Epidemiologie und Therapie der Lyme-Arthritis und anderer Manifestationen der Lyme-Borreliose in Deutschland

Priem, Susanne; Munkelt, Katja; Franz, Juliane K.; Schneider, Ulrike; Werner, T.; Burmester, G.-R.; Krause, Andreas

doi:10.1007/s00393-003-0481-3

Cited by 14 publications

(12 citation statements)

References 17 publications

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“…Moreover, infant BALB mice or C.B.-17 mice with severe combined immunodeficiency (BALB-congenic) are similar to C3H mice and develop severe pathology [77,81,82], suggesting that susceptibility to disease has an immunological component. Also, around 60% of human patients in North America [52] and up to 24.5% in Europe [83] develop migratory joint pain that results in chronic polysynovitis, characterized by synovial lesions similar to other types of chronic inflammatory arthritis such as rheumatoid arthritis [53]. Yet, only a relatively small percentage of LD patients develop chronic objective arthritis, which suggests that there could be host-related factors that determine susceptibility to the natural course of disease.…”

Section: Genetic Susceptibility To Disease and Autoimmunitymentioning

confidence: 99%

Lyme Disease Frontiers: Reconciling Borrelia Biology and Clinical Conundrums

Bamm

Mainprize

et al. 2019

Pathogens

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Lyme disease is a complex tick-borne zoonosis that poses an escalating public health threat in several parts of the world, despite sophisticated healthcare infrastructure and decades of effort to address the problem. Concepts like the true burden of the illness, from incidence rates to longstanding consequences of infection, and optimal case management, also remain shrouded in controversy. At the heart of this multidisciplinary issue are the causative spirochetal pathogens belonging to the Borrelia Lyme complex. Their unusual physiology and versatile lifestyle have challenged microbiologists, and may also hold the key to unlocking mysteries of the disease. The goal of this review is therefore to integrate established and emerging concepts of Borrelia biology and pathogenesis, and position them in the broader context of biomedical research and clinical practice. We begin by considering the conventions around diagnosing and characterizing Lyme disease that have served as a conceptual framework for the discipline. We then explore virulence from the perspective of both host (genetic and environmental predispositions) and pathogen (serotypes, dissemination, and immune modulation), as well as considering antimicrobial strategies (lab methodology, resistance, persistence, and clinical application), and borrelial adaptations of hypothesized medical significance (phenotypic plasticity or pleomorphy).

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Section: Genetic Susceptibility To Disease and Autoimmunitymentioning

confidence: 99%

Lyme Disease Frontiers: Reconciling Borrelia Biology and Clinical Conundrums

Bamm

Mainprize

et al. 2019

Pathogens

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“…The results presented are in line with existing publications. This can be seen, for example, in the quality of life [5,[21][22][23] and in the varied information collected related to the diagnostic process [3,6,24]. In summary, the present research was able to establish significant associations between the investigated symptoms and chronic Lyme disease.…”

Section: Discussionmentioning

confidence: 54%

Neuropsychiatric and Psychological Symptoms in Patients with Lyme Disease: A Study of 252 Patients

2021

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This study examined the relationship between neuropsychiatric and psychological symptoms in patients with Lyme borreliosis. We collected data from an experimental group of 252 Lyme disease patients and a control group of 267 healthy individuals. The quality of life and sleep, attention and memory performance were assessed in both groups. Additionally, we investigated depressive symptoms in patients with Lyme disease to examine whether the duration of the disease had an influence on the severity of symptoms shown. Furthermore, various data on the diagnostics and treatment carried out in the patient group were recorded. On average, patients visited almost eight physicians to obtain a diagnosis, and eight years passed between the tick bite and diagnosis (SD ± 7.8); less than half of the sample (46%) received their diagnosis within the first five years after the development of symptoms. It became clear that Lyme disease is often diagnosed very late. It appears that people suffering from Lyme disease have significantly lower quality of life and sleep and show cognitive impairments when it comes to attention and memory. This study shows that 3.1% of Lyme patients were satisfied with their lives and that 37% scored in the lower third of the quality-of-life scale. It was also shown that Lyme patients tend to have depressive symptoms.

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“…Około 10% chorych wykazuje przetrwałe, antybiotykooporne zapalenie stawów, z objawami utrzymującymi się mimo standardowej, a nawet wielokrotnie powtarzanej antybiotykoterapii. Rozróżnienie pomiędzy tymi sytuacjami umożliwia ocena obecności DNA B. burgdorferi w płynie stawowym lub synowium (1,6,13,14) . W związku z tym, że występowanie B. burgdorferi sensu stricto, mającej powinowactwo do stawów, w Europie jest rzadsze, zapalenie stawów w przebiegu boreliozy rozpoznaje się rzadziej niż w USA.…”

Section: Zapalenie Stawówunclassified

Lyme disease – principles of diagnosis and treatment

Pancewicz¹

2014

Pediatr Med Rodz

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Epidemiologie und Therapie der Lyme-Arthritis und anderer Manifestationen der Lyme-Borreliose in Deutschland

Cited by 14 publications

References 17 publications

Lyme Disease Frontiers: Reconciling Borrelia Biology and Clinical Conundrums

Lyme Disease Frontiers: Reconciling Borrelia Biology and Clinical Conundrums

Neuropsychiatric and Psychological Symptoms in Patients with Lyme Disease: A Study of 252 Patients

Lyme disease – principles of diagnosis and treatment

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