Epidemiology and molecular characterization of hepatitis B virus in Luanda, Angola

Valente, Fátima; Lago, Bárbara Vieira do; Castro, Cristiane; Almeida, Adílson José de; Gomes, Saint Clair; Soares, Caroline C.

doi:10.1590/s0074-02762010000800004

Cited by 28 publications

(33 citation statements)

References 43 publications

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“…Here, we confirmed these data and demonstrated that genotype E was the most prevalent, being detected in 65.9% genotyped samples collected from 6 of the 10 sampled provinces. This genetic diversity is consistent with the geography of the DRC, located at the crossroads of regions where HBV genotypes E, A, and D have been reported, namely, HBV/E in West and Central Africa, HBV/A in southern, East, and Central Africa, and HBV/D in North Africa (33). Neighboring countries such as Angola, the Central African Republic (CAR), Uganda, and Sudan have also reported the presence of these three genotypes (33–36).…”

Section: Discussionsupporting

confidence: 89%

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

et al. 2017

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The majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic of Congo (DRC) test negative for antibodies against yellow fever virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested for hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV) viruses, all of which can cause acute febrile jaundice, in patients included in the yellow fever surveillance program in the DRC. On a total of 498 serum samples collected from suspected cases of yellow fever from January 2003 to January 2012, enzyme-linked immunosorbent assay (ELISA) techniques were used to screen for antibodies against HAV (IgM) and HEV (IgM) and for antigens and antibodies against HBV (HBsAg and anti-hepatitis B core protein [HBc] IgM, respectively), HCV, and HDV. Viral loads and genotypes were determined for HBV and HVD. Viral hepatitis serological markers were diagnosed in 218 (43.7%) patients. The seroprevalences were 16.7% for HAV, 24.6% for HBV, 2.3% for HCV, and 10.4% for HEV, and 26.1% of HBV-positive patients were also infected with HDV. Median viral loads were 4.19 × 105 IU/ml for HBV (range, 769 to 9.82 × 109 IU/ml) and 1.4 × 106 IU/ml for HDV (range, 3.1 × 102 to 2.9 × 108 IU/ml). Genotypes A, E, and D of HBV and genotype 1 of HDV were detected. These high hepatitis prevalence rates highlight the necessity to include screening for hepatitis viruses in the yellow fever surveillance program in the DRC.

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Section: Discussionsupporting

confidence: 89%

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

et al. 2017

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“…23 Interestingly, HBV infection was significantly more frequent in men than women (12.5% versus 5.4%, respectively). This male preponderance has also been noticed in other studies conducted in EG as well as other African countries 8,24,25 and among subSaharan immigrants to Europe. 4,26 It contrasts with the higher proportion of women with HIV compared with men in Africa.…”

Section: Discussionsupporting

confidence: 82%

Hepatitis B, C, and D and HIV Infections among Immigrants from Equatorial Guinea Living in Spain

Rivas¹,

Herrero²,

Poveda³

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. A total of 1,220 subjects from Equatorial Guinea living in Spain (median age = 41 years; 453 male and 767 female) was examined for antibodies to human immunodeficiency virus (HIV) and Hepatitis B (HBV), C (HCV), and D (HDV) viruses. Extracted RNA and DNA from the positive samples were used to quantify viral load. The prevalence of HIV antibodies, HCV RNA, and HBV surface antigen (HBsAg) was 10.8% (N = 132), 11.6% (N = 141), and 7.9% (N = 96), respectively. The most prevalent HIV variant was CRF02_AG (38.5%; N = 40). HCV genotype 4 (60%; N = 36) and HBV genotype A3 (32%; N = 8) were the hepatitis variants most frequently found. Superinfection with HDV was seen in 20.9% (N = 24) of HBsAg carriers. A control group of 276 immigrants from other sub-Saharan countries showed similar rates of HIV and HBsAg, although no HCV cases were found. Immigrants constitute a major source of HIV and hepatitis viruses in Spain; therefore, it is important that control measures are intensified.

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“…and Gondar (1.0%) by Belay et al [6,8] and other countries; Angola (15.1%) by Fatima et al [7]. In contrast, the present study is very much lower when compared with the study conducted in Kumasi, Ghana (71.0%) by Jean-Pierre Allain et al .…”

Section: Discussioncontrasting

confidence: 76%

“…WHO estimated that the prevalence of HBV infection in Africa is on average more than 10%. However, a study conducted in Addis Ababa showed that the mean prevalence of HBsAg was 6.1% [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis B and C virus infections among patients with chronic hepatitis at Bereka Medical Center, Southeast Ethiopia: a retrospective study

Taye

Abdulkerim

Hussen³

2014

BMC Res Notes

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BackgroundViral hepatitis exists throughout the world and is a major global public health problem affecting millions of people. Hepatitis B (HBV) and hepatitis C (HCV) virus are the commonest causes of inflammation of the liver leading to chronic liver disease, cirrhosis, hepatocellular carcinoma and even fulminant hepatitis. The objective of this retrospective study was to determine the prevalence of infections with HBV and HCV among patients with chronic hepatitis who visited Bereka Medical Center, southeast Ethiopia.MethodsInstitution based retrospective study design was employed. HBV and HCV test records of all patients with chronic hepatitis who visited Bereka Medical Center from Nov. 2012 to Nov. 2013. A total of 578 (358 for HBV and 220 for HCV) patients with chronic hepatitis screened and the results of all patients were included. All sera were screened using commercially available rapid test kits. Test results were shown in percent and prevalence rates.ResultsThe overall prevalence of HBV and HCV among chronic hepatitis patients were 22.3% and 3.6% respectively. Prevalence of HBV and HCV among males from the total HBV and HCV screened was 52/358 (14.5%) and 6/220 (2.7%) respectively. 64/80 (80%) of HBV sero-positives were found in between 16 to 45 years of age. Of those 64 HBV sero-positive patients, 42/64 (65.6%) were found 16–30 age interval. Furthermore, of those HCV infected, 6/8 (75%) of them fall under 16–30 years of age. 6/8 (75%) of HCV infected patients were males.ConclusionThe present study has shown that HBV was highly prevalent among patients who visited the clinic. Males were more susceptible than female patients. 3.6% HCV prevalence was also high. Mass immunization of HBV is recommended to halt HBV infection.

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Epidemiology and molecular characterization of hepatitis B virus in Luanda, Angola

Cited by 28 publications

References 43 publications

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

High Prevalence and Diversity of Hepatitis Viruses in Suspected Cases of Yellow Fever in the Democratic Republic of Congo

Hepatitis B, C, and D and HIV Infections among Immigrants from Equatorial Guinea Living in Spain

Prevalence of hepatitis B and C virus infections among patients with chronic hepatitis at Bereka Medical Center, Southeast Ethiopia: a retrospective study

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