Epidemiology and clinical outcome of enterococcal bacteraemia in an acute care hospital

Poh, Christina; Oh, H. M. L.; Tan, A.

doi:10.1016/j.jinf.2005.07.011

Cited by 52 publications

(35 citation statements)

References 12 publications

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“…Surgical procedures such as vascular catheterization are associated with episodes of bacteremia. In a study performed at an acute-care hospital to determine the epidemiology of bacteremia, it was observed that vascular catheterization preceding the onset of bacteremia was performed on 23.8% of patients with subsequent enterococcal bacteremia [36]. Other authors have also investigated the impact of arterial catheters on patients with bacteremia.…”

Section: Discussionmentioning

confidence: 99%

Clinical and microbiological features of bacteremia caused by Enterococcus faecalis

Ceci

Delpech

Sparo

et al. 2015

J Infect Dev Ctries

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Introduction: Enterococcus faecalis is a frequent etiologic agent of invasive infections in hospitalized patients. The aim of this study was to analyze clinical and microbiological features of bacteremia caused by E. faecalis. Methodology: Between 2011 and 2013, significant bacteremia caused by E. faecalis in hospitalized patients was studied. Patient characteristics, comorbid conditions, and 14-day mortality were recorded. Virulence genes esp, gelE, and cylA; opsonophagocytosis resistance; resistance to bactericidal effect of normal serum; beta lactamase production; and susceptibility to ampicillin, vancomycin, teicoplanin, gentamicin, and streptomycin were investigated. Results: E. faecalis strains were recovered from 33 bacteremic patients. Polymicrobial bacteremia was diagnosed in 2 patients; 10 patients died. Virulence genes were found in strains from both deceased patients and survivors. Sources of bacteremia included urinary tract infections (36.4%), vascular catheters (15.1%), abscesses (9.1%), and unknown (48.5%). Underlying diseases included cancer (30.3%), diabetes (36.4%), cirrhosis (6.1%), renal (36.4%), and chronic obstructive pulmonary disease (2.0%). Co-morbidities included alcohol use (26.1%); glucocorticoid therapy (19.0%); prior antibiotic therapy (60.6%); and central venous (21.2%), arterial (12.1%), and urinary (63.6%) catheters. Also, 57.6% of patients came from the intensive care unit (ICU); 33.3% had mechanical ventilation. Significant mortalityassociated conditions included polymicrobial bacteremia, oncological disease, APACHE II score ≥ 20, ICU stay, renal disease, central venous catheter, and mechanical ventilation. Conclusions: Outcome of patients was associated with their status and not with the presence of virulence genes in E. faecalis strains. A significant percentage of bacteremia had undetermined origin. An alternate origin may be the gastrointestinal tract, through translocation.

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Section: Discussionmentioning

confidence: 99%

Clinical and microbiological features of bacteremia caused by Enterococcus faecalis

Ceci

Delpech

Sparo

et al. 2015

J Infect Dev Ctries

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“…Enterokok türleri başta idrar yolu infeksiyonları olmak üzere endokardit, cerrahi yara infeksiyonları, hepatobiliyer sepsis, bakteriyemi ve neonatal sepsise sebep olabilirler (1). Tüm idrar yolu infeksiyonlarının %10'undan, nozokomiyal idrar yolu infeksiyonlarının yaklaşık %16'sından sorumludurlar (2).…”

Section: Introductionunclassified

Antimicrobial Resistance of Enterococci Isolated From Urine Cultures

Yenişehirli¹,

Yenişehirli²,

Bulut³

et al. 2016

Klimik Dergisi

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Objective: The aim of this study was to determine the susceptibility of enterococcal strains isolated from both nosocomial and community-acquired urinary tract infections between January 2011 and December 2014, and also to compare the resistance rates between January 2011-December 2012 and January 2013-December 2014 periods. Methods: The identification of the strains and antimicrobial susceptibility rates were determined by BD Phoenix (Becton, Dickinson and Company., Sparks, Maryland, USA) and VITEK ® 2 (bioMérieux, Marcy l'Etoile, Fransa) automatized systems. Results: All isolates (n=156) were found to be susceptible to vancomycin, teicoplanin, linezolid and tigecycline. Penicillin, ampicillin, ciprofloxacin, nitrofurantoin, tetracycline, fosfomycin, gentamicin (high-level) and streptomycin (high-level) resistance rates were 60.9, 8.7, 15.2, 4.3, 73.9, 6.5, 15.2 and 26.1% in nosocomial Enterococcus faecalis isolates (n=46), respectively; and 100, 100, 28.6, 65.7, 42.9, 8.6, 17.1 and 31.4% in nosocomial E. faecium isolates (n=35), respectively. Comparison of data between January 2011-December 2012 and January 2013-December 2014 periods revealed significant increases in resistance rates to penicillin, ciprofloxacin, and streptomycin (high-level) in nosocomial E. faecalis isolates and to ciprofloxacin and streptomycin (high-level) in nosocomial E. faecium isolates. In community-acquired E. faecalis isolates, the resistance rates for penicillin and ciprofloxacin were found to be increased in the second period of the study. Conclusions: High-level aminoglycoside and quinolone resistance rates in enterococci were significantly increased in our hospital. Results of antimicrobial susceptibility testing are important for choosing appropriate treatment.

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“…For instance, bacteraemia caused by S. aureus, 38,39 Enterococci, 40 and Klebsiella sp. ; 41,42 hepatic abscess and fascial space infection of the head and neck and soft tissue due to Klebsiella pneumoniae.…”

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confidence: 99%