Epidemiology and Clinical Presentation in Esophageal Cancer

Mudan, Satvinder; Kang, Jin-Yong

doi:10.1017/cbo9780511545443.003

Cited by 10 publications

(9 citation statements)

References 77 publications

(49 reference statements)

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“…It is the sixth most common cause of cancer death, estimated to have claimed the lives of 406 000 people in 2008 . Of the two main histopathological categories for EC, esophageal adenocarcinoma (EAC) predominates in the Caucasian population and ESCC is more frequent in Asians and Africans . In the last three decades, while the relative incidence rate of EAC in western countries has overtaken that of ESCC, the absolute incidence of SCC has remained stable and of the two subtypes, ESCC still accounts for most esophageal malignancies worldwide…”

Section: Epidemiology Of Esccmentioning

confidence: 99%

Role of human papillomaviruses in esophageal squamous cell carcinoma

Liyanage¹,

Segelov

Garland

et al. 2012

Asia-Pac J Clncl Oncology

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Esophageal cancer (EC) is responsible for almost half a million deaths worldwide annually and has a multifactorial etiology, which may account for its geographical variation in incidence. In the last 30 years the potential of human papillomaviruses (HPV) as oncogenes or co-factors in the tumorigenic process of esophageal squamous cell carcinoma (ESCC) has been widely studied. While the etiology of HPV in cervical and certain other anogenital and aerodigestive cancers has been established, results regarding its role in EC have been largely inconclusive. A causal association can be evaluated only with a case-control study, where normal controls are compared to ESCC cases for the presence of HPV. We reviewed all studies investigating ESCC tissue for HPV DNA and identified 139 that met our inclusion criteria, of which only 22 were case-control studies. Our results support previous findings of higher levels of HPV detection in high-risk ESCC regions than in areas of low risk. In addition, we confirm that the role of HPV in ESCC remains unclear, despite an accumulation of studies on the subject. The variations in investigative technique, study design and sample types tested may account for the lack of consistency in results. There is a need for a meta-analysis of all case-control studies to date, and for large, well-designed case-control studies with adequate power to investigate the association. The potential benefits of prophylactic HPV vaccines could be evaluated if HPV is identified as an etiological factor in EC, highlighting the need for further research in this area.

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Section: Epidemiology Of Esccmentioning

confidence: 99%

Role of human papillomaviruses in esophageal squamous cell carcinoma

Liyanage¹,

Segelov

Garland

et al. 2012

Asia-Pac J Clncl Oncology

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“…Сохраняющийся интерес к теоретическим и клиническим аспектам проблемы определяется неуклонным ростом заболеваемости аденокарциномой пищевода у жителей экономически развитых стран, отмечающийся с 80-х годов XX в. [1,5,6,11,12].…”

Section: опыт работыunclassified

Antireflux Resection of Mucous Membrane of Esophagogastric Anastomosis in Treatment of Barrett’s Esophagus: Initial Experience

Смирнов

Vasilevskiy

Lapshin

et al. 2016

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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“…Of the main histologic subtypes of OC, OSCC accounts for the majority of oesophageal malignancies worldwide and is the predominant form of OC diagnosed in African and Asian countries [16,17].…”

Section: Oesophageal Squamous Cell Carcinomamentioning

confidence: 99%

The Relationship between Human Papillomavirus and Oesophageal Squamous Cell Carcinoma in China—A Review of the Evidence

Liyanage¹,

Li²,

Yang³

et al. 2013

AID

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Background: China has one of the highest incidence rates of oesophageal cancer in the world. The role of human papillomavirus (HPV) has been extensively researched in oesophageal squamous cell carcinoma (OSCC) with indeterminate results. The majority of these studies have been conducted in the Chinese population. Evidence for a definitive HPV-OSCC association could potentially support prophylactic vaccination in target populations, highlighting the need for ongoing investigation. The aim of this review is to summarise the findings of HPV DNA in OSCC tissue in Chinese subjects, with a view to informing further research in this area. Methods: A systematic literature search of the Chinese National Knowledge Infrastructure (CNKI) database, Medline, Embase and PubMed was conducted for all studies in English and Chinese language, examining OSCC tissue for HPV DNA in China. Reference lists of retrieved articles were reviewed and hand searches of relevant, key journals were conducted, to source articles which were not electronically indexed. Sixty-four studies met our selection criteria. Data from case-control and cross-sectional studies were analysed separately for any HPV-OSCC association, using the Epi Info ™ 3.5.3 software program. Results: From all studies conducted in the Chinese population, 2166/5953 (36%) of all OSCC tissue and 478/1684 (28%) of healthy control tissue, tested positive for HPV. We found that 11/16 case-control and cross-sectional studies had a statistically significant crude odds ratio, which supported a potential HPV-OSCC association. The largest study, carried out in the high incidence County of Anyang in Henan Province, reported 207/265 (78%) OSCC tissues testing positive for HPV DNA against 203/357 (57%) controls and had an unadjusted odds ratio of 2.71 (p-value < 0.0001). Conclusion: A rigorous meta-analysis would improve interpretation of the data and a well-designed large-scale case-control study is warranted. If a link is found between HPV and OSCC, prophylactic HPV vaccines could be of significant benefit in China.

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Epidemiology and Clinical Presentation in Esophageal Cancer

Cited by 10 publications

References 77 publications

Role of human papillomaviruses in esophageal squamous cell carcinoma

Role of human papillomaviruses in esophageal squamous cell carcinoma

Antireflux Resection of Mucous Membrane of Esophagogastric Anastomosis in Treatment of Barrett’s Esophagus: Initial Experience

The Relationship between Human Papillomavirus and Oesophageal Squamous Cell Carcinoma in China—A Review of the Evidence

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