Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis

Borssén, Åsa Danielsson; Marschall, Hanns‐Ulrich; Bergquist, Annika; Rorsman, Fredrik; Weiland, Ola; Kechagias, Stergios; Nyhlin, Nils; Verbaan, Hans; Nilsson, Emma; Werner, Mårten

doi:10.1080/00365521.2017.1335772

Cited by 27 publications

(58 citation statements)

References 22 publications

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“…Figure illustrates the proportion of patients in the study according to age at diagnosis divided into five categories of 20‐year age brackets. In keeping with other studies, the majority of patients were diagnosed between the age of 41 and 60 years …”

Section: Resultssupporting

confidence: 87%

Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom

Dyson

Wong

Bigirumurame

et al. 2018

Aliment Pharmacol Ther

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There are significant discrepancies in the care received by patients with autoimmune hepatitis in the UK. A high proportion remains on corticosteroids and there is significant treatment variability. Patients receiving care in transplant centres were more likely to achieve and maintain remission. Overall poor remission rates suggest that there are significant unmet therapeutic needs for patients with autoimmune hepatitis.

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Section: Resultssupporting

confidence: 87%

Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom

Dyson

Wong

Bigirumurame

et al. 2018

Aliment Pharmacol Ther

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“…In fact, these increasing trends have also been observed in other epidemiological studies. For instance, the point prevalence of AIH per 100 000 population increased from 10.7 in 2003 to 17.3 in 2009 in Sweden, even though the methodology was different in these two studies . In South Korea, while the incidence of AIH was stable, the prevalence increased gradually from 2009 to 2013 .…”

Section: Discussionmentioning

confidence: 99%

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Tanaka

Mori

Matsumoto

et al. 2019

Hepatology Research

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Aim Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate their prevalence. We carried out a nationwide, hospital‐based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys. Method We randomly selected health‐care facilities used in the survey from a list of all facilities in Japan. The selection rate was determined according to a stratification based on the facility characteristics and scale. We sent questionnaires to the selected facilities enquiring about the number and sex of patients with AILD who visited the facility in 2016. An identical survey was undertaken for AIH/PBC in 2004 and for PSC in 2007; we carried out a comparative analysis of these data. Results We selected 1793 departments from health centers all over Japan. Of them, 1078 (60.1%) responded to the questionnaires. The number of reported patients with AIH, PBC, and PSC was 8505, 10 847, and 906, respectively, and point prevalence was 23.9 (95% confidence interval, 23.3–24.5) for AIH (8.7 in 2004), 33.8 (33.0–34.6) for PBC (11.6 in 2004), and 1.80 (1.75–1.85) for PSC (0.95 in 2007) per 100 000 population. Male‐to‐female patient ratio of AILD was 1:4.3 for AIH (1:6.9 in 2004), 1:3.9 for PBC (1:7.1 in 2004), and 1:0.88 for PSC (1:1.4 in 2007). Conclusion The current study indicates an increasing trend of prevalence as well as male‐to‐female patient ratio of AILD in Japan.

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“…The diagnosis is based on combination of clinical, serological and histological features and aided by diagnostic scores . Epidemiological studies have been scarce but prior studies report annual incidence rates from 0.7 to 3.0 per 100 000 persons with point prevalence from 8.0 to 42.9 per 100 000 . Many of these studies are single‐centered, with some being population‐based but only a handful covering entire nations .…”

Section: Introductionmentioning

confidence: 99%

Increased incidence of autoimmune hepatitis is associated with wider use of biological drugs

Valgeirsson

Hreinsson

Bjõrnsson

2019

Liver International

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Background & aims Population‐based studies on the epidemiology of autoimmune hepatitis (AIH) are scarce. Drug‐induced AIH (DIAIH) is increasingly recognized in association with immunomodulatory therapy. We aimed to determine the incidence, prevalence and natural history of AIH in a population‐based setting. Methods We collected data of new diagnosis of AIH in Iceland from 2006 to 2015. Cases were identified through search of diagnostic codes and text search for AIH within electronical medical records of all hospitals in Iceland and through records of smooth muscle antibodies (SMA) test results by the only laboratory in the country analyzing SMA. Patients were included in the final analysis if they received the clinical diagnosis of AIH or were started on immunosuppressive therapy. Results The mean annual incidence of AIH in Iceland was 2.2 cases per 100 000 inhabitants. Point prevalence on 31 December 2015 was 27/100 000. The median age at diagnosis was 56 years and 86% of patients were of female gender. DIAIH was suspected in 13 of 71 patients (18%) of which eight cases were related to infliximab. Immunosuppressive treatment was started in all but two patients. At the end of follow‐up (median 4.8 years) 66 of 71 (93%) patients were alive. Conclusion The incidence and prevalence rates of AIH in Iceland are the highest reported so far in a population‐based setting. Higher incidence can partly be explained by the increasing use of biological drugs. Immunosuppressive therapy was very effective in achieving remission and prognosis was favorable.

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Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis

Cited by 27 publications

References 22 publications

Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom

Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Increased incidence of autoimmune hepatitis is associated with wider use of biological drugs

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