Epidemiology and Microbiological Profile of Common Healthcare Associated Infections among Patients in the Intensive Care Unit of a General Hospital in Kuwait: A Retrospective Observational Study

Abdo, Naglaa M.; Alali, Walid Q.; Mandegary, Ali

doi:10.2991/jegh.k.210524.001

Cited by 23 publications

(19 citation statements)

References 38 publications

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“…A. baumannii is able to cause both urinary tract infections (UTIs) and asymptomatic bacteriuria in both hospital and community settings ( 22 ). Several individual center studies report that A. baumannii is one of the most common uropathogens causing CAUTI in their facility ( 23 , 24 ). In addition, about one-fifth of A. baumannii clinical strains are isolated from the urine of patients suffering from UTIs ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Catheterization of mice triggers resurgent urinary tract infection seeded by a bladder reservoir of Acinetobacter baumannii

et al. 2023

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The antibiotic-resistant bacterium Acinetobacter baumannii is a leading cause of hospital-associated infections. Despite surveillance and infection control efforts, new A. baumannii strains are regularly isolated from health care facilities worldwide. In a mouse model of urinary tract infection, we found that mice infected with A. baumannii displayed high bacterial burdens in urine for several weeks. Two months after the resolution of A. baumannii infection, inserting a catheter into the bladder of mice with resolved infection led to the resurgence of a same-strain urinary tract infection in ~53% of the mice within 24 hours. We identified intracellular A. baumannii bacteria in the bladder epithelial cells of mice with resolved infection, which we propose could act as a host reservoir that was activated upon insertion of a catheter, leading to a resurgent secondary infection.

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Section: Introductionmentioning

confidence: 99%

Catheterization of mice triggers resurgent urinary tract infection seeded by a bladder reservoir of Acinetobacter baumannii

et al. 2023

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“…These patients usually suffer from severe underlying diseases and routine invasive procedures, which are commonly associated with the occurrence and mortality of CRPA infections in many studies ( 14 , 15 ). The incidence of infection in ICU patients is five–seven-fold higher than that in general inpatients, contributing to 20%−25% of all nosocomial infections in hospitals ( 16 ). It is important to timely identify risk factors for CRPA infection to prompt an effective intervention strategy to prevent the development of CRPA.…”

Section: Introductionmentioning

confidence: 99%

Carbapenem-resistant Pseudomonas aeruginosa infections in critically ill children: Prevalence, risk factors, and impact on outcome in a large tertiary pediatric hospital of China

Huang

Wei²,

Xu³

et al. 2023

Front. Public Health

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Background and aimsCarbapenem-resistant Pseudomonas aeruginosa (CRPA) is a major cause of healthcare-associated infections worldwide, but comprehensive study of clinical characteristics for CRPA infections among critically ill children remains limited in China. The objective of this study was to determine the epidemiology, risk factors, and clinical outcomes of CRPA infections among critically ill pediatric patients in a large tertiary pediatric hospital in China.MethodsA retrospective case-control study of patients with P. aeruginosa infections was conducted in the three intensive care units (ICUs) of Shanghai Children's Medical Center from January 2016 to December 2021. All patients with CRPA infection in the ICUs were enrolled as case patients. Patients with carbapenem-susceptible P. aeruginosa (CSPA) infection were randomly selected as control patients in a ratio of 1:1. Clinical characteristics of those inpatients were reviewed through the hospital information system. Univariate and multivariate analyses were performed to evaluate risk factors associated with the development of CRPA infections and mortality of P. aeruginosa infections.ResultsA total of 528 cases of P. aeruginosa infection in the ICUs were enrolled in the 6-year study. The prevalence of CRPA and MDRPA (multidrug-resistance P. aeruginosa) was 18.4 and 25.6%, respectively. Significant risk factors related to CRPA infection were the length of hospitalization >28 days (OR = 3.241, 95% CI 1.622–6.473, p = 0.001), receiving invasive operations (OR = 2.393, 95% CI 1.196–4.788, p = 0.014) and a blood transfusion (OR = 7.003, 95% CI 2.416–20.297, p < 0.001) within 30 days before infection. Conversely, birth weight ≥2,500 g (OR = 0.278, 95% CI 0.122–0.635, p = 0.001) and breast nursing (OR = 0.362, 95% CI 0.168–0.777, p = 0.009) were significant protective factors against CRPA infections. The in-hospital mortality rate was 14.2%, and no difference in mortality was observed between patients with CRPA and CSPA infections. Platelet < 100 × 109/L (OR = 5.729, 95% CI 1.048–31.308, p = 0.044) and serum urea <3.2 mmol/L (OR = 5.173, 95% CI 1.215–22.023, p = 0.026) were independent predictors for the mortality due to P. aeruginosa infection.ConclusionsOur findings provide insights into CRPA infections among critically ill children in China. They provide guidance in identifying patients that may be at high risk for a resistant infection and emphasize the importance of antimicrobial stewardship and infection control in hospitals.

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“…Another study from Ethiopia showed that Gram-negative bacteria were isolated from 8.3% of HCWs’ mobile phones and 79.4% of the isolates were multidrug resistant [ 31 ]. Antibiotic-resistant bacteria are the most serious health risk for hospitalized patients [ 32 ]. Besides, Enterococcus faecium and E. coli were isolated from mobile phones in this study, which suggested poor hygiene conditions of mobile phones and hands because these bacteria are part of the intestinal flora.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Colonization on Healthcare Workers’ Mobile Phones and Hands in Municipal Hospitals of Chongqing, China: Cross-contamination and Associated Factors

Yao¹,

Yang²,

Zhu³

et al. 2022

J Epidemiol Glob Health

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Background Mobile phones are widely used in clinical settings and could be colonized by potential pathogenic bacteria which may lead to hospital-acquired infections (HAIs) transmission. This study aimed to determine the prevalence of bacterial contamination of healthcare workers’ (HCWs) mobile phones, identify bacterial isolates, and assess the factors associated with mobile phone contamination. Methods Self-administered questionnaire was used to collect the information on the demographic characteristics and the use of mobile phones. A total of 111 HCWs’ hands and their mobile phones were swabbed, then bacterial culture, isolation, and identification were performed. Univariate and multivariable logistic regression were applied to identify factors associated with mobile phone bacterial contamination. Results Totally 106 (95.5%) of the 111 mobile phones investigated were contaminated with bacteria. Staphylococcus epidermidis (13/111), Acinetobacter baumannii (4/111) and Staphylococcus aureus (3/111) were the predominant bacterial isolates from HCWs’ mobile phones. Univariate analyses showed that age, gender, profession and the frequency of mobile phone utilization were significantly associated with the number of bacterial colonization. Frequency of phone utilization (OR 8.366; 95% CI 1.496–46.797) was found to be the most significant factors associated with the qualified rate of mobile phones bacterial load. In addition, phone cover using was associated with the increased risk of mobile phone bacterial contamination. Conclusion There was cross-contamination between hands and phones. It is necessary to develop guidelines for mobile phone cleaning. Special attention needs to be paid to the disinfection of mobile phone covers to reduce contamination and transmission of pathogens.

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Epidemiology and Microbiological Profile of Common Healthcare Associated Infections among Patients in the Intensive Care Unit of a General Hospital in Kuwait: A Retrospective Observational Study

Cited by 23 publications

References 38 publications

Catheterization of mice triggers resurgent urinary tract infection seeded by a bladder reservoir of Acinetobacter baumannii

Catheterization of mice triggers resurgent urinary tract infection seeded by a bladder reservoir of Acinetobacter baumannii

Carbapenem-resistant Pseudomonas aeruginosa infections in critically ill children: Prevalence, risk factors, and impact on outcome in a large tertiary pediatric hospital of China

Bacterial Colonization on Healthcare Workers’ Mobile Phones and Hands in Municipal Hospitals of Chongqing, China: Cross-contamination and Associated Factors

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