Epidemiologie von Krebserkrankungen im Kindes- und Jugendalter

Wellbrock, Maike; Spix, Claudia; Grabow, Desiree; Erdmann, Friederike

doi:10.1007/s00761-021-00941-8

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…In addition to the risk of death, intensive treatment at a young age and the patients' long remaining life spans put them at risk of somatic late effects as well as adverse psychosocial and socioeconomic consequences later in life. [6][7][8][9] Childhood cancer represents a heterogeneous group of diseases, including malignancies and nonmalignant tumours in the central nervous system (CNS), showing a wide variety of patterns regarding incidence, 5,10,11 aetiology, [12][13][14][15] treatment 8,16,17 and clinical outcomes. 5,[18][19][20][21] In HICs, leukaemias, tumours of the CNS and lymphomas are the most frequent cancers in children.…”

Section: Introductionmentioning

confidence: 99%

“…5,[18][19][20][21] In HICs, leukaemias, tumours of the CNS and lymphomas are the most frequent cancers in children. 1,5,11 The aetiology of most childhood cancers remains poorly understood, with established risk factors explaining only about 10% of all incident cases. 13,14 Consequently, approaches for primary preventive measures are lacking, rendering treatment effectiveness to improve survival especially important in reducing the overall burden of disease.…”

Section: Introductionmentioning

confidence: 99%

“…Childhood cancer represents a heterogeneous group of diseases, including malignancies and nonmalignant tumours in the central nervous system (CNS), showing a wide variety of patterns regarding incidence, 5,10,11 aetiology, 12‐15 treatment 8,16,17 and clinical outcomes 5,18‐21 . In HICs, leukaemias, tumours of the CNS and lymphomas are the most frequent cancers in children 1,5,11 …”

Section: Introductionmentioning

confidence: 99%

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Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register‐study based on data from the German Childhood Cancer Registry

Wellbrock

Spix

Ronckers

et al. 2023

Intl Journal of Cancer

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Childhood cancer is the leading disease-related cause of death among under 15 year olds in Europe. Since primary preventive measures are lacking, improving survival probabilities and long-term well-being remain primary goals. With this report, we provide the first long-term assessment and interpretation of patterns in childhood cancer survival in Germany, covering a period of 30 years. Using data from the German Childhood Cancer Registry, we assessed temporal patterns of cancer survival among children (0-14 years) diagnosed in Germany from 1991 to 2016, by cancer type, age at diagnosis and sex. We calculated overall survival (OS) and average annual percentage changes of the respective 5-year OS estimates. OS improved across all cancer types, age groups as well as for boys and girls over time. Five-year OS for all childhood cancers combined increased from 77.8% in 1991-1995 to 86.5% in 2011-2016, with stronger improvements during the early 1990s. The most pronounced survival improvement was seen for acute myeloid leukaemia, at 2% annually and 5-year OS recently reaching 81.5%. Survival improvements for some diagnoses such as neuroblastoma, renal tumours and bone tumours have flattened out. Tremendous enhancements in diagnostics, treatment and supportive care have affected average survival

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register‐study based on data from the German Childhood Cancer Registry

Wellbrock

Spix

Ronckers

et al. 2023

Intl Journal of Cancer

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Impact of virtual reality on peri-interventional pain, anxiety and distress in a pediatric oncology outpatient clinic: a randomized controlled trial

Reitze,

Voigt,

Klawonn

et al. 2024

BMC Pediatr

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Purpose Pain and anxiety-inducing interventions have a major impact on pediatric patients. Pain reduction by virtual reality (VR) during port and vein punctures is well studied. This study investigates peri-interventional reduction of pain, anxiety and distress using VR compared to the standard of care (SOC) in a pediatric oncology outpatient clinic. Methods In a randomized, controlled cross-over design, patients aged 6–18 years experience potentially painful interventions accompanied by VR. Observational instruments include NRS, FPS-r, BAADS, mYPAS-SF, PedsQL and SSKJ3-8R. All patients undergo two observations: SOC (A) and VR (B) in a randomized order. In addition, parents and staff are interviewed. Specific conditions for VR in an outpatient clinic setting derived from interprofessional focus group discussion are being explored. Results Between July 2021 and December 2022 57 eligible patients were included and randomized to the orders A/B (n = 28) and B/A (n = 29). Thirty-eight patients completed both observations. Characteristics in both groups did not differ significantly. More than half of the patients had no previous experience with VR, 5% decided to discontinue VR prematurely. Peri-interventional pain, anxiety and distress were significantly reduced by VR compared with SOC. 71% of patients and 76% of parents perceived punctures with VR to be more relaxed than previous ones. 95% of patients perceived fun with VR goggles. Detailed questionnaires on individual stress and anxiety were returned from 26 of 38 patients. Focus group discussion with staff yielded evidence for successful implementation of VR in an outpatient clinic. Conclusions The present study shows that VR can be used for peri-interventional reduction of pain, anxiety, and distress in the special environment of a pediatric outpatient clinic. Specific conditions must be met for successful implementation. Further studies are needed to identify particularly susceptible patients and to illuminate alternatives for distraction that are feasible to implement with limited resources. Trial registration number (ClinicalTrials.gov ID): NCT06235723; 01/02/2024; retrospectively registered. This study adheres to the standard checklist of CONSORT guidelines.

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Epidemiologie von Krebserkrankungen im Kindes- und Jugendalter

Cited by 2 publications

References 26 publications

Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register‐study based on data from the German Childhood Cancer Registry

Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register‐study based on data from the German Childhood Cancer Registry

Impact of virtual reality on peri-interventional pain, anxiety and distress in a pediatric oncology outpatient clinic: a randomized controlled trial

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