Epidemiology and maternal prognosis of hypertension disorders of pregnancy in French Guiana

Mhiri, Raoudha; Mvogo, Alexandra; Kamga, A. C. T.; Yassinguezo, Samson; Fagla, Herliche; Dotou, Dominique; Kallel, Hatem

doi:10.1016/j.preghy.2020.03.010

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…French Guiana-a French territory between Brazil and Suriname -has one of the highest birth rates in Latin America and in France [https://www.insee.fr/fr/statistiques/3309060]. There is a very high prevalence of preterm delivery and preeclampsia (1)(2)(3). In addition, the prevalence of obesity and diabetes in French Guiana are very high (respectively 17% (4) and 10% (5), notably among women).…”

Section: Introductionmentioning

confidence: 99%

Does Universal Screening for Gestational Diabetes Mellitus Improve Neonatal Outcomes in a Socially Vulnerable Population: A Prospective Study in French Guiana

et al. 2021

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Aims/IntroductionFrench Guiana has a high prevalence of metabolic diseases, which are risk factors for gestational diabetes mellitus. Despite routine screening for gestational diabetes, treatment is still challenging because of health inequalities and different cultural representations of disease and pregnancy. This study was conducted to assess the role of early and universal GDM screening on obstetrical and neonatal complications in a socially deprived population.Materials and MethodsA prospective study was conducted, in the level III maternity in French Guiana. Of 2136 deliveries, 223 had gestational diabetes mellitus, 110 of whom were followed-up for 6 month to detail their social and laboratory parameters.ResultsThe prevalence of gestational diabetes in French Guiana (Cayenne Hospital) was estimated at 10.3%. The study population was very precarious with 70% of patients on welfare (universal health coverage or state medical assistance). The following obstetrical complications were observed: cesarean delivery (32%), history of miscarriage (26%) and preeclampsia (7.4%). Nevertheless, neonatal complications were rarely present and included hypoglycemia (2.8%) and macrosomia (2.8%).ConclusionIn French Guiana, gestational diabetes mellitus is very common. However, in a context of widespread poverty and diverse cultural representations, universal screening and monitoring limited the risk of macrosomia.

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Section: Introductionmentioning

confidence: 99%

Does Universal Screening for Gestational Diabetes Mellitus Improve Neonatal Outcomes in a Socially Vulnerable Population: A Prospective Study in French Guiana

et al. 2021

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“…Another aspect that will contribute to reducing SVN is ensuring that women have access to health insurance as it can explain some risk factors such as a late first pregnancy visit that is detrimental to a good pregnancy follow-up that can contribute to mitigate the multiple risk factors associated with having SVN with adequate prevention. For instance, pre-eclampsia, is known to be particularly frequent in French Guiana, especially among the most precarious [21], and early interventions have been shown to be essential to limit complications effects associated with this condition [59].…”

Section: Discussionmentioning

confidence: 99%

“…Infant mortality is 2.6 times higher than in mainland France [20]. Given the frequency of poor pregnancy follow-up, food insecurity and nutritional deficiencies, obstetrical outcomes are still often poor [21]. Although preterm deliveries have been studied in French Guiana, few studies have addressed low birth weight so far.…”

Section: Introductionmentioning

confidence: 99%

Small for Gestational Age Newborns in French Guiana: The Importance of Health Insurance for Prevention

Osei,

Vignier,

Nacher

et al. 2024

Int J Public Health

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Objectives: Small for gestational age (SGA) newborns have a higher risk of poor outcomes. French Guiana (FG) is a territory in South America with poor living conditions. The objectives of this study were to describe risk factors associated with SGA newborns in FG.Methods: We used the birth cohort that compiles data from all pregnancies that ended in FG from 2013 to 2021. We analysed data of newborns born after 22 weeks of gestation and/or weighing more than 500 g and their mothers.Results: 67,962 newborns were included. SGA newborns represented 11.7% of all newborns. Lack of health insurance was associated with SGA newborns (p < 0.001) whereas no difference was found between different types of health insurance and the proportion of SGA newborns (p = 0.86). Mothers aged less than 20 years (aOR = 1.65 [1.55–1.77]), from Haiti (aOR = 1.24 [1.11–1.39]) or Guyana (aOR = 1.30 [1.01–1.68]) and lack of health insurance (aOR = 1.24 [1.10–1.40]) were associated with SGA newborns.Conclusion: Immigration and precariousness appear to be determinants of SGA newborns in FG. Other studies are needed to refine these results.

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“…Most patients exhibit symptoms of systemic arteriolar spasm, which can cause insufficiency of blood supply in the microcirculation of organs throughout the body. In severe cases, GH can even lead to failure and necrosis of all organs ( 29 ). At present, effective control of blood pressure is the key to clinical treatment of GH, and spasmolysis and pressure reduction are the basic principles of treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of magnesium sulfate combined with labetalol on inflammatory stress and pregnancy outcome of patients with gestational hypertension

Gu,

Zhang

et al. 2024

Exp Ther Med

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Gestational hypertension (GH) is a common disorder during pregnancy that can cause adverse pregnancy outcomes. In the present study, magnesium sulfate (MgSO 4 ) combined with labetalol was used for clinical treatment. Randomized controlled trial was conducted in 100 patients with GH, documented in the Department of Obstetrics and Gynecology (Taicang TCM Hospital) grouped into the experimental (Expt) and control (Ctrl) groups (n=50 cases/group). The Ctrl group was treated with MgSO 4 , whereas the Expt group was treated with MgSO 4 + labetalol. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the Expt group were not significantly different from those in the Ctrl group (P>0.05). By contrast, the SBP and DBP were significantly lower after treatment than those before treatment in both groups (P<0.05). Whole blood viscosity, plasma viscosity and hematocrit were significantly lower in the Expt group compared with those in the Ctrl group after treatment (P<0.05). High mobility group box-1 protein, homocysteine and serum cystatin C levels in the Expt group were also markedly lower than those in the Ctrl group after treatment (P<0.05). In the Expt group, the rate of spontaneous vaginal delivery was much higher, whereas the rates of cesarean section and postpartum hemorrhage were markedly lower than those in the Ctrl group (P<0.05). The occurrence of fetal intrauterine distress, placental abruption, neonatal asphyxia, premature birth and neonatal death were also significantly lower in the Expt group than those in the Ctrl group (P<0.05). In conclusion, MgSO 4 + labetalol could improve inflammatory stress and the hemodynamics of patients with GH, and may have a marked antihypertensive effect. Thus, it may improve pregnancy outcome and reduce perinatal complications.

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Epidemiology and maternal prognosis of hypertension disorders of pregnancy in French Guiana

Cited by 3 publications

References 20 publications

Does Universal Screening for Gestational Diabetes Mellitus Improve Neonatal Outcomes in a Socially Vulnerable Population: A Prospective Study in French Guiana

Does Universal Screening for Gestational Diabetes Mellitus Improve Neonatal Outcomes in a Socially Vulnerable Population: A Prospective Study in French Guiana

Small for Gestational Age Newborns in French Guiana: The Importance of Health Insurance for Prevention

Effects of magnesium sulfate combined with labetalol on inflammatory stress and pregnancy outcome of patients with gestational hypertension

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