Epidemiology and Outcomes of SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome in Children vs Influenza Among Critically Ill Children

Shein, Steven L.; Carroll, Christopher L.; Remy, Kenneth E.; Rogerson, Colin; McCluskey, Casey K.; Lin, Anna; Rotta, Alexandre T.

doi:10.1001/jamanetworkopen.2022.17217

Cited by 7 publications

(5 citation statements)

References 6 publications

(16 reference statements)

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“…data, https://doi.org/10.1101/2023.08.28.23294732 ). This increase probably reflected both ongoing transmission of SARS-CoV-2 and the greater clinical severity of COVID-19 infection among children compared with influenza, as demonstrated by both higher rates of hospitalization and higher rates of intensive care unit admission among those < 18 years of age ( 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our ). This increase probably reflected both ongoing transmission of SARS-CoV-2 and the greater clinical severity of COVID-19 infection among children compared with influenza, as demonstrated by both higher rates of hospitalization and higher rates of intensive care unit admission among those <18 years of age (17,18). The most frequently documented reason for closure in both school years was COVID-19 cases in the school or school district.…”

Section: Discussionmentioning

confidence: 99%

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COVID-19–Related School Closures, United States, July 27, 2020–June 30, 2022

Zviedrite,

Jahan,

Moreland

et al. 2024

Emerg. Infect. Dis.

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As part of a multiyear project that monitored illness-related school closures, we conducted systematic daily online searches during July 27, 2020–June 30, 2022, to identify public announcements of COVID-19–related school closures (COVID-SCs) in the United States lasting > 1 day. We explored the temporospatial patterns of COVID-SCs and analyzed associations between COVID-SCs and national COVID-19 surveillance data. COVID-SCs reflected national surveillance data: correlation was highest between COVID-SCs and both new PCR test positivity (correlation coefficient [r] = 0.73, 95% CI 0.56–0.84) and new cases (r = 0.72, 95% CI 0.54–0.83) during 2020–21 and with hospitalization rates among all ages (r = 0.81, 95% CI 0.67–0.89) during 2021–22. The numbers of reactive COVID-SCs during 2020–21 and 2021–22 greatly exceeded previously observed numbers of illness-related reactive school closures in the United States, notably being nearly 5-fold greater than reactive closures observed during the 2009 influenza (H1N1) pandemic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID-19–Related School Closures, United States, July 27, 2020–June 30, 2022

Zviedrite,

Jahan,

Moreland

et al. 2024

Emerg. Infect. Dis.

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“…The large increase in illness-related closures during SYs 2020-21 and 2021-22, which was nearly 5-fold higher than those observed during severe influenza seasons, including the 2009 H1N1 Pandemic (H1N1pdm09 virus) (14) and subsequent moderate and severe influenza seasons (namely 2017-18, 2018-19, and 2019-20), was nearly fully attributed to COVID-19 (15). This increase likely reflected both ongoing transmission of SARS-CoV-2 and the greater clinical severity of COVID-19 infection among children as compared to influenza, as demonstrated by both higher rates of hospitalization and higher rates of ICU admission among those 18 and younger (16, 17).…”

Section: Discussionmentioning

confidence: 99%

COVID-19-related school closures, United States, July 27, 2020 – June 30, 2022

Zviedrite,

Jahan,

Moreland

et al. 2023

Preprint

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As part of a multi-year project that monitored illness-related school closures, we conducted systematic daily online searches from July 27, 2020–June 30, 2022, to identify public announcements of COVID-19-related school closures (COVID-SCs) in the US lasting ≥1 day. We explored the temporospatial patterns of COVID-SCs and analyzed associations between COVID-SCs and national COVID-19 surveillance data. COVID-SCs reflected national surveillance data: correlation was highest between COVID-SCs and both new PCR test positivity (correlation coefficient, r = 0·73, CI: 0·56, 0·84) and new cases (r = 0·72, CI: 0·54, 0·83) in school year (SY) 2020-21, and with hospitalization rates among all ages (rs = 0·81, CI: [0·67, 0·89]) in SY 2021-22. The number of reactive COVID-SCs during SYs 2020-21 and 2021-22 greatly exceeded previously observed numbers of illness-related reactive school closures in the US, notably being nearly 5-fold greater than reactive closures observed during the 2009 H1N1 Pandemic (H1N1pdm09 virus).Article summary lineCOVID-19-related school closures occurred annually in the US and their temporal patterns mirror the general patterns of COVID-19 activity at the national level as observed through routine COVID-19 epidemiological surveillance.

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“…Early reports that children were relatively unaffected in COVID, and that the virus was "just the flu" by "social media experts" have been disproven (8)(9)(10).…”

mentioning

confidence: 99%

“…Early reports that children were relatively unaffected in COVID, and that the virus was “just the flu” by “social media experts” have been disproven (8–10). Children have demonstrated varying outcomes with acute COVID, multisystem inflammatory syndrome, and long-term COVID sequelae (11).…”

mentioning

confidence: 99%