Epidemiology and Clinical Features of Vestibular Schwannoma in Manitoba, Canada

Frohlich, A M; Sutherland, Garnette R.

doi:10.1017/s0317167100047685

Cited by 24 publications

(13 citation statements)

References 22 publications

(10 reference statements)

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“…The incidence in Denmark is also higher than Finland, Norway, and Sweden [14]. An incidence similar to the US was found in a Canadian study [12]. International differences in vestibular schwannoma incidence may be due to different genetic and/or environmental factors or due to differences in diagnostic practices.…”

Section: Study Interpretationsupporting

confidence: 50%

“…We believe this represents the most accurate and complete estimate of the incidence of vestibular schwannoma in the US to date. The incidence of vestibular schwannomas varies internationally [11][12][13][14][15][16][17][18][19][20]. International rates are age-adjusted to the world standard million and cannot be directly compared to rates adjusted to the US standard million.…”

Section: Study Interpretationmentioning

confidence: 99%

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Incidence of vestibular schwannomas in the United States

et al. 2015

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There is a paucity of population-based data evaluating the incidence of vestibular schwannomas according to age, gender, race, and ethnicity. Such data are necessary to assess the burden of vestibular schwannomas on varying populations and to inform future research and healthcare planning. The Central Brain Tumor Registry of the United States, which contains the largest aggregation of population-based data on the incidence of primary central nervous system tumors in the US, was used. Age-adjusted incidence rates and incidence rate ratios (IRR) of vestibular schwannomas from 2004 to 2010 were calculated by age at diagnosis, gender, race, and ethnicity. Annual percent change (APC) was calculated using Joinpoint to characterize temporal trends. From 2004 to 2010, there were 23,729 newly diagnosed vestibular schwannomas in the US; overall incidence was 1.09 per 100,000 population. Incidence was stable over time (APC -0.41 %, 95 % confidence interval -3.4, 2.7). Incidence increased with age to a peak of 2.93 per 100,000 in the 65-74 year old age group. Overall, there was no difference in incidence by gender. Compared to Whites, incidence was highest in Asian Pacific Islanders (IRR 1.37, p < 0.001) and lowest in African Americans (IRR 0.36, p < 0.001). Incidence was lower in Hispanics than non-Hispanics (IRR 0.69, p < 0.001). Over 3300 vestibular schwannomas are diagnosed per year in the US and incidence is 1.09 per 100,000 population. Incidence increases with age up to the 65-74 year old age group. Incidence is higher in Asian Pacific Islanders and lower in African Americans and Hispanics.

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Section: Study Interpretationsupporting

confidence: 50%

Section: Study Interpretationmentioning

confidence: 99%

Incidence of vestibular schwannomas in the United States

et al. 2015

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“…One autopsy study 2 suggests that acoustic neuromas may be present in 2.4% of individuals dying from unrelated causes. This histologic incidence greatly exceeds the incidence of symptomatic tumors, which has been estimated as about 1 new case per 100,000 population per year 3‐5 …”

Section: Introductionmentioning

confidence: 95%

Surgical Treatment of Acoustic Neuroma (Vestibular Schwannoma) in the United States

Wiegand

Ojemann

Fickel³

1996

The Laryngoscope

151

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“…Several other studies have also published data showing an increasing incidence rate of VS. Generally, incidences between 10 and 20 VS/million/year are reported, including data from America (Nestor et al8), Canada (Frohlich and Sutherland9), United Kingdom (Evans et al10) and locally in Denmark (Mirz et al11). Lately, American population-based registry studies have found similar incidences.…”

Section: Introductionmentioning

confidence: 99%

<p>Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort</p>

Reznitsky

Petersen

West

et al. 2019

CLEP

109

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ObjectiveReports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark since 1976.Study-designData on gender, age, tumor localization and size registered during the period 1976–2015 were retrieved.Results3637 new cases of VS were diagnosed during the 40-year period. The annual number of diagnosed VS increased from 14 in 1976 to 193 in 2015. Mean extrameatal tumor size decreased from 26mm in 1976 to 13.4mm in 2015. Large and giant tumors were more frequent during the first decades, whereas predominantly smaller tumors were diagnosed during the recent years. Median age at diagnosis increased gradually from 49.2 years in 1976 to 60 years in 2015.ConclusionOver the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people. Concurrently, the diagnostic tumor size has decreased from 26mm to 7mm, and the age at diagnosis has increased from 49 to 60 years.

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Epidemiology and Clinical Features of Vestibular Schwannoma in Manitoba, Canada

Abstract: ABSTRACT:The incidence of vestibular schwannoma (acoustic neuroma) in Manitoba, Canada was reviewed. From 1987 through 1991, 71 tumors were diagnosed in 69 patients. The overall annual incidence rate for both sexes was

Cited by 24 publications

References 22 publications

Incidence of vestibular schwannomas in the United States

Incidence of vestibular schwannomas in the United States

Surgical Treatment of Acoustic Neuroma (Vestibular Schwannoma) in the United States

<p>Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort</p>

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