Epidemiology and Pathophysiology of Mitral Valve Prolapse

Delling, Francesca N.; Vasan, Ramachandran S.

doi:10.1161/circulationaha.113.006702

Cited by 236 publications

(153 citation statements)

References 105 publications

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“…11,12 It can be defined as a $2-mm superior displacement of the mitral valve leaflets into the left atrium during systole. 15 MVP is considered the most common primary valvular abnormality in young populations (prevalence 2% to 5%), 16,17 and it is often associated with heritable connective tissue disorders. 4,15,18 It is usually a benign asymptomatic condition, although it is also related to a confusing array of seemingly unrelated symptoms of dysautonomia that cannot be explained on the basis of mitral regurgitation alone, such as palpitations, orthostatic hypotension, syncope fatigue-exercise intolerance, chest pain, shortness of breath, and panic attacks, which are collectively called MVP syndrome.…”

Section: Discussionmentioning

confidence: 99%

Chest Pain in Children With Suspected Type I Fibrillinopathy: A Case Report

et al. 2015

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Chest pain is the second most common reason for referral to a pediatric cardiologist, because cardiovascular-related disorders are a major concern for children and their families when seeking medical attention. On the rare occasions when pediatric chest pain is a result of severe heart disease, it is usually associated with well-known cardiovascular risk factors such as fibrillinopathies. Type 1 fibrillinopathies are heritable disorders caused by mutations in the fibrillin genes that lead to a broad spectrum of connective tissue phenotypes ranging from Marfan syndrome, at the most severe end, to patients displaying mild marfanoid features, or milder Marfan (MM). We report the case of an adolescent patient with MM and suspected acute coronary syndrome, with chest pain and electrocardiographic changes suggestive of myocardial ischemia. Despite the low risk of coronary or aortic dissection/aneurysm in MM, these possibilities should be tested. Once they are ruled out, mitral valve prolapse should be considered as the main cause of chest pain with ischemic-like changes in the inferior electrocardiogram leads. We emphasize that clinical and echocardiographic follow-up over years is warranted in the pediatric population to ensure that the aortic root does not show progressive dilatation or a tendency to dissect. Finally, genotyping is clinically indicated for early and complete diagnosis in patients with MM as well as de novo Marfan syndrome to take advantage of educational and clinical programs for young carriers of the mutation.

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Section: Discussionmentioning

confidence: 99%

Chest Pain in Children With Suspected Type I Fibrillinopathy: A Case Report

et al. 2015

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“…33 By the 6th decade of life, the prevalence of significant mitral valve disease within the U.S. population is estimated to be greater than 6% and rises steadily thereafter. 1,17,51 As such there is intense interest within the clinical and engineering communities to develop optimal technologies to address this increasing disease burden. Several decades of surgical advances, improvements in functional imaging and materials development have revealed several important principals for successful restoration of mitral valve function.…”

Section: Introductionmentioning

confidence: 99%

Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

et al. 2014

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Abstract-In this portion of an extensive review of heart valve engineering, we focus on the current and emerging technologies and techniques to repair or replace the mitral valve. We begin with a discussion of the currently available mechanical and bioprosthetic mitral valves followed by the rationale and limitations of current surgical mitral annuloplasty methods; a discussion of the technique of neo-chordae fabrication and implantation; a review the procedures and clinical results for catheter-based mitral leaflet repair; a highlight of the motivation for and limitations of catheterbased annular reduction therapies; and introduce the early generation devices for catheter-based mitral valve replacement.

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“…Не-смотря на это, данная патология до конца не изучена и остается много вопросов в отношении методов лечения [4]. Высокая распространенность пролапса МК во всем мире [5], и в частности в нашей стране [6], является по-водом для пристального внимания в отношении методов лечения данного состояния.…”

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Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chords

Makogonchuk¹,

Евтушенко²,

Евтушенко³

2018

Sib. med. ž. (Tomsk)

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Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук, 634012, Российская Федерация, Томск, ул. Киевская, 111аCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 111а, Kievskaya str., Тоmsk, 634012, Russian Federation В данной статье приводится обзор современных методик лечения пролапса митрального клапана вследствие деге-нерации. Медикаментозное лечение пациентов с пролапсом митрального клапана малоэффективно. Предпочтение в данном случае следует отдать хирургическому лечению. Показано, что при выборе тактики вмешательства важно учитывать не только наличие самой патологии, но и исходное функциональное состояние элементов подклапан-ного аппарата. Так, среди методов хирургического лечения протезирование клапана при данной патологии имеет значительные недостатки по сравнению с реконструктивной хирургией. Показано разнообразие техник пластики митрального клапана. Представлены преимущества и недостатки каждого из методов. Ключевые слова: хирургическое лечение пролапса митрального клапана, разнообразие техник пластики ми-трального клапана Конфликт интересов: авторы заявляют об отсутствии конфликта интересов Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах Для цитирования: Макогончук И. С., Евтушенко В. В., Евтушенко А. В. Клинические и фундаментальные аспекты протезирования и транслокации хорд митрального клапана. Сибирский медицинский журнал. 2018; 33(1): 27-32. DOI: 10.29001/2073DOI: 10.29001/ -8552-2018 This article provides an overview of modern methods of treating prolapse of the mitral valve due to degeneration. Medical treatment of patients with mitral valve prolapse is ineffective. Preference in this case should be given to the surgical treatment. It is shown that while choosing tactics of intervention it is important to take into account not only the presence of the pathology itself, but also the initial functional state of the elements of the subvalvular apparatus. So, among the methods of surgical treatment, valve prosthesis in this pathology has significant disadvantages in comparison with reconstructive surgery. A variety of techniques for mitral valve plastic are shown. The advantages and disadvantages of each method are presented. Keywords: surgical treatment of mitral valve prolapse, a variety of mitral valve plastic techniques Conflict of interest: the authors do not declare a conflict of interest Financial disclosure: no author has a financial or property interest in any material or method mentioned Недостаточность митрального клапана (МК) -наи-более распространенный порок сердца в Европе [1], зо-лотым стандартом коррекции которого признана много-компонентная реконструкция клапана [2]. Важнейший компонент подобных операций -коррекция длины хорд клапана, наиболее распространенными разновид-ностями которой являются протезирование хорд син-тетическими материалами и использование аутохорд и аутоство...

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Epidemiology and Pathophysiology of Mitral Valve Prolapse

Cited by 236 publications

References 105 publications

Chest Pain in Children With Suspected Type I Fibrillinopathy: A Case Report

Chest Pain in Children With Suspected Type I Fibrillinopathy: A Case Report

Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chords

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