Epidemiology and clinical features of atopic dermatitis in India

Kanwar, Amrinder J.; De, Dipankar

doi:10.4103/0019-5154.87112

Cited by 32 publications

(30 citation statements)

References 18 publications

(40 reference statements)

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“…Interventions aimed at reducing exposure to or harmful sequelae from environmental triggers of AD could prevent or mitigate disease. The prevalence of AD appears to be higher in wealthier, developed regions compared with developing regions [2,[35][36][37][38][39][40][41][42][43][44]. Moreover, the prevalence of AD dramatically increased over the past 50 years worldwide and continues to increase in a number of countries [1,45].…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

268

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Environmental Risk Factorsmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

268

225

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“…Diagnostic and therapeutic implications of chronic skin diseases as well as cellular and molecular mechanisms are less certain. AD with about 11%of prevalence is one of the important diseases which appears to be increasing [118,119].…”

Section: Expert Commentary and Five-year Viewmentioning

confidence: 99%

Atopic dermatitis-associated protein interaction network lead to new insights in chronic sulfur mustard skin lesion mechanisms

Amiri

Jafari

Jamalkandi

et al. 2013

Expert Review of Proteomics

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Chronic sulfur mustard skin lesions (CSMSLs) are the most common complications of sulfur mustard exposure; however, its mechanism is not completely understood.According to clinical signs, there are similarities between CSMSL and atopic dermatitis (AD). In this study, proteomic results of AD were reviewed and the AD-associated protein-protein interaction network (PIN) was analyzed. According to centrality measurements, 16 proteins were designated as pivotal elements in AD mechanisms. Interestingly, most of these proteins had been reported in some sulfur mustard-related studies in late and acute phases separately. Based on the gene enrichment analysis, aging, cell response to stress, cancer, Toll- and NOD-like receptor and apoptosis signaling pathways have the greatest impact on the disease. By the analysis of directed protein interaction networks, it is concluded that TNF, IL-6, AKT1, NOS3 and CDKN1A are the most important proteins. It is possible that these proteins play role in the shared complications of AD and CSMSL including xerosis and itching.

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“…9 A gradual increase in the prevalence of AD has been observed recently and the upward trend is also true in Indian context. 10 AD is the commonest dermatosis in children registered in paediatric dermatology clinic where it constituted 28.46% of all registered patients. 11 Numerous…”

Section: Discussionmentioning

confidence: 99%

Atopic dermatitis in children: a clinico epidemiological study and the role of dietary restrictions in disease severity

2017

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Background: Atopic dermatitis is chronic or chronically relapsing inflammatory dermatoses. Immune sensitization to food derived allergens play an important role in its pathogenesis. Aim of this study was to assess the clinical and epidemiological aspects of atopic dermatitis in children below 12 years of age, the role played by dietary modifications in the severity of disease and to correlate serum IgE levels with clinical severity and dietary modifications.Methods: Seventy five patients, diagnosed as atopic dermatitis in age group of 1-12 years who attended Dermatology department in a tertiary care hospital during a 1 year period were selected. The clinico epidemiological features were noted. Patients were asked to avoid milk, egg and food containing milk and egg and other precipitating food for 3 weeks. SCORAD index and serum IgE levels was assessed initially and after 3 weeks..Results: Of the 75 children with atopic dermatitis majority had pruritus and typical morphology of lesions .It was seen that 44% had food as their main precipitant; 26.7% inhalants, 22.7% seasonal variations and 6.7% had other precipitants including alternative medication. Mean SCORAD index of the cases and mean serum IgE values were decreased after 3 weeks of dietary restrictions. Conclusions: Food was found to be the major precipitant, followed by inhalants, seasonal variations and other medications. Egg, fish and milk were found to be the major precipitants amongst food. There was a decline in SCORAD index and mean serum IgE after 3 weeks of dietary restriction.

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Epidemiology and clinical features of atopic dermatitis in India

Cited by 32 publications

References 18 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Atopic dermatitis-associated protein interaction network lead to new insights in chronic sulfur mustard skin lesion mechanisms

Atopic dermatitis in children: a clinico epidemiological study and the role of dietary restrictions in disease severity

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