Epidemiology and outcome of cervical cancer in national institute of Morocco

Abstract

BackgroundOn behalf of the medical staff of the National Institute of Oncology of Rabat, we conducted a retrospective study to report epidemiology and 5-year outcomes of cervical carcinoma in Moroccan women.MethodsWe reviewed all women diagnosed with invasive cervical carcinoma in our institute between January 2006 and December 2006. Outcomes and prognoses are analyzed in patients who received at least one treatment.ResultsThe analysis included 646 women. Median age was 50 years (23–85 years). Bleeding was the most frequent symptom (95 %). The most predominant histology was squamous cell carcinoma (94 %). The majority of patients were diagnosed at locally advanced stages (88 %). Among patients who received treatment (n = 550), the management was based on concurrent chemoradiotherapy in 69.7 % of cases. The median duration of follow-up was 60 months (range 2–78 months). Overall survival, progression free survival, and locoregional recurrence free survival were 63.2, 60.7 and 79.1 % respectively. Significant poor prognostic factors in univariate analysis included stage, tumor size, lymph node involvement, anemia and absence of response to radiotherapy. The prognostic significance of response to radiotherapy and stage were retained in multivariate analysis.ConclusionCervical cancer in our Institute is diagnosed at locally advanced stages. Two third of patients were treated by concurrent chemoradiotherapy. Outcome of Moroccan patients are comparable to that of western countries. Significant prognostic factors were stage, tumor size, lymph node involvement, anemia, and response to radiotherapy. The way to reduce the global burden of cervical cancer in our country continues to be the development of vaccination and screening programs.Electronic supplementary materialThe online version of this article (doi:10.1186/s12905-016-0342-2) contains supplementary material, which is available to authorized users.

Cervical cancer survival in sub‐Saharan Africa by age, stage at diagnosis and Human Development Index: A population‐based registry study

“…Cervical cancer is the most common cause of cancer death in African women. 1 Women with cervical cancer in sub-Saharan Africa (SSA) are frequently diagnosed at advanced stages [2][3][4] , have poor access to appropriate diagnosis and treatment 5 and have prolonged treatment waiting times 6 leading to poor survival outcomes. 5 Several observational cohort and case-series studies have described the poor survival in women with cervical cancer in SSA, 3,4,6 however, these estimates are not always generalizable to the population at large.…”

“…1 Women with cervical cancer in sub-Saharan Africa (SSA) are frequently diagnosed at advanced stages [2][3][4] , have poor access to appropriate diagnosis and treatment 5 and have prolonged treatment waiting times 6 leading to poor survival outcomes. 5 Several observational cohort and case-series studies have described the poor survival in women with cervical cancer in SSA, 3,4,6 however, these estimates are not always generalizable to the population at large. Survival is the complex result of several factors such as the availability of screening programmes, socioeconomic factors, stage at diagnosis, availability of treatment infrastructure and health personnel to give timely and appropriate care [4][5][6] and co-morbidities such as HIV.…”

Cervical cancer prevention in Morocco: a model-based cost-effectiveness analysis

“…In Morocco, opportunistic cervical cancer screening based on VIA every 3 years in women aged 30-49 was launched in 2010 7,8 . However, the coverage rate at the national level is only 6-10% of the targeted women, with 80-90% of all cervical cancer cases being diagnosed at an advanced stage 7,9,10 . This low coverage rate might be explained by the lack of mass communication and public awareness campaigns about the cervical cancer screening program 7 .…”

Epidemiological and Clinical Profile of Cervix Cancer at Bamako Radiotherapy Center

“…Diakité et al fourth leading cause of death among women at the worldwide level. In 2008, Cervix cancer represented 9% of new cancer cases and 8% of cancer deaths in women in the world [2] [3] [4].…”