang²,

Wang³

et al. 2014

Texas Heart Institute Journal

View full text Add to dashboard Cite

show abstract

“…(9) The highest prevalence rate of 19.2/1 000 was reported for Grade 7 pupils, but their age group was not specified. (9,15) In 1984 a survey was conducted in Inanda in KwaZulu-Natal.…”

Section: Winter 2015mentioning

confidence: 99%

The prevalence of rheumatic heart disease among Grade 10 - 12 learners in the Free State and Northern Cape – Preliminary results of the Wheels-of-Hope Outreach Programme

Smit

Botes

Rossouw

et al. 2017

SAHJ

View full text Add to dashboard Cite

show abstract

“…(67)(68)(69) Mitral balloon valvotomy is preferred for severe mitral stenosis with pliable leafl ets and without heavy commissural calcifi cation, (68) (71) but is an uncommon indication for mitral valve surgery in surgical series reported from Africa. (6) Valve diseases related to aging are the most common form of valve diseases in developed countries, (72) and are also encountered in the elderly in Africa. (73) However, age-related valve diseases of clinical signifi cance were not part of the spectrum of heart disease and risk factors in a recent cohort study of a large black urban population in Soweto, South Africa.…”

Section: Valve Diseasesmentioning

confidence: 99%

Epidemiology of valvular heart diseases in Africa

Nkomo

2017

SAHJ

View full text Add to dashboard Cite

The current understanding of the pathogenesis RF is that RF is the result of a delayed immune response to Group A B-haemolytic streptococcus (GABHS) pharyngitis after a latent period ranging from 1-5 weeks.(8) Our understanding of this current working paradigm is based on epidemiologic and experimental data largely from the United States (9,10) more than half a century ago when RF and RHD were still a major public health problem there. Rheumatic fever rarely affects adults and occurs mainly in children in the age group 5-15 years. (11,12) About 3% of GABHS pharyngitis cases will develop RF of left untreated, but the risk of RF increases substantially to about 75% with a recurrent episode of GABHS pharyngitis. (13)(14)(15) The precise pathogenic mechanism of RF has not been fully defi ned.

show abstract

Epidemiology and prevention of valvular heart diseases and infective endocarditis in Africa

Cited by 107 publications

References 104 publications

Changing Profile of Infective Endocarditis: A Clinicopathologic Study of 220 Patients in a Single Medical Center from 1998 through 2009

Changing Profile of Infective Endocarditis: A Clinicopathologic Study of 220 Patients in a Single Medical Center from 1998 through 2009

The prevalence of rheumatic heart disease among Grade 10 - 12 learners in the Free State and Northern Cape – Preliminary results of the Wheels-of-Hope Outreach Programme

Epidemiology of valvular heart diseases in Africa

Contact Info

Product

Resources

About