Epidemiology and Clinical Consequences of Drug-Resistant Tuberculosis in a Guatemalan Hospital

Harrow, Edward M.; Rangel, Josefa M.; Arriega, J. Manuel; Cohen, Isaac; Ruíz, Marta Ileana de Leon Régil; DeRiemer, Kathryn; Small, Peter M.

doi:10.1378/chest.113.6.1452

Cited by 13 publications

(7 citation statements)

References 12 publications

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“…This is similar to reports from Guatemala (30%) [17] and New York (31%) [18], but the resistant rate to at least two drugs was lower in our study (5.7%-10.1%) compared with that of Guatemala (15%) [19] and New York (17%) [20]. In our study, MDR for the two cardinal antituberculous drugs INH and RIF increased 2% (from 8.1% to 10.1%) in the [19,20].…”

Section: Discussionsupporting

confidence: 88%

“…In our study, we failed to find a correlation between drug resistance and age and we did not have patients infected with HIV or who were intravenous drug users. Resistance to two or more antituberculous drugs was an important predictor of treatment failure and accounted for 55% [17] and 35% [24] of the cases in two previous studies of treatment failure. In our study, we experienced similar results, with 46% treatment failure in the 1982-1986 period and 42% failure in the 1992-1996 period for patients with MDR infections.We demonstrated that a few associated underlying diseases were predictors of mortality in both periods.…”

Section: Discussionmentioning

confidence: 96%

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Change in Demographic Picture and Increase of Drug Resistance in Pulmonary Tuberculosis in a 10-Year Interval in Taiwan

et al. 2002

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In the 1992-1996 period, the mean age of patients and number of female patients significantly increased. There were more patients with diabetes mellitus, obstructive airway diseases, cancer other than lung cancer and prior steroid therapy but fewer patients presenting with classic clinical symptoms of TB. In consideration of the high prevalence and increasing rate of single and multiple drug resistance, we recommend an initial four-drug regimen (INH, RIF, EMB, pyrazinamide) for the treatment of pulmonary TB in Taiwan.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 96%

Change in Demographic Picture and Increase of Drug Resistance in Pulmonary Tuberculosis in a 10-Year Interval in Taiwan

et al. 2002

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“…These rates are lower than those from other regions, including southern Taiwan (29%) [15], Guatemala (30%) [16], and New York (31%) [17]. Liaw et al [18] reported that, during the period 1998-2002, 19.0% of TB isolates analyzed at NTUH were resistant to isoniazid, 6.1% were resistant to rifampin, and 15.7% were resistant to ethambutol.…”

Section: Discussionmentioning

confidence: 97%

Extensively Drug‐ResistantMycobacterium tuberculosisduring a Trend of Decreasing Drug Resistance from 2000 through 2006 at a Medical Center in Taiwan

Lai¹,

Tan

Huang

et al. 2008

CLIN INFECT DIS

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“…Although some previous studies suggest that cavitation on chest radiography is a risk factor for MDR-TB (27, 28), a possible explanation is still elusive.…”

Section: Discussionmentioning

confidence: 99%

Drug Resistance Rates of Mycobacterium tuberculosis at a Private Referral Center in Korea

et al. 2007

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The goals of this study were to identify first-line drug resistance in new and previously treated tuberculosis (TB) cases and to determine risk factors for multidrug-resistant TB (MDR-TB) at a private referral center in Korea. All patients with culture-confirmed pulmonary TB over a 2-yr period between July 2002 and June 2004 were prospectively included in this study. In total, 637 patients were included; 512 (80.4%) were new cases, and 125 (19.6%) were previously treated cases. Resistance to at least one first-line drug was identified in 11.7% of new cases and 41.6% of previously treated cases. MDR-TB was detected in 3.9% of new cases and 27.2% of previously treated cases. The proportion of extensively drug-resistant TB among MDR-TB patients was 16.7% (9/54). Factors associated with MDR-TB included age under 45 yr, previous TB treatment, and the presence of cavitation on chest radiography. Rates of first-line drug resistance are high, particularly in previously treated patients, in the private sector in Korea. This underscores the need for an improved control program, coupled with early diagnosis of MDR-TB, to reduce the spread and development of resistance.

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Epidemiology and Clinical Consequences of Drug-Resistant Tuberculosis in a Guatemalan Hospital

Cited by 13 publications

References 12 publications

Change in Demographic Picture and Increase of Drug Resistance in Pulmonary Tuberculosis in a 10-Year Interval in Taiwan

Change in Demographic Picture and Increase of Drug Resistance in Pulmonary Tuberculosis in a 10-Year Interval in Taiwan

Extensively Drug‐ResistantMycobacterium tuberculosisduring a Trend of Decreasing Drug Resistance from 2000 through 2006 at a Medical Center in Taiwan

Drug Resistance Rates of Mycobacterium tuberculosis at a Private Referral Center in Korea

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