Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)

Abstract

Background Carbapenem resistant (CR) Klebsiella pneumoniae (Kp) and Acinetobacter baumannii (Ab) are emerging multidrug resistant bacteria with very limited treatment options in case of infection. Both are well-known causes of nosocomial infections and outbreaks in healthcare facilities. Methods A retrospective study was conducted to investigate the epidemiology of inpatients with CR Kp and CR Ab in a 1500-bed German university hospital from 2015 to 2019. We present our infection control concept including a weekly microbiologic screening for patients who shared the ward with a CR Kp or CR Ab index patient. Results Within 5 years, 141 CR Kp and 60 CR Ab cases were hospitalized corresponding to 118 unique patients (74 patients with CR Kp, 39 patients with CR Ab and 5 patients with both CR Ab and CR Kp). The mean incidence was 0.045 (CR Kp) and 0.019 (CR Ab) per 100 inpatient cases, respectively. Nosocomial acquisition occurred in 53 cases (37.6%) of the CR Kp group and in 12 cases (20.0%) of the CR Ab group. Clinical infection occurred in 24 cases (17.0%) of the CR Kp group and in 21 cases (35.0%) of the CR Ab group. 14 cases (9.9%) of the CR Kp group and 29 cases (48.3%) of the CR Ab group had a history of a hospital stay abroad within 12 months prior to admission to our hospital. The weekly microbiologic screening revealed 4 CR Kp cases caused by nosocomial transmission that would have been missed without repetitive screening. Conclusions CR Kp and CR Ab cases occurred infrequently. A history of a hospital stay abroad, particularly in the CR Ab group, warrants pre-emptive infection control measures. The weekly microbiologic screening needs further evaluation in terms of its efficiency.

Epidemiology and infection control of vancomycin-resistant enterococci at a German university hospital: A three-year retrospective cohort study

“…The burden of VRE in our study was clearly higher than the burden of carbapenem-resistant Acinetobacter baumannii or carbapenem-resistant Klebsiella pneumoniae in our hospital (both <0.1%; time period 2015–2019) [ 26 ].…”

The Phylogency (Evolutionary Relationship) and Antibiogram of Acinetobacter baunmanni Isolated from Tertiary Health Institutions in Rivers State Nigeria

“…Also, Acinetobacter baumanii, and Klebsiella pneumonia possess the potential to cause respiratory (lung) infection such as pneumonia. Besides, both organisms are well known to cause nosocomial infection [1]. The emergence of Acinetobacter baumannii and Klebsiella pneumoniae strains in the hospital environment has been associated with the presence of multiple genetic elements, virulence factors and the ability to form biofilms (Paola et al, 2016).…”

Karbapenem dirençli Pseudomonas ve Acinetobacter türlerinde MBL üretiminin saptanması ve risk faktörlerinin değerlendirilmesi.

“…Multi-drug resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are the most commonly isolated bacteria among the agents of healtcare infections. These agents leading to severe infections and outbreaks especially in the intensive care units have become increasingly resistant to many antibiotics as well as carbapenem, with a significant threat to public health across the world [1][2][3][4].…”