Epidemiology and genetics of intracranial aneurysms

Caranci, Ferdinando; Briganti, Francesco; Cirillo, Luigi; Leonardi, Marco; Muto, Mario

doi:10.1016/j.ejrad.2012.12.026

Cited by 145 publications

(112 citation statements)

References 62 publications

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“…Thus, it is important to identify the characteristics of individuals who are at high risk of IA and focus on regularly screening for IA. Previous studies indicate that genetics contribute to the development of IA (27)(28)(29). Furthermore, it is of great value to investigate the genetic architecture and establish the underlying molecular mechanism of IA.…”

Section: Discussionmentioning

confidence: 99%

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis

et al. 2017

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Abstract.Various studies have evaluated the association between polymorphisms of angiotensin-converting enzyme (ACE) and intracranial aneurysm (IA) risk; however, the results remain inconsistent. The PubMed, Embase, and Wanfang Data databases were systematically searched until January 6th 2016. Case-control studies investigating the association between the ACE polymorphism and IA risk were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with the fixed or random-effects model assuming allele, homozygote comparison of codominant, heterozygote comparison of codominant, dominant, and recessive models. Seven studies including 1,074 cases and 1,500 controls were included in the current meta-analysis. The results of the analysis indicated that the ACE polymorphism significantly increased IA risk in the allele, homozygote comparison of codominant and dominant models. According to the further stratified analysis by ethnicity, source of control and sample sizes, a significant association was identified between the ACE variant and IA risk in Asian individuals, hospital-based, or large (>300) subgroups in all of the genetic models, not including the recessive model. Furthermore, no significantly increased risk was indicated in Caucasian individuals, population-based, or small (<300) subgroups in the heterozygote comparison of codominant, dominant and recessive models. The available evidence indicates that the ACE polymorphism is associated with an increased risk of IA, particularly in Asian individuals. However, other factors may impact this association. Further large, well-designed multicenter studies are required to validate the findings from the present study.

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Section: Discussionmentioning

confidence: 99%

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis

et al. 2017

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“…Smatra se da nastaju kao posljedica kongenitalnog zastoja u razvoju dijela zida krvnog suda ili na mjestima primarno nerazvijenih arterijskih pupoljaka [1,2]. U prilog kongenitalnoj teoriji govori i udruženost aneurizmi na krvnim sudovima mozga sa drugim oboljenjima, policističnim oboljenjima bubrega, koarktacijom aorte, Marphan-ovim sindromom, oboljenjima vezivnog tkiva.…”

Section: Uvodunclassified

Gigantska aneurizma unutrašnje karotidne arterije, mogućnosti liječenja u zavisnosti od operativnog rizika

Ivanišević¹,

Saratlić

Maric

et al. 2017

Biomedicinska istraž.

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Kratak sadržajUvod. Intrakranijalne aneurizme se definišu kao gigantske ako su veće od 25 mm i rijetke su intrakranijalne lezije. Obično se manifestuju znacima subarahnoidalnog krvarenja, ili kompresivnim "mass" efektom kao tumor, epileptičnim napadom ili znacima tromboembolije. Nakon dijagnostike, kompujuterizovane tomografije i magnetne rezonance (MRI) mozga i angiografske dijagnostike, postavljaju se indikacije za mikrovaskularni kliping ili endovaskularni tretman. Opisan je slučaj 78 godina stare bolesnice sa gigantskom aneurizmom unutrašnje karotidne arterije (ACI).Prikaz bolesnika. Žena stara 78 godina, prvi put u životu je dobila epileptični napad. Pacijentkinja je srčani bolesnik sa istorijom masivnog dijafragmalnog infarkta koji je imala prije tri mjeseca. Nakon urađenog MRI mozga i MRI angiografije dokazano je postojanje gigantske aneurizme ACI desno. S obzirom na kardijalni status i visok rizik za bilo koju vrstu intervencije, odlučili smo se na konzervativni tretman uz praćenja, kontrolu krvnog pritiska, i redovnu internističku terapiju, odgovarajući režim ishrane i antiepileptičnu terapiju, te kontrolnu MRI angiografiju za 6 mjeseci.Zaključak. Uprkos prikazanim velikim serijama i analizama nije donesen konsenzus o riziku i ishodu poslije hirurškog klipinga aneurizme ili endovaskularne procedure koji se statistički ne razlikuje značajno. Samo u posebnim slučajevima, kada je rizik za bilo koji tretman gigantske nerupturirane aneurizme visok (godine starosti, kardijalni status), a uz činjenicu da je njihova sklonost rupturi mala, treba se odlučiti na praćenje uz prevenciju drugih negativnih faktora.Ključne riječi: gigantske aneurizme, krvni sudovi mozga, hiruško liječenje, endovaskularne procedure

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“…In majority of analyzes there were no differences found between sexes in terms of IAs frequency in ADPKD [14,15,17,29] . Interestingly in the general population IAs are more frequently diagnosed in woman (woman to man proportion is 3: 1) [3,25] and are more likely to occur in Afro-Americans [26] . In the general population most common localization for IAs is the internal carotid artery [11,13,18] ; in the ADPKD most aneurysms can be found in the anterior circulation, with the highest prevalence in the middle cerebral artery [17,19] .…”

Section: S C R E E N I N G F O R I N T R a C R A N I A L Aneurysmsmentioning

confidence: 99%

Intracranial Manifestations of Autosomal Dominant Polycystic Kidney Disease

Kulesza

Gradzik

Niemczyk

2016

International Journal of Neurology Research

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Autosomal dominant polycystic kidney disease (ADPKD) belongs to the most common genetic disorders, and affects approximately 1 in 1,000 people in the general population. ADPKD is a systemic disease, with multiple extrarenal manifestations, like arterial hypertension, aneurysms, and cysts in solid organs, including liver, pancreas, and spleen. Among intracranial manifestations of ADPKD, the most important are intracranial aneurysms. ADPKD is a well-known risk factor for them. Additionally, arachnoid cysts may be found in some ADPKD patients. Rarely, pineal cysts and choroid plexus cysts are observed in this population. The aim of our paper is to present intracranial manifestations that may be observed in ADPKD.

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Epidemiology and genetics of intracranial aneurysms

Cited by 145 publications

References 62 publications

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis

Gigantska aneurizma unutrašnje karotidne arterije, mogućnosti liječenja u zavisnosti od operativnog rizika

Intracranial Manifestations of Autosomal Dominant Polycystic Kidney Disease

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