Epidemiology and endocrinology of benign breast disease

Wang, D. Y.; Fentiman, Ian S.

doi:10.1007/bf01806008

Cited by 88 publications

(54 citation statements)

References 142 publications

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“…corresponds to P>0.05. (Anderson et al, 1977;Dupont & Page, 1985;Wang & Fentiman, 1985;Kelsey & Berkowitz, 1988;Dupont et al, 1989). The magnitude of the observed effects seems to be in agreement with data reported by these authors.…”

Section: Discussionsupporting

confidence: 85%

Cyclical mastalgia as a marker of breast cancer susceptibility: results of a case-control study among French women

Plu‐Bureau

Jc²,

Sitruk-Ware³

et al. 1992

Br J Cancer

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Section: Discussionsupporting

confidence: 85%

Cyclical mastalgia as a marker of breast cancer susceptibility: results of a case-control study among French women

Plu‐Bureau

Jc²,

Sitruk-Ware³

et al. 1992

Br J Cancer

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“…The cyclic nature of the breast pain, the presence of breast symptoms such as swelling, tenderness, and nodularity, and the cessation of these symptoms in the postmenopausal period are probably due to the effects of the estrogen hormone [20,21]. Considering lactation, the percentage of women with a history of breast feeding 3 or more infants was increased in the mastalgia group (p < 0.01).…”

Section: Discussionmentioning

confidence: 94%

Factors Effecting Mastalgia

et al. 2016

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Background: Breast pain is one of the leading complaints that ends up with referral to breast surgery clinics. The purpose of the present study was to investigate the factors that cause mastalgia, and its relation with benign or malignant breast disease. Methods: The study was performed in 700 patients. Data obtained from surveys, and imaging findings were prospectively recorded, and analyzed. Results: The mean age was 45.20 ± 10.78 years. The mastalgia group included 500 cases; the asymptomatic group comprised 200 individuals. Stressful lifestyle, caffeine consumption, and smoking were associated with mastalgia (p < 0.05). Rates of women who had breast fed 3 times or more were higher in the mastalgia group (p < 0.05). Increased breast density, and breast imaging-reporting and data system (BI-RADS) 2 mammography findings were related with mastalgia (p < 0.05). Cysts and fibroadenomas were more common in the mastalgia group (p < 0.05). The incidence of a past history of malignant breast disease was significantly higher in the mastalgia group (p < 0.05). Conclusions: Stress, caffeine, smoking, lactation frequency, and benign disorders were factors detected to be related with mastalgia. Although a significant relation between mastalgia and malignant breast disease was detected in our study, more controlled studies are still required to investigate this issue further.

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“…Although the etiology of cyclical mastalgia has not been established, some evidence has implicated elevated estrogen levels, low progesterone levels, or an abnormal estrogen/ progesterone ratio (6). Physiologically, a direct link between breast susceptibility to the estrogen microenvironment and the occurrence of cyclical mastalgia is suggested by several observations: (a) its bilaterality and periodicity according to the different phases of the menstrual cycle; (b) its occurrence or exacerbation after exposure to estrogens contained in both oral contraceptives and hormonal replacement therapies; (c) its disappearance after surgical or chemical ovarian suppression or antiestrogen therapy.…”

Section: Introductionmentioning

confidence: 99%

Cyclical Mastalgia and Breast Cancer Risk: Results of A French Cohort Study

Plu‐Bureau

Lê

Sitruk-Ware

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Cyclical mastalgia is a common complaint, with a potentially important relationship to breast cancer risk. In the last decade, case-control studies have reported that cyclical mastalgia could be considered as an independent risk factor for breast cancer. The subjectivity of a retrospectively collected symptom questioned the validity of this finding. We have examined the association between cyclical mastalgia and breast cancer risk in the French cohort study of women with benign breast disease diagnosed in two breast clinics between 1976 and 1979 and followed-up until 1997. The present study was restricted to the women free of any hormonal treatment (n = 247). The mean follow-up was 16 F 5 years, and a total of 22 breast cancers occurred during the follow-up. Using a Cox model with duration of cyclical mastalgia as a time-varying variable, the adjusted relative risk of breast cancer increased with the duration of cyclical mastalgia (P = 0.006). The corresponding relative risk for 37 months of cyclical mastalgia was 5.31 (95% confidence interval, 1.92-14.72). We show here that the conclusion still holds when the symptom cyclical mastalgia was collected prospectively in a cohort study, bringing additional evidence that cyclical mastalgia may represent an independent and useful clinical marker of increased breast cancer risk. It might be a confounding factor when assessing the effects of hormonal treatments on breast cancer risk such as hormonal replacement therapy or oral contraceptives. (Cancer Epidemiol Biomarkers Prev 2006; 15(6):1229 -31)

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Epidemiology and endocrinology of benign breast disease

Cited by 88 publications

References 142 publications

Cyclical mastalgia as a marker of breast cancer susceptibility: results of a case-control study among French women

Cyclical mastalgia as a marker of breast cancer susceptibility: results of a case-control study among French women

Factors Effecting Mastalgia

Cyclical Mastalgia and Breast Cancer Risk: Results of A French Cohort Study

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