Epidemiology and Clinicopathology of Aortic Dissection

Mészarós, István; Mórocz, József; Szlávi, József; Schmidt, J; Tornóci, László; Nagy, László; Szép, L

doi:10.1378/chest.117.5.1271

Cited by 892 publications

(573 citation statements)

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“…1c). The relationship between the mean signal SI in gray level and the instantaneous flow velocity IF is provided by Equation [1] for the ascending aorta and Equation [2] for the descending aorta.…”

Section: Image Analysismentioning

confidence: 99%

“…THORACIC AORTIC ANEURYSMS and/or aortic dissections (TAAD) are an important cause of death (1,2) and familial cases could account for 15 to 20% of all cases (2,3). Among the heterogenous TAAD genetic predispositions a new syndrome was described in a large family, namely the "Bourgogne family," associating TAAD with patent ductus arteriosus (PDA) (3), that was linked to a single locus at 16p12.1-p13.…”

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confidence: 99%

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Compliance and pulse wave velocity assessed by MRI detect early aortic impairment in young patients with mutation of the smooth muscle myosin heavy chain

Lalande

Kien

Walker

et al. 2008

Magnetic Resonance Imaging

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Purpose:To evaluate aortic elasticity with MRI on young asymptomatic individuals with mutation of the smooth muscle myosin heavy chain in whom aortic enlargement is not present. Materials and Methods:Aortic compliance, aortic distensibility, and pulse wave velocity (PWV) were semiautomatically measured from MRI in 8 asymptomatic subjects having a mutation of the MYH11 gene (Mϩ) and 21 nonmutated relatives (MϪ) of similar age, sex, and blood pressure characteristics.Results: Despite a similar aortic diameter in both groups, the aortic compliance and distensibility were significantly lower in Mϩ subjects compared with MϪ (0.84 Ϯ 0.33 versus 2.03 Ϯ 0.54 mm 2 /mmHg, 1.18 Ϯ 0.62 10 Ϫ3 versus 5.11 Ϯ 1.58 10 Ϫ3 mmHg Ϫ1 , respectively), and PWV was significantly higher (5.35 Ϯ 1.53 versus 3.60 Ϯ 0.64 m.s Ϫ1 ). A threshold aortic compliance value of 1.3 mm 2 /mmHg separated the two groups. The receiver operating characteristics curve analysis indicated an optimal threshold of 2.9 10 Ϫ3 mmHg Ϫ1 for aortic distensibility (sensitivity: 87.5%, specificity: 90%), and of 4.4 m.s Ϫ1 for PWV (sensitivity: 75%, specificity: 100%). Conclusion:Young asymptomatic adults with MYH11 mutation have an aortic compliance impairment which is not detectable by the sole measurement of the aortic size. Aortic compliance measurement might be part of routine examination in patients suspected of inherited aortic disease even with a normal aortic diameter.

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Section: Image Analysismentioning

confidence: 99%

mentioning

confidence: 99%

Compliance and pulse wave velocity assessed by MRI detect early aortic impairment in young patients with mutation of the smooth muscle myosin heavy chain

Lalande

Kien

Walker

et al. 2008

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…He evolved with appropriate blood pressure control. DISCUSSION Acute aortic dissection (AAD) -secondary to hypertension -was reported as hypertensive emergency, characterized by sudden separation of the median layer of the vessel, causing infiltration of a column of blood in a virtual space formed between the intima and adventitia, creating a false lumen and causing hematoma formation [1].…”

Section: Fig 1 -Aortography Showing Double-lumen Image In Descendingmentioning

confidence: 99%

“…AAD results in high mortality rates and may reach levels from 21.4% before admission to 75.0% in the first 48 hours [1]. About 70% of the cases are positioned in the ascending aorta, while 20% are in the descending and 10% are in the transverse aorta [1].…”

Section: Fig 1 -Aortography Showing Double-lumen Image In Descendingmentioning

confidence: 99%