Epidemiology and clinical presentation of a seasonal ataxia in Western Nigeria

Adamolekun, B; Ndububa, DA

doi:10.1016/0022-510x(94)90017-5

Cited by 13 publications

(6 citation statements)

References 5 publications

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“…Early thiamine administration can reverse symptoms within 72 hours. Health education campaigns focused on raising awareness among hospital workers, hospitalized patients, and their relatives have been effective in reducing the prevalence of seasonal ataxia …”

Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 99%

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Whitfield

Bourassa

Adamolekun

et al. 2018

Annals of the New York Academy of Sciences

231

335

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Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.

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Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 99%

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Whitfield

Bourassa

Adamolekun

et al. 2018

Annals of the New York Academy of Sciences

231

335

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show abstract

“…The larvae may contain a thiaminase which lowers thiamine to deficient levels. 6,7 The most likely explanation for cases 1 and 2 is increased thiamine metabolism owing to pyrexia and increased thiamine requirement for the metabolism of the large quantity of carbohydrate provided during admission in the form of high-concentration dextrose.4 Undernutrition and probable preexisting thiamine deficiency appeared to be the underlying predisposing factors common to these four children.…”

Section: Discussionmentioning

confidence: 98%

“…3 Thiamine deficiency (beriberi) can arise from an inadequate intake, poor absorption or destruction by heat, alkali and thiaminase-containing foods such as raw fish and the larvae of Anaphe venata, a local delicacy in Ijesaland, south-western Nigeria, known as kanni. [4][5][6] Thiamine is lost from cereals during milling and cooking, especially when they are cooked with baking powder. 4 Local customs and practices in processing and cooking cereals therefore influence the incidence of beriberi.…”

mentioning

confidence: 99%

Thiamine deficiency: a cause of childhood ataxia not to be ignored

Ogunlesi

2004

Annals of Tropical Paediatrics

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We report four cases of childhood ataxia with and without encephalopathies which were successfully managed with thiamine supplementation and diagnosed in retrospect as being caused by thiamine deficiency. The clinical presentations were similar to those previously reported amongst adolescents and adults who ingested the larvae of Anaphe venata, a local delicacy among the Ijeshas of south-western Nigeria, during the rainy season. This has been called seasonal ataxia syndrome. The cases were of interest because the disorder was not described in children in the previous report, which might indicate a worsening nutritional status in these communities. This report is to alert child health physicians in the developing world to the possibility of a pre-existing thiamine deficiency progressing into ataxic disorders when certain foods are ingested.

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“…Em Cuba, constatou-se associação significativa entre a neuropatia epidêmica de 1991-1993 e o hábito de fumar, indicando que o fator tóxico do fumo, associado a deficiências nutricionais, poderia facilitar a expressão clínica da enfermidade 5,16 . Ademais, inúmeros estudos têm evidenciado associação entre alcoolismo e fumo à deficiência de tiamina 1,2,16,23,24 .…”

Section: Discussionunclassified

Perfil epidemiológico do beribéri notificado de 2006 a 2008 no Estado do Maranhão, Brasil

et al. 2011

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O objetivo do estudo foi descrever o perfil epidemiológico dos casos e óbitos de beribéri notificados de 2006-2008 no Estado do Maranhão, Brasil. Informações foram obtidas de fichas de notificação da Secretaria de Estado da Saúde do Maranhão e utilizou-se o Índice Global de Moran para avaliar autocorrelação espacial. Foram notificados 1.207 casos e 40 óbitos. Regiões oeste e central mostraram forte presença de autocorrelação espacial da incidência. Ocorrência de casos e óbitos concentrou-se de maio a agosto, em homens jovens (20-40 anos). Hábito de consumir álcool e fumar esteve presente entre os óbitos; baixa renda e ocupação com atividade pesada, entre os casos. Os sintomas mais comuns foram diminuição da força, dormência e edema das pernas, dificuldade para caminhar e dor na panturrilha. O perfil dos acometidos e os sintomas, exceto edema de membros inferiores, são característicos de beribéri seco. É pertinente que estudos sobre seu ressurgimento no país sejam aprofundados.

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Epidemiology and clinical presentation of a seasonal ataxia in Western Nigeria

Cited by 13 publications

References 5 publications

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Thiamine deficiency: a cause of childhood ataxia not to be ignored

Perfil epidemiológico do beribéri notificado de 2006 a 2008 no Estado do Maranhão, Brasil

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