Epidemiology and genetics of dilated cardiomyopathy in the Indian context

Ushasree, B.; Shivani, V.; Ananthapur, Venkateshwari; Jain, R. K.; Calambur, Narsimhan; Nallari, Pratibha

doi:10.4103/0019-5359.55114

Cited by 8 publications

(2 citation statements)

References 32 publications

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“…[9–11] Myocardial dysfunction in patients with hypocalcemia is well described in the literature. [5–812] Hypocalcemia causes decreased myocardial contractility, leading to CHF, hypotension, and angina.…”

Section: Discussionmentioning

confidence: 99%

Hypocalcemic cardiomyopathy presenting as cardiogenic shock

et al. 2011

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Hypocalcemia is a less known but treatable cause for dilated cardiomyopathy, leading to severe heart failure in children. Cardiogenic shock related to hypocalcemic cardiomyopathy is a rare event. We describe 5 infants presenting with cardiogenic shock over 3 years, who were found to have severe hypocalcemia as a sole cause of myocardial dysfunction. The patients responded to calcium and vitamin D supplementation promptly and left ventricular systolic function normalized within months of treatment. In any case of cardiogenic shock, hypocalcemia should be included in the differential diagnosis and must be investigated.

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Section: Discussionmentioning

confidence: 99%

Hypocalcemic cardiomyopathy presenting as cardiogenic shock

et al. 2011

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“…This region encompasses several genes among which HSPB7 was previously suggested to be implicated in DCM whereas rs2234962 was a non-synonymous SNP (c.T757C, p. C151R) which is located within the sequence of BAG3 on chromosome 10q26 [26]. To date, there are very few reports regarding the genetic background of LMNA in Indian population [27], [28]. In the present study, we showed for the first time the association of variations in LMNA gene with IDCM in Indian population.…”

Section: Discussionmentioning

confidence: 99%

Novel linkage of LMNA Single Nucleotide Polymorphism with Dilated Cardiomyopathy in an Indian case study

Banerjee

Ghoshal

Sengupta

2015

IJC Heart & Vasculature

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BackgroundDilated Cardiomyopathy (DCM) is one of the most commonly encountered heart diseases reported globally. It is characterized by enlarged ventricles with impaired systolic and diastolic functions. Mutations in LMNA gene are one of the causative factors to precipitate the disease. However, association of SNPs of LMNA with DCM in particular has not been well documented.MethodHere we present a limited and restricted case study of patients from south eastern part of India afflicted with idiopathic DCM and conduction defects. By using next generation sequencing we have sequenced the exons of LMNA gene from genomic DNA isolated from patients.ResultWe have identified the linkage of 8 different LMNA SNPs with idiopathic DCM viz. rs121117552, rs538089, rs505058, rs4641, rs646840, rs534807, rs80356803 and rs7339. These SNPs are scattered throughout the gene with prevalence for the region encoding the central rod domain of lamin A/C.ConclusionMost of these SNPs in LMNA were previously reported to be involved in various disorders other than DCM. We conclude that, variation in LMNA is one of the major underlying genetic causes for the pathogenesis of DCM, as observed in few Indian populations.

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