Epidemiology and Long‐term Survival in Acromegaly: <i>A Study of 166 Cases Diagnosed between 1955 and 1984</i>

Bengtsson, Bengt‐Åke; Edén, Staffan; Ernest, Ingrid; Odén, Anders; Sjögren, Björn

doi:10.1111/j.0954-6820.1988.tb15881.x

Cited by 477 publications

(106 citation statements)

References 18 publications

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“…was calculated in the Newcastle region (UK). A similar prevalence, ranging from 60 to 69 c.p.m., was reported a few years later in the studies carried out in Spain, Sweden, and Northern Ireland (11)(12)(13). During the last The demography of the condition in the four zones characterized by a different degree of exposition to environmental toxins showed a prevalence of 210 c.p.m.…”

Section: Discussionmentioning

confidence: 77%

Increased prevalence of acromegaly in a highly polluted area

Cannavò

Ferraú

Ragonese

et al. 2010

European Journal of Endocrinology

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Objective: Despite the contribution of national registries and population-based reports, data concerning the epidemiology of acromegaly is scanty. In addition, the role of the environmental context has not been investigated. Design: Epidemiology of acromegaly was studied in the province of Messina (Sicily, Italy), focusing on the influence of environmental factors. Methods: Four zones, characterized by different degrees of exposition to environmental toxins due to industrial pollution, were identified in the province: area A (76 338 inhabitants), area B (287 328 inhabitants), area C (243 381 inhabitants), and area D (47 554 inhabitants) at low, middle-low, middle, and high industrial density respectively. We identified all acromegalics who were born and resided in the province of Messina, among patients either referred to our endocrine unit or referred elsewhere but recorded in the archives of the provincial healthcare agency.

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Section: Discussionmentioning

confidence: 77%

Increased prevalence of acromegaly in a highly polluted area

Cannavò

Ferraú

Ragonese

et al. 2010

European Journal of Endocrinology

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“…Cardiovascular and glucose metabolism alterations are known to be more frequent in patients with acromegaly and dependent on disease control (6). This interrelation could be a possible explanation for the observation that comorbidities have lost their significant influence in multivariate analysis where biochemical status has preserved its dominant role (2,33,35,38). In agreement, in our study, hypertension, diabetes mellitus, and dyslipidemia were not independent predictors of mortality in the multivariate analysis.…”

Section: Clinical Studymentioning

confidence: 99%

“…Acromegaly is a rare disease with an estimated annual incidence of 3-4 cases/million population and a prevalence of cases/million population (1,2). More recent data (3,4) have reported a higher prevalence of one case out of 8000-11 000 individuals.…”

Section: Introductionmentioning

confidence: 99%

Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy)

Colao

Vandeva

Pivonello

et al. 2014

European Journal of Endocrinology

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Background: Mortality in acromegaly strictly depends on optimal control of GH and IGF1 levels. Modern medical therapy with somatostatin analogs (SSAs) and GH receptor antagonists (GHRAs) is not available in many countries due to funding restrictions. This retrospective, comparative, cohort study investigated the impact of different treatment modalities on disease control (GH and IGF1) and mortality in acromegaly patients. Methods: Two cohorts of patients with acromegaly from Bulgaria (nZ407) and Campania, Italy (nZ220), were compared, and mortality rates were evaluated during a 10-year period (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008). Results: The major difference in treatment approach between cohorts was the higher utilization of SSAs and GHRAs in Italy, leading to a decreased requirement for radiotherapy. Significantly more Italian than Bulgarian patients had achieved disease control (50.1 vs 39.1%, PZ0.005) at the last follow-up. Compared with the general population, the Bulgarian cohort had a decreased life expectancy with a standardized mortality ratio (SMR) of 2.0 (95% CI 1.54-2.47) that was restored to normal in patients with disease control -SMR 1.25 (95% CI 0.68-1.81). Irradiated patients had a higher cerebrovascular mortality -SMR 7.15 (95% CI 2.92-11.37). Internal analysis revealed an independent role of age at diagnosis and last GH value on all-cause mortality and radiotherapy on cerebrovascular mortality. Normal survival rates were observed in the Italian cohort: SMR 0.66 (95% CI 0.27-1.36). Conclusions: Suboptimal biochemical control was associated with a higher mortality in the Bulgarian cohort. Modern treatment options that induce a strict biochemical control and reduce the necessity of radiotherapy might influence the life expectancy. Other factors, possibly management of comorbidities, could contribute to survival rates.

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“…It is well established that acromegaly is associated with an increased prevalence of colorectal, breast, prostate and thyroid cancers, as determined in several epidemiological studies (1)(2)(3). However, it is currently unclear whether patients with acromegaly are at an increased risk of developing adrenal tumors.…”

Section: Introductionmentioning

confidence: 99%

Poorly-controlled Acromegaly Accompanied by Subclinical Adrenal Cushing's Syndrome after Surgery for Multiple Endocrine Tumors

et al. 2015

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A 48-year-old woman diagnosed with acromegaly 21 years earlier presented at our hospital with a left adrenal tumor. Her medical history included breast cancer, thyroid cancer and an incompletely resected growth hormone (GH)-producing pituitary adenoma. Endocrinological and radiological examinations revealed subclinical adrenal Cushing's syndrome. She subsequently underwent left adrenalectomy, followed by glucocorticoid replacement therapy. Her GH and insulin-like growth factor-1 levels were insufficiently controlled, and pegvisomant was administered in addition to octreotide acetate. Following adrenalectomy, a giant hepatic hemangioma and papillary thyroid carcinoma in the residual right lobe developed, indicating the high risk of tumor development in patients with acromegaly.

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Epidemiology and Long‐term Survival in Acromegaly: A Study of 166 Cases Diagnosed between 1955 and 1984

Cited by 477 publications

References 18 publications

Increased prevalence of acromegaly in a highly polluted area

Increased prevalence of acromegaly in a highly polluted area

Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy)

Poorly-controlled Acromegaly Accompanied by Subclinical Adrenal Cushing's Syndrome after Surgery for Multiple Endocrine Tumors

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