Epidemiology and outcomes of gastrointestinal mucosal melanomas: a national database analysis

Shah, Niraj James; Aloysius, Mark M.; Bhanat, Eldrin; Gupta, Shweta; Aswath, Ganesh; John, Savio; Tang, Shou‐jiang; Goyal, Hemant

doi:10.1186/s12876-022-02254-5

Cited by 3 publications

(5 citation statements)

References 40 publications

(26 reference statements)

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“…In this study, adjuvant treatment did not affect the prognosis of PGIM, consistent with other studies 8 26. However, these findings must be interpreted with caution for the SEER database does not contain information on somatic mutations and specific treatment regimens, hence, it is difficult to perform further subgroup analysis of the data.…”

Section: Discussionsupporting

confidence: 86%

Prognostic models based on lymph node density for primary gastrointestinal melanoma: a SEER population-based analysis

Zeng,

Zhu,

Zhou

et al. 2023

BMJ Open

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ObjectiveThis study aimed to construct prognostic models to predict the overall survival (OS) and cancer-specific survival (CSS) of patients with primary gastrointestinal melanoma (PGIM).DesignAn observational and retrospective study.SettingData were obtained from the Surveillance, Epidemiology and End Results (SEER) programme database, encompassing a broad geographical and demographic spectrum of patients across the USA.ParticipantsA total of 991 patients diagnosed with PGIM were included in this study.MethodsA total of 991 patients with PGIM were selected from the SEER database. They were further divided into a training cohort and a validation cohort. Independent prognostic factors were identified by Cox regression analysis. Two prognostic models were constructed based on the results of multivariable Cox regression analysis. The concordance index (C-index) and area under the time-dependent receiver operating characteristic curve (time-dependent AUC) were used to evaluate the discriminative ability. Calibration curves were plotted to evaluate the agreement between the probability as predicted by the models and the actual probability. Risk stratification was developed given the model.ResultsBy the multivariable Cox regression analysis, we identified four independent risk factors (age, stage, lymph node density and surgery) for OS, and three independent risk factors (stage, lymph node density and surgery) for CSS, which were used to construct prognostic models. C-index, time-dependent AUC, calibration curves and Kaplan-Meier curves of risk stratification indicated that these two models had good discriminative ability, predictive ability as well as clinical value.ConclusionsThe prognostic models of OS and CSS had satisfactory accuracy and were of clinical value in evaluating the prognosis of patients with PGIM.

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Section: Discussionsupporting

confidence: 86%

Prognostic models based on lymph node density for primary gastrointestinal melanoma: a SEER population-based analysis

Zeng,

Zhu,

Zhou

et al. 2023

BMJ Open

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“…Surgery for anorectal lesions revealed better outcomes with 33.6% 5-year survival rate, according to studies. 19 WLE is the procedure of choices for many surgeons, followed by adjuvant radiotherapy, which leads to similar local result, with less perioperative morbidity as the radical surgery. 34 For the locally advanced or metastatic disease, palliative surgery with partial resection with or without diverting colostomy is performed.…”

Section: Discussionmentioning

confidence: 99%

“…18 The overall survival by primary site of mucosal melanoma showed a better rate for patients with an overlapping lesion of the rectum and anal canal (50%), when compared to large bowel, gall bladder, esophagus, and the pancreas. 19 The main reasons of the delayed diagnosis are the late and nonspecific symptoms of patients with anorectal melanomas when the tumor size exceed 4 cm.…”

Section: Discussionmentioning

confidence: 99%

“…The overall survival by primary site of mucosal melanoma showed a better rate for patients with an overlapping lesion of the rectum and anal canal (50%), when compared to large bowel, gall bladder, esophagus, and the pancreas. 19 …”

Section: Discussionmentioning

confidence: 99%

“…Surgery for anorectal lesions revealed better outcomes with 33.6% 5-year survival rate, according to studies. 19 …”

Section: Discussionmentioning

confidence: 99%

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Primitive rectal melanoma: A rare case report

Elouali,

Imrani,

Berrada

et al. 2023

SAGE Open Medical Case Reports

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Mucosal melanoma is a rare subtype of melanoma distinct from the cutaneous type in its clinical and biological aspects, requiring different therapeutical management. Anorectal melanomas represent less than 1% of anorectal cancers and 0.3% of malignant melanomas, and they are by far the most studied type. Proctologic examination, colonoscopy, and biopsy can establish a correct diagnosis. Imaging techniques, especially MRI can show some characteristic features, but it is essentially performed for extension assessment. We report the case of a 63-year-old man who consulted for rectal bleeding. The proctological examination found a brownish ulcerative-vegetating tumor of 3 cm in diameter located 3 cm from the anal rim. The endoscopic examination revealed a predominance of ulcerative budding lesions and the biopsy specimen confirmed a rectal melanoma. The extension assessment, based on a computed tomography scan and MRI did not show locoregional or distant metastases. Radiotherapy and abdominoperineal resection with pelvic node dissection was the treatment of choice with good evolution.

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