Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China

Zhou, Jialing; Qian, Chuanyun; Zhao, Mingyan; Yu, Xiangyou; Kang, Yan; Ma, Xiaochun; Ai, Yuhang; Xu, Yuan; Liu, Dexin; An, Youzhong; Wu, Dawei; Sun, Renhua; Li, Shusheng; Hu, Zhenjie; Cao, Xiangyuan; Zhou, Fachun; Jiang, Li; Lin, Jiandong; Mao, Enqiang; Qin, Tiehe; Zhen-yang, HE; Zhou, Ling; Du, Bin

doi:10.1371/journal.pone.0107181

Cited by 170 publications

(159 citation statements)

References 33 publications

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“…Similar to these results, Zhou et al (7) showed that among patient with severe sepsis and septic shock, Gram-negative organisms ranked the highest (62.5%), followed by Grampositive organisms (14.5%) and fungi (2.2%), respectively. Since mainland China lacks the national investigation of the pathogen of sepsis, it may vary in different districts and ICU wards.…”

Section: Pathogensupporting

confidence: 57%

“…Among the 3,665 patients admitted to ICU, 318 developed severe sepsis, i.e., 8.68% of the total population. Another prospective, observational cohort study conducted in 22 ICUs from July 2009 to August 2009 reported that among 1,297 patients enrolled, 484 (37.3%) developed severe sepsis and septic shock (7). Both of the studies used the American College of Chest Physicians/Society of Critical Care Medicine consensus criteria to define severe sepsis.…”

Section: Incidence Of Icu-treated Sepsismentioning

confidence: 99%

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Current epidemiology of sepsis in mainland China

Liao

et al. 2016

Ann. Transl. Med.

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The disease burden of sepsis is a global issue. Most of the large-scale epidemiological investigations on sepsis have been carried out in developed countries. The population of 1.3 billion in mainland China accounts for approximately 1/5 th of the whole world population. Thus, the knowledge of the incidence and mortality of sepsis in mainland China is vital before employing measures for its improvement. However, most of the epidemiological data of sepsis in mainland China was obtained from ICU settings, and thus lacks the population-based incidence and mortality of sepsis. In the present review, we summarized the limited literature encompassing the incidence, mortality, long-term outcome, and pathogens of sepsis in mainland China. Therefore, it might provide some valuable information regarding the sepsis disease burden and current issues in the management of sepsis in mainland China.

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Section: Pathogensupporting

confidence: 57%

Section: Incidence Of Icu-treated Sepsismentioning

confidence: 99%

Current epidemiology of sepsis in mainland China

Liao

et al. 2016

Ann. Transl. Med.

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“…A recent meta‐analysis of RCTs reported that the survival benefit of anticoagulant therapy was observed only in sepsis patients with DIC, but not in those without DIC 10. Furthermore, although many epidemiological studies for sepsis have been carried out,11, 12, 13, 14, 15 epidemiological data regarding sepsis in Japan is limited 16, 17…”

Section: Introductionmentioning

confidence: 99%

A summary of the Japan septic disseminated intravascular coagulation study

Hayakawa

Ono

2018

Acute Medicine & Surgery

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Over the past few decades, the large, international, randomized controlled trials of anticoagulant therapies for patients with sepsis have not yielded any improvement in mortality rates. However, in Japan, anticoagulant therapies are administered for sepsis patients with disseminated intravascular coagulation (DIC), but not for sepsis patients without DIC. Furthermore, epidemiological data regarding sepsis in Japan are scarce. Therefore, a nationwide multicenter retrospective observational study, the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study, was undertaken. The JSEPTIC DIC study enrolled 42 intensive care units and included 3,195 patients with sepsis. The results of the JSEPTIC DIC study indicated the following: (i) anticoagulant therapy may be effective in sepsis‐induced DIC patients at high risk for death, (ii) recombinant human soluble thrombomodulin administration and antithrombin supplementation are associated with survival benefits in patients with sepsis‐induced DIC.

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“…Several studies have described the epidemiology, risk factors, and outcomes of sepsis (1)(2)(3)(4) . However, why some patients recover from sepsis while others do not remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Between 6 and 54% of the patients admitted to ICUs have severe sepsis, and the mortality rate for these patients varies from 20 to 60%, which increases stepwise with increasing disease severity. Several studies have described the epidemiology, risk factors, and outcomes of sepsis, severe sepsis, and septic shock (1)(2)(3)(4) . However, why some patients recover from sepsis while others do not, remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Mortality Predictors in General Intensive Care Unit Patients with Nosocomial Sepsis: A Retrospective Cohort Study

Çalık¹,

Arı²,

Avcı³

et al. 2017

Terh

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Objective: Nosocomial sepsis is among the major factors contributing to mortality in intensive care units (ICUs). Mortality predictors in general ICU patients with nosocomial sepsis were investigated. Methods: This retrospective cohort study was conducted between January 1, 2013 and May 1, 2014 in two general ICUs of a training and research hospital. In total, 95 sepsis attacks developing in 83 patients were included in the study. Data from patients' medical records were recorded on standardised forms. Results: Sepsis was detected in 21.2 cases per 100 ICU admissions. The median length of ICU stay was 37.56±39.595 (range, 1-173) days. Study population consisted of 43 (51.8%) male and 40 (48.2%) female patients. Their ages ranged from 18 to 90 (mean, 69±15.753) years. The median APACHE II score was 26. 9±6.4 (range, 15-45). The primary reasons for admission were medical problems in 62 (74.7%), elective surgeries in 13 (15.7%), and emergency surgeries in 10 (12.8%) patients. Pneumonia (80%) accounted for the majority of nosocomial cases of sepsis detected in the ICUs. Pseudomonas aeruginosa (24.6%), Acinetobacter baumannii (24.6%), and Klebsiella pneumoniae (18.5%) were the most frequently isolated microorganisms. Rate of mortality secondary to nosocomial sepsis was 41 percent. In conclusion, multivariate logistic regression showed that emergency surgery (p=0.004), an increase in the SOFA score (p=0.001), and haemodialysis required for acute renal failure (p=0.004) were statistically significant risk factors for mortality due to nosocomial sepsis. Conclusions: Monitoring SOFA scores may be useful for the monitorization of the patients with nosocomial sepsis.

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Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China

Cited by 170 publications

References 33 publications

Current epidemiology of sepsis in mainland China

Current epidemiology of sepsis in mainland China

A summary of the Japan septic disseminated intravascular coagulation study

Investigation of Mortality Predictors in General Intensive Care Unit Patients with Nosocomial Sepsis: A Retrospective Cohort Study

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