Epidemiology and associated factors of atopic dermatitis in Malagasy children

Sendrasoa, Fandresena Arilala; Ranaivo, Irina Mamisoa; Razanakoto, Naina Harinjara; Andrianarison, Malalaniaina; Raharolahy, Onivola; Ratovonjanahary, Volatantely; Sata, Michio; Rakotoarisaona, Mendrika Fifaliana; Ramarozatovo, Lala Soavina; Rabenja, F. Rapelanoro

doi:10.1186/s13223-019-0398-2

Cited by 10 publications

(10 citation statements)

References 19 publications

(17 reference statements)

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“…Specific climatic conditions, in particular low humidity levels and low temperatures, can trigger atopic eczema frequency (AD flare‐up). In the northern hemisphere, newborn exposure to cold and dry seasons—such as autumn and winter—can facilitate AD development 13,14 . Therefore, moderate use of masks, increasing local heat and humidity, could enhance dupilumab effectiveness with face eczema resolution.…”

Section: Discussionmentioning

confidence: 99%

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Facial dermatoses and use of protective mask during Covid‐19 pandemic: A clinical and psychological evaluation in patients affected by moderate–severe atopic dermatitis under treatment with dupilumab

Mazzoletti

Esposto

Veronese

et al. 2022

Dermatologic Therapy

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During the SARS‐COV‐2 pandemic, using face masks became mandatory in many countries. Although evidence suggests that masks can exacerbate several inflammatory skin diseases, few studies focus on their real impact on eczema localized to the face in atopic dermatitis (AD) patients. The aim of this study is to evaluate facial eczema prevalence during pandemic and its psychological impact in AD patients pre‐assessed for systemic treatment and/or in therapy with dupilumab. This study includes 71 patients affected by moderate–severe AD, treated with dupilumab at SCDU of Dermatology in Novara, Italy. We calculated the number of subjects with facial involvement in pre‐ and post‐pandemic periods and the related localization trend. We evaluated, in the two groups, clinical and psychological indicators recorded at each visit and the score modifications during the observational period. No statistically significant differences were observed in facial eczema prevalence, between pre‐ and post‐pandemic periods (p = 0.7618) and in facial eczema remission among the two groups (p = 0.1903). In post‐pandemic period, psychological scores were significantly lower (DLQI and HADS respectively with p < 0.0001 and p = 0.0025) and the reduction in EASI score during observational period was significantly greater (p = 0.0001). Our analysis revealed a potential protective effect of masks on face eczema, suggesting that they could enhance dupilumab efficacy. Face masks, covering sensitive areas, can positively contribute to mental distress in patients with facial eczema, and being associated with a lower allergic diseases incidence may sustain dupilumab in reducing AD severity.

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Section: Discussionmentioning

confidence: 99%

“…In the northern hemisphere, newborn exposure to cold and dry seasons—such as autumn and winter—can facilitate AD development. 13 , 14 Therefore, moderate use of masks, increasing local heat and humidity, could enhance dupilumab effectiveness with face eczema resolution.…”

Section: Discussionmentioning

confidence: 99%

Facial dermatoses and use of protective mask during Covid‐19 pandemic: A clinical and psychological evaluation in patients affected by moderate–severe atopic dermatitis under treatment with dupilumab

Mazzoletti

Esposto

Veronese

et al. 2022

Dermatologic Therapy

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“…These dermatoses affected all age groups. Lifestyle factors linked to urbanization were associated with an increased risk of allergic diseases in Africa [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Clinicoepidemiology of Skin Diseases in Children Seen at the University Hospital Center Morafeno, Toamasina, Madagascar

Ranaivo

Sendrasoa

Andrianarison

et al. 2021

Dermatology Research and Practice

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Introduction. The child’s skin diseases are common and very diverse. Many studies concerning pediatric dermatoses have been carried out in Africa and the rest of the world. Few epidemioclinical data reflect these skin diseases in children, especially in the east coast of Madagascar. We aim to describe the pattern skin diseases among children seen at the University Hospital Center Morafeno, Toamasina, Madagascar. Patients and Methods. A retrospective study over a 3-year period from January 2017 to December 2019 was conducted in children seen in the Dermatology Department of University Hospital Center Morafeno, Toamasina, with skin diseases. Results. During the study period, 347 children out of the 1584 new patients were retained with a sex ratio of 0.86. The mean age was 6.4 years old. The main diseases identified were skin infectious diseases (43, 23%), allergic dermatoses (24.21%), and autonomous dermatosis (15.56%). Conclusion. Our study revealed the importance of infectious and allergic dermatoses in Toamasina. It is necessary to carry out simple preventive actions such as hygiene.

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“…As a result of our search, we proved that different clinical situations (cancer, lupus erythematosus) were accompanied by false-positive tests for syphilis, but we did not find any mention of false-positive test in atopic dermatitis (AD). Meanwhile, the disease is not rare in different countries [85][86][87][88][89][90][91][92]. Now, we present the case.…”

Section: Own Researchmentioning

confidence: 96%

False-Positive Serologic Reactions for Syphilis

Потекаев¹,

Жукова²,

Хамаганова³

2023

Infectious Diseases

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The epidemiologic situation of syphilitic infection warrants attention to diagnostic methods. Nontreponemal tests (rapid plasma regain, Venereal Disease Research Laboratory) are less reliable, as there are certain situations when false-positive reactions for syphilis antibodies may appear. Variable examinations were performed and proved that it was necessary to assess the titer of antibodies, as well as confirmation of the diagnosis by treponemal tests (fluorescent treponemal antibody, treponema pallidum hemagglutination assay, enzyme immunoassay, Western blot), were obligatory. In recent decades, new methods were elaborated (e.g., BioPlex total screen, tests with β2-GPI-dependent anticardiolipin antibody, the ARCHITECT syphilis treponema pallidum chemiluminescent immunoassay, the Elecsys immunoassay (Roche Diagnostics)). We present the review of publications on syphilis serologic diagnostics and present our own research. We did not find any mention of a false-positive test in atopic dermatitis and present a case of false-positive reactions for syphilis in such patients.

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Epidemiology and associated factors of atopic dermatitis in Malagasy children

Cited by 10 publications

References 19 publications

Facial dermatoses and use of protective mask during Covid‐19 pandemic: A clinical and psychological evaluation in patients affected by moderate–severe atopic dermatitis under treatment with dupilumab

Facial dermatoses and use of protective mask during Covid‐19 pandemic: A clinical and psychological evaluation in patients affected by moderate–severe atopic dermatitis under treatment with dupilumab

Clinicoepidemiology of Skin Diseases in Children Seen at the University Hospital Center Morafeno, Toamasina, Madagascar

False-Positive Serologic Reactions for Syphilis

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