Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants

Sung, Rita Y T; Chan, Raymond K. H.; Tam, John S.; Cheng, A. F. B.; Murray, H. G. S.

doi:10.1017/s0950268800049591

Cited by 66 publications

(52 citation statements)

References 19 publications

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“…These conditions are particularly important for the seasonality of viral infections, mainly by RSV (15,(19)(20)(21) , as observed in the present study. The prevalence of positive RSV was 30.7%, being almost 40% in bronchiolitis, similar to that reported in the literature, with 30 to 40% rate of positive RSV in bronchiolitis (22)(23)(24)(25)(26) by immunofluorescence. High positive rates, varying from 70 to 80% were observed when other diagnostic methods, such as culture and serology, were associated to immunofluorescence (20,21) .…”

Section: Discussionsupporting

confidence: 88%

Respiratory syncytial virus infection in children under one year of age hospitalized for acute respiratory diseases in Pelotas, RS

et al. 2003

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Section: Discussionsupporting

confidence: 88%

Respiratory syncytial virus infection in children under one year of age hospitalized for acute respiratory diseases in Pelotas, RS

et al. 2003

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“…[28][29][30] Perhaps the fact that more people remain indoors during this period, resulting in overcrowding, could explain this. 25 The peak season was different in Hong Kong 27 and Bangladesh, 24 possibly because of a different rainy season. The total duration of hospitalization due to ALRTI was 36,774 days.…”

Section: Discussionmentioning

confidence: 99%

Acute Respiratory Tract Infections: Epidemiological Data, Guided Case Management and Outcome in a Pediatric Hospital in Riyadh

Ghazal¹,

Howasi²,

Chowdhury³

1998

Ann Saudi Med

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“…This percentage was similar to that seen in Hong Kong, which was 6.6%. 14 In 70% of our patients admitted with bronchiolitis, RSV was found to be the etiologic agent. Out of all those with the admission diagnosis of bronchiolitis, we selected a group of patients according to predetermined criteria for virological studies during the peak bronchiolitis period.…”

Section: Discussionmentioning

confidence: 78%

Respiratory Syncytial Virus in Saudi Patients Admitted to Hospital with Bronchiolitis: Use of Direct Fluorescent Antibody Tests as a Rapid Diagnostic Tool

Chowdhury

Al-Howasi

Ramia³

et al. 1996

Ann Saudi Med

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: [90][91][92] Bronchiolitis is a major cause of morbidity and occasional mortality in young infants and children all over the world. Respiratory syncytial virus (RSV) is the major etiologic agent responsible for this condition. The illness is more severe in patients with bronchopulmonary dysplasia and congenital heart diseases, especially with pulmonary hypertension and preterm infants. Early treatment with ribavirin is recommended in infants with underlying immunodeficiency and complicated heart disease (including pulmonary hypertension) and should be considered in infants who are severely ill with PaCO 2 less than 65 mmHg (American Academy of Pediatrics).1 Recently, RSVspecific immunoglobulin (RSVIG) was found to be effective in ameliorating RSV infections when used prophylactically in patients with bronchopulmonary dysplasia (BPD), congenital heart disease and prematurity. 2,3 RSVIG may also have therapeutic effectiveness in those high-risk infants.1 Early diagnosis is also required to institute infection control measures. It is thus desirable that early and accurate diagnosis of RSV infection be made if these therapeutic modalities are to be employed early to obtain maximum benefit. In this study, we compared the efficacy of direct fluorescent antibody (DFA) technique as a rapid and reliable diagnostic tool to isolation of the virus in cell culture. We also describe the magnitude of bronchiolitis as experienced in a pediatric hospital in Saudi Arabia, as well as the significance of RSV as its main etiologic agent compared to the Western experiences. Patients and MethodsDuring the year 1413H, 485 patients were admitted to Suleimania Children's Hospital in Riyadh City with the clinical diagnosis of bronchiolitis. During the study period of the winter season of the same year, from 19.4.1413H to 8.8.1413H, which is considered the peak season for RSV infection in this part of the world, 4 all patients with bronchiolitis were screened for eligibility to be enrolled in the study, as per the following criteria: 1) age below two years; 2) presence of wheezing-audible and/or on auscultation; 3) no previous history of wheezing; 4) no chronic pulmonary disease such as cystic fibrosis or BPD; 5) no congenital heart disease; 6) no significant radiological consolidation. The diagnosis was made on the history of cough and/or wheezes, tachypnea, retractions, and wheezing and crackles on auscultation. As the diagnosis of bronchiolitis is essentially clinical, based on history and clinical findings, we chose the above diagnostic criteria. Hyperinflation on the chest film is also an important pointer to the diagnosis, but it was not done in all patients. The eligibility criteria were devised to exclude, as much as possible, other causes of wheezing in infancy to avoid the error of overdiagnosing bronchiolitis. Patients with radiologic consolidation were excluded because young children with pneumonia may also wheeze, thus questioning the diagnosis of bronchiolitis in those patients. The hospital scientific committee approved th...

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Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants

Cited by 66 publications

References 19 publications

Respiratory syncytial virus infection in children under one year of age hospitalized for acute respiratory diseases in Pelotas, RS

Respiratory syncytial virus infection in children under one year of age hospitalized for acute respiratory diseases in Pelotas, RS

Acute Respiratory Tract Infections: Epidemiological Data, Guided Case Management and Outcome in a Pediatric Hospital in Riyadh

Respiratory Syncytial Virus in Saudi Patients Admitted to Hospital with Bronchiolitis: Use of Direct Fluorescent Antibody Tests as a Rapid Diagnostic Tool

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