Epidemiology and determinants of reemerging bacterial sexually transmitted infections (STIs) and emerging STIs in Europe

Mitjà, Oriol; Padovese, Valeska; Folch, Cinta; Rossoni, Isotta; Marks, Michael; Rodríguez i Arias, Miquel Angel; Telenti, Amalio; Ciuffi, Angela; Blondeel, Karel; Mårdh, Otilia; Casabona, Jordi

doi:10.1016/j.lanepe.2023.100742

Cited by 17 publications

(12 citation statements)

References 104 publications

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“…In response to the recently reported substantial increase in bacterial STIs over the past decade in Europe with particular focus on MSM [ 32 ], the study was conducted to assess the potential of doxycycline-based STI prevention in case of optimized adherence compared with alternative preventive strategies like condom-based prevention and testing-as-prevention. Doxycycline and test-based prevention were shown to have comparable performance, which is superior to condom-based prevention, especially in the long term.…”

Section: Discussionmentioning

confidence: 99%

Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention

Hahn,

Frickmann,

Loderstädt

2024

EuJMI

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BackgroundDoxycycline-based prevention of bacterial sexually transmitted infections (STIs) has been assessed in various studies and has been recommended by the European AIDS Clinical Society to be proposed to persons with repeated STIs on a case-by-case basis. However, while good preventive effects could be shown for Chlamydia trachomatis and Treponema pallidum in Europe, no reliable prevention against doxycycline resistance-affected bacterial causes of STIs like Neisseria gonorrhoeae and Mycoplasma genitalium was confirmed.MethodsIn a modelling-approach, we assessed potential beneficial effects even against the latter microorganisms in case of optimized adherence with doxycycline prevention. These effects were modelled for Germany in comparison to traditional prevention schemes like condom-based STI-prevention and testing-as-prevention.ResultsWith estimated risk reduction in the ranges of 86% for N. gonorrhoeae and of 82% for Mycoplasma genitalium, expectable preventive efficacy similar to alternative preventive approaches could be calculated in case of optimized adherence with doxycycline prevention. In case of repeated risk exposure, the preventive potential of condom-based prevention was decreased compared to both optimized doxycycline prevention and testing-as-prevention.ConclusionsAs suggested by the applied modelling, the preventive effect of optimized doxycycline prevention against bacterial STIs is in a similar range, like other common prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention

Hahn,

Frickmann,

Loderstädt

2024

EuJMI

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“…On the contrary, the availability of STIs’ data in non-EU/EEA countries is more limited, with an inconsistent collection of information on modes of transmission, hindering comparability with EU/EEA data and conclusions about STI epidemics. However, data collected from national statistical reports in such non-EU/EEA countries indicate a steady syphilis decline [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Atypical Manifestations of Syphilis: A 10-Year Retrospective Study

Ciccarese,

Facciorusso,

Mastrolonardo

et al. 2024

JCM

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Background: The incidence of syphilis has increased in high-income countries in the past few decades, especially among men who have sex with men. In the present study, we aimed to analyze the correlations between atypical syphilis manifestations and the demographic, clinical, and laboratory features of patients and to review unusual presentations of syphilis reported in the literature. Methods: We conducted a retrospective analysis of 307 patients with syphilis diagnosed between 1 January 2013 and 31 October 2023 at the sexually transmitted infection (STI) centers of the University of Genoa and University of Foggia with both typical and atypical manifestations of disease. Results: In our series, atypical manifestations were detected in 25.8% of the patients, especially in the secondary stage of the disease. Lesions with annular morphology and lesions presenting as itchy erythematous scaly plaques with a psoriasiform appearance were the most common atypical presentations of secondary syphilis. A statistical analysis revealed that homosexual orientation, syphilis reinfection, and venereal disease research laboratory (VDRL) titers > 1:32 were correlated with atypical manifestations. Conclusions: Our study demonstrates that the spectrum of syphilis manifestations, in all the stages of the disease, is wide; atypical manifestations often pose diagnostic challenges, may delay the provision of appropriate treatment, and facilitate the spread of the infection.

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“…The incidence of syphilis has increased markedly in Europe and high-income countries since 2000, with the highest rise observed among men who have sex with men. 1 Systemic dissemination of T pallidum can lead to neurosyphilis through invasion of the CNS, whereas in pregnant women, mother-to-child transmission can cause fetal loss, stillbirth, and congenital infection in newborns resulting in long term sequelae. 2 , 3 …”

Section: Introductionmentioning

confidence: 99%

Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial

Ubals,

Nadal-Baron,

Arando

et al. 2024

The Lancet Infectious Diseases

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Epidemiology and determinants of reemerging bacterial sexually transmitted infections (STIs) and emerging STIs in Europe

Cited by 17 publications

References 104 publications

Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention

Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention

Atypical Manifestations of Syphilis: A 10-Year Retrospective Study

Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial

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