Epidemiology and natural history of non-alcoholic fatty liver disease

Fazel, Yousef; Koenig, Aaron B.; Sayıner, Mehmet; Goodman, Zachary; Younossi, Zobair M.

doi:10.1016/j.metabol.2016.01.012

Cited by 362 publications

(311 citation statements)

References 104 publications

(32 reference statements)

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“…There are several risk factors associated with the progression from NAFLD to NASH, which include obesity, insulin resistance, hypertriglyceridemia, and low high-density lipoproteins (HDL) cholesterol (Fazel et al, 2016; Than and Newsome, 2015). To further investigate these pathways, we evaluated the relationship between certain genetic variants and specific metabolic measures.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in COL13A1, ADIPOQ and SAMM50 , in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population

Larrieta‐Carrasco

Flores

Macías-Kauffer

et al. 2018

Experimental and Molecular Pathology

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Non-alcoholic fatty liver disease (NAFLD) is the accumulation of extra fat in liver cells not caused by alcohol. Elevated transaminase levels are common indicators of liver disease, including NAFLD. Previously, we demonstrated that PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) are associated with elevated transaminase levels in overweight/obese Mexican adults. We investigated the association between 288 SNPs identified in genome-wide association studies and risk of elevated transaminase levels in an admixed Mexican-Mestizo sample of 178 cases of NAFLD and 454 healthy controls. The rs2896019, rs12483959, and rs3810622 SNPs in PNPLA3 and rs1227756 in COL13A1 were associated with elevated alanine aminotransferase (ALT, ≥40 IU/L). A polygenic risk score (PRS) based on six SNPs in the ADIPOQ, COL13A1, PNPLA3, and SAMM50 genes was also associated with elevated ALT. Individuals carrying 9–12 risk alleles had 65.8% and 48.5% higher ALT and aspartate aminotransferase (AST) levels, respectively, than those with 1–4 risk alleles. The PRS showed the greatest risk of elevated ALT levels, with a higher level of significance than the individual variants. Our findings suggest a significant association between variants in COL13A1, ADIPOQ, SAMM50, and PNPLA3, and risk of NAFLD/elevated transaminase levels in Mexican adults with an admixed ancestry. This is the first study to examine high-density single nucleotide screening for genetic variations in a Mexican-Mestizo population. The extent of the effect of these variations on the development and progression of NAFLD in Latino populations requires further analysis.

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Section: Discussionmentioning

confidence: 99%

Genetic variants in COL13A1, ADIPOQ and SAMM50 , in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population

Larrieta‐Carrasco

Flores

Macías-Kauffer

et al. 2018

Experimental and Molecular Pathology

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“…Ethical approval of this study was obtained by the research The study group included a consecutive series of 514 patients who underwent an angiography during the study period of Jun-Jan 2015. They were selected using the formula (1) …”

Section: Patientsmentioning

confidence: 99%

“…NAFLD is the most common abnormality seen in the pathology of the liver, which is defined as the presence of macrovascular steatosis (increasing of fat in liver without inflammation) and nonalcoholic steatohepatitis in the absence of significant alcohol consumption and negative virologic assessments (1). Nonalcoholic steatohepatitis may lead to fibrosis, cirrhosis, and liver failure.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between the Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) with the Severity of Coronary Artery Disease (CAD) in Patients Undergoing Coronary Artery Angiography: A Cross- Sectional Study

Tavakoli

Toba

Mollaei

et al. 2018

Iran Red Crescent Med J

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Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent liver diseases worldwide. There are several common risk factors between NAFLD and coronary artery disease (CAD). Objectives: This study aims to evaluate the relation between prevalence of NAFLD with severity of CAD in patients undergoing coronary artery angiography. Methods: This study was a cross-sectional descriptive-analysis research that included 514 patients who underwent angiography. The severity of CAD was assessed by the number of vessels involved (vessel score: vd). An ultrasound was performed for all patients and intensity of fatty liver involvement was graded from 0 (absence of steatosis) to 3 (severe steatosis). Results: Ultrasonographic examination proven NAFLD in 59.1% of patients with different grades. Patients with NAFLD had significantly higher body mass index (P < 0.001), waist circumference (P = 0.03), and age (P < 0.001). In addition, there were significant differences between ALT and AST within the normal group and NAFLD patients (P < 0.001). Moreover, coronary angiographic data indicated that the presence of NAFLD significantly correlated with the CAD severity score as so: 64% of people with 2vd and 60.5% of people with 3vd had fatty liver that was statistically significant (df = 4; P = 0.014). Conclusions: This study showed a high prevalence of NAFLD in patients with documented CAD. It is extremely important since knowing risk factors, designing screening programs, and early treatment of fatty liver could led to reducing the risk of cardiovascular diseases.

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“…In patients with NASH-related cirrhosis the cumulative incidence of HCC ranges from 2.4% to 12.8% [52], but, even if it is lower than that in HCV cirrhotic patients, the absolute burden of NASHrelated HCC is higher due to the higher number of patients with NAFLD in respect to HCV infected ones. It is very likely that this trend will continue to increase in the future, when the new therapies for hepatitis C and B and prevention programs will further reduce the size of viral infections of the liver [50,53].…”

Section: Natural History Of Nafldmentioning

confidence: 99%

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Alam¹

2017

GHOA

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Chronic hepatitis B (HBV) is one of the major diseases of mankind, estimated to cause about 686,000 deaths per year mostly from liver cancer and cirrhosis. And globally about 240 million people are chronically infected with hepatitis B. Nonalcoholic fatty liver disease (NAFLD) is an emerging commonest cause of chronic liver disease in the world. We have searched for CHB, NAFLD in PUBMED, Google scholar and local journals and related available articles were included in this review. Along with 184 countries of the world Bangladesh adopted hepatitis B vaccine in his EPI (expanded program on immunization) schedule for its prevention. And now about 95% of children are under cover of Hepatitis vaccine. Along with globally in last two decades' seroprevalence of HBsAg reduced about four times in Bangladesh. The prevalence of recorded nonalcoholic fatty liver disease (NAFLD) varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. The prevalence of NAFLD in Bangladesh is vary from 4%-18.4% and it is increasing day by day. About 40% of them are nonalcoholic steatohepatitis (NASH). They are in danger of progression to cirrhosis and hepatocellular carcinoma (15-19%) in next 5 to 10 years. Now it's becoming a silent killer for our nation. Gradual development of affluence, sedentary life style and increasing prevalence of diabetes contributed behind it. No effective treatment is available till now. Life style change by diet, exercise and weight reduction is the main stay of treatment. NAFLD involve multiple organs that leads to death due to cardiac, neurological and liver disease. Government and health department should take multidisciplinary action programs in awareness building and make a national guideline for fatty liver management.

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Epidemiology and natural history of non-alcoholic fatty liver disease

Cited by 362 publications

References 104 publications

Genetic variants in COL13A1, ADIPOQ and SAMM50 , in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population

Genetic variants in COL13A1, ADIPOQ and SAMM50 , in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population

The Relationship Between the Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) with the Severity of Coronary Artery Disease (CAD) in Patients Undergoing Coronary Artery Angiography: A Cross- Sectional Study

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

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