Epidemiology and Clinical Features of Coronavirus disease 2019 in Children

Choi, Soo-Han; 김한울,; 강지만,; Kim, Dong Hyun; 조은영,

doi:10.14776/piv.2020.27.e10

Cited by 63 publications

(111 citation statements)

References 13 publications

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“…The most common symptoms are fever and dry cough, as in adults [11,13,18,19]. Gastrointestinal symptoms may also accompany mostly in children [7,20]. When our patients were asked about the complaints, it was noticed that the musculoskeletal system symptoms were in the foreground.…”

Section: Discussionmentioning

confidence: 89%

“…The current epidemiological studies show that children primarily contract the disease through household exposure, but rarely vice versa [19][20][21]. The incubation period may differ in adults and children, making it challenging to identify the primary source [22].…”

Section: Discussionmentioning

confidence: 99%

“…The group of subjects with vasculitis consisted of patients diagnosed with Behçet's Disease (n=8), Takayasu arteritis (n=2), and Polyarteritis Nodosa (PAN) (n=1) with a median age of 16 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) years. Seven (63.6%) were male.…”

Section: Demographic and Clinical Characteristics Of Patientsmentioning

confidence: 99%

“…The median disease duration was 41 (3-125) months. The duration of immunosuppressive treatments was azathioprine (n=9, 81.8%) for 10 (2-36) months; mycophenolate mofetil (n=1, 9.1%) for 8 months; methotrexate (n=2, 18.2%) for 14.5 (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20); etanercept (n=1, 9.1%) for 16 months and in iximab (n=2, 18.2%) for 6.5 (5-8) months. Concomitant use of colchicine was noted in 10 patients ( 90.9%).…”

Section: Demographic and Clinical Characteristics Of Patientsmentioning

confidence: 99%

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The impact of COVID-19 pandemic on pediatric rheumatology patients under immunosuppressive therapy: A single-center experience

Köker

Demirkan

Kayaalp

et al. 2020

Preprint

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Objective: The aim of the research was to further broaden current knowledge of whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) entails a risk for children with rheumatic diseases regarding immunosuppressive treatment.Methods: Telephone-survey was administered by conducting interviews with the parents. A message containing a link to the actual questionnaire was sent to their phones simultaneously. The medical records of the patients were reviewed for gathering information about demographic data, clinical follow-up, and treatments.Results: Patients who were followed up with immunosuppressive treatment (n=439) were attempted to be contacted between 1 May 2020 and 15 May 2020. The diagnostic distribution of patients who were accessible and eligible for the study was as follows; juvenile idiopathic arthritis (JIA) (n=243, 58.7%), autoinflammatory diseases (n=109, 26.3%), autoimmune connective tissue diseases (n=51, 12.3%) and vasculitis (n=11, 2.7%). In the entire cohort, the mean age was 12 ± 4.7 years, and 54.1% (n=224) of the patients were female. One patient with seronegative polyarticular JIA, previously prescribed methotrexate and receiving leflunomide during pandemic has been identified to be diagnosed with COVID-19. None of the patients, including the patient diagnosed with COVID-19, had any severe symptoms. More than half of the patients with household contacts required hospitalization as they were asymptomatic.Conclusion: Although circumstances such as compliance in social distancing policy, transmission patterns, attitude following contact may influence the results, immunosuppressive treatment does not seem to pose additional risk in terms of COVID-19.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Demographic and Clinical Characteristics Of Patientsmentioning

confidence: 99%

Section: Demographic and Clinical Characteristics Of Patientsmentioning

confidence: 99%

See 2 more Smart Citations

The impact of COVID-19 pandemic on pediatric rheumatology patients under immunosuppressive therapy: A single-center experience

Köker

Demirkan

Kayaalp

et al. 2020

Preprint

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“…Stressor such as temporary separation from their caregivers, social isolation, loneliness and fears of the aggravation of the disease might push them into a state of crisis, which will not disappear immediately after discharge [7,8]. In addition, pediatric cases were generally characterized as familial cluster and parents of hospitalized children are exposed, as never before, to enormous stress and psychological distress [9,10]. Parental psychological response was found to be highly associated with well-being of the children [11].…”

Section: Introductionmentioning

confidence: 99%

Behavioral Problems of Pediatric Recovered Patients Infected with COVID-19 in Wuhan, China

Xiao¹,

Qi²,

Mei³

et al. 2020

Preprint

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Background: Coronavirus disease 2019 (COVID-19) is profoundly affecting lives around the globe, and up to now, a large of patients have clinically recovered from their initial illness. As the vulnerable population to adverse events, the effect of the COVID-19 outbreak on pediatric recovered patients are of great concern, but relevant researches are limited. We aimed to investigate the prevalence of behavioral problems among pediatric patients with COVID-19 infection after discharge. Methods: A total of 122 children who were suspected or confirmed COVID-19 cases and hospitalized for treatment were enrolled in the study between April 2020 and May 2020 in Wuhan, China. We collected related information about hospitalization and discharge for the children and emotional symptoms for their parents through electronic medical records and questionnaire. The behavioral problems for children were examined applying the parent-reported the Strengths and Difficulties Questionnaire (SDQ).Results: The participant children were discharged from hospital for about two months. Among them, 76 (62%) were boys, and the mean age were 6.71 years old. The highest prevalence of behavioral problems among pediatric children with COVID-19 was 15% (prosocial behavior), followed by 13% (total difficulties), 11% (emotional symptoms), 10% (hyperactivity), 9% (conduct problems), and 1% (peer problems). With regarding to their parents, 26% of them reported having anxiety symptoms and 23% having depression symptoms. Compared with children without anxious or depressive parents, the scores of SDQ were higher in children whose parents have emotional problems.Conclusions: The long-term follow up studies on the psychological and behavioral problems of children infected with COVID-19 and their parents are warranted.

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CHARACTERISTICS and considerations in the medical treatment of COVID‐19 in children

Imai

Matsushima

Saitoh

2020

Acute Medicine & Surgery

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It is rare for children to be in serious condition or die from Coronavirus disease 2019 (COVID‐19) caused by the 2019 novel coronavirus (SARS‐CoV‐2) except for those with underlying diseases such as chronic lung disease (including asthma), cardiovascular disease, and immunosuppressive disease. Recently, patients with hyperinflammatory shock have been identified among children who are confirmed to have or are suspected of having SARS‐CoV‐2 infection. The presenting signs and symptoms are characterized by prolonged fever, abdominal pain, and cardiac involvement without any signs of pneumonia on chest computed tomography. However, it is uncertain at this time whether SARS‐CoV‐2 infection affects this syndrome. Compared to adults, quite a few children are asymptomatic even when infected with SARS‐CoV‐2, which could make these children serious sources of infection at home or in medical institutions. Considering these characteristics, it is important to take appropriate precautions during medical examinations and perform infection control in emergency departments to save the lives of both the children and adult patients. Most healthy children are suffering huge stress due to restrictions against going outside and school closures as social means to control infection. It is possible that children are socially isolated when they come to the emergency department, and they might require mental or social support even if they are only complaining about their physical condition. Healthcare providers are required to examine the children’s circumstances carefully and cooperate with workers in other professions appropriately.

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Epidemiology and Clinical Features of Coronavirus disease 2019 in Children

Cited by 63 publications

References 13 publications

The impact of COVID-19 pandemic on pediatric rheumatology patients under immunosuppressive therapy: A single-center experience

The impact of COVID-19 pandemic on pediatric rheumatology patients under immunosuppressive therapy: A single-center experience

Behavioral Problems of Pediatric Recovered Patients Infected with COVID-19 in Wuhan, China

CHARACTERISTICS and considerations in the medical treatment of COVID‐19 in children

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