Epidemiology and Pathogenesis of Gallstones

Cao, Amy M.; Eslick, Guy D.

doi:10.1007/978-3-319-63884-3_3

Cited by 11 publications

(12 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 14 15 The risk factors for GSD include old age, female sex, ethnicity, pregnancy, family history, sedentary lifestyle, obesity and weight gain. 7 Diet is a major lifestyle factor that plays a vital role in GSD causal network. Various studies have shown a link between GSD and dietary factors such as high-calorie intake, low consumption of fiber-rich foods, vegetables and fruits, hypertriglyceridaemia, and high consumption of refined carbohydrates and polyunsaturated and monounsaturated fats.…”

Section: Introductionmentioning

confidence: 99%

Association between the Dietary Inflammatory Index with gallstone disease: finding from Dena PERSIAN cohort

Sadri

Harouni

Vahid

et al. 2022

BMJ Open Gastroenterol

View full text Add to dashboard Cite

ObjectiveThe Dietary Inflammatory Index (DII) is a documented nutritional tool for assessing diet-induced inflammation that has been linked to various diseases/outcomes. The association between DII and gallstone disease (GSD) is yet to be explored. The objective of this study was to examine the association between DII and GSD.DesignThis cross-sectional study was conducted using the baseline phase data of the Dena PERSIAN cohort. The analysed data included demographic information, lifestyle variables, body mass index, diabetes and fatty liver history, and laboratory test results. The 113-item Food Frequency Questionnaire was used to estimate the dietary intake of participants and quantify the inflammatory potential of the individual’s diet. DII score was analysed as a continuous and quartiles variables. Univariable and multivariate logistic regressions were used to investigate the relationship between GSD and DII scores .ResultsOut of 3626 individuals entering the study, 173 (4.77%) had GSD. The median DII was −0.08 (IQR=0.18). In the unadjusted model, the odds of having GSD were significantly higher in the first and second quartiles of DII (anti-inflammatory diet) than in higher quartiles (proinflammatory diet). In the adjusted model, the odds of having GSD in the third and fourth quartiles of DII scores compared with the first quartile were OR=0.59 (95% CI 0.36 to 0.95) and OR 0.51 (95% CI 0.30 to 0.84), respectively.ConclusionThe results of this study suggest that a proinflammatory diet is associated with a reduced chance of GSD. However, longitudinal studies are needed to examine the causal association.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between the Dietary Inflammatory Index with gallstone disease: finding from Dena PERSIAN cohort

Sadri

Harouni

Vahid

et al. 2022

BMJ Open Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Gallstone-related disease was the commonest cause of hospital admissions in the developed world at the beginning of the 21st Century ( 1 , 2 ). In developed nations, gallstones affect 10–20% of adults ( 3 – 5 ), of whom 80% are asymptomatic ( 5 , 6 ). The remainder can present with anything from biliary colic, cholecystitis, cholangitis, choledocholithiasis (i.e., common bile duct [CBD] stones) and gallstone pancreatitis ( 7 – 11 ), to rarer severe variants such as Mirizzi's syndrome, gangrenous, haemorrhagic, or emphysematous cholecystitis.…”

Section: Introduction and Objectivesmentioning

confidence: 99%

Cholecystectomy for Complicated Gallbladder and Common Biliary Duct Stones: Current Surgical Management

et al. 2020

View full text Add to dashboard Cite

Gallstone disease accounts for the vast majority of acute surgical admissions in the UK, with a major treatment being cholecystectomy. Practice varies significantly as to whether surgery is performed during the acute symptomatic phase, or after a period of recovery. Differences in practice relate to operative factors, patient factors, surgeon factors and hospital and trust wide policies. In this review we summarize recent evidence on management of gallstone disease, particularly with respect to whether cholecystectomy should occur during index presentation or following recovery. We highlight morbidity and mortality studies, cost, and patient reported outcomes. We speculate on barriers to change in service delivery. Finally, we propose potential solutions to optimize care.

show abstract

“…A variety of mechanisms stand behind the pathophysiology of gallstones such as bile super-saturation, alteration of bile composition, gallbladder mucus overproduction, biliary stasis, and decreased gallbladder motility [23] , [24] .…”

Section: Discussionmentioning

confidence: 99%

Pearl-white gallstones: A report of a case and a chemical analysis by FTIR and XRD

Dowais

Sharie

Araydah

et al. 2021

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

Introduction Gallstones' color is usually yellow, brown, black or more commonly a mixture of two or more of these colors in different proportions, depending on their composition, with yellow being the most commonly encountered color. Pearl-white gallstones are a very rare entity that has not been studied and reported sufficiently. Case presentation Our patient is a 44-year-old lady who was suffering from recurrent attacks of epigastric and right hypochondrial abdominal pain that was aggravated by consumption of fatty meals. Ultrasound Imaging revealed multiple gallbladder stones. After an elective cholecystectomy unusual pearl-white gallstones were found inside a distended gallbladder filled with transparent thick fluid. Chemical analysis To evaluate the chemical composition of these stones Fourier-transform infrared (FTIR) spectroscopy and X-Ray Diffraction (XRD) tests were performed and revealed that these stones are composed of cholesterol (99.6%) and calcium carbonate (0.4%). Discussion Gallstones are bile depositions of a solid consistency formed inside the gallbladder. Cholesterol, bilirubin, and other substances are involved in the composition of different kinds of gallstones. The presence of gallstones alone inside the gallbladder is usually presented as colicky abdominal pain. Cholecystectomy is a simple surgical removal of the gallbladder from it bed and is the definitive treatment of gallstone disease. Conclusion Pearl-white gallstones are rarely encountered and lack information about their pathogenesis, thus prompting further evaluation and studying.

show abstract

Epidemiology and Pathogenesis of Gallstones

Cited by 11 publications

References 51 publications

Association between the Dietary Inflammatory Index with gallstone disease: finding from Dena PERSIAN cohort

Association between the Dietary Inflammatory Index with gallstone disease: finding from Dena PERSIAN cohort

Cholecystectomy for Complicated Gallbladder and Common Biliary Duct Stones: Current Surgical Management

Pearl-white gallstones: A report of a case and a chemical analysis by FTIR and XRD

Contact Info

Product

Resources

About