Épidémiologie des cancers bronchopulmonaires primitifs des non-fumeurs au Sénégal

Thiam, K.; Touré, N.O.; Ndiaye, Emilia; Baddredine, H.; Ndiaye, Moustapha; Diop, M; Niang, A.; Ba, Oumar; Kane, Y. Dia; Diatta, A.; Cissé, M.F.; Mbaye, F.B.R.; Wayzani, M.; Niang, S.; Sagne, J.M.A.N.; Dia, S.; Ndao, M.; Ka, W.

doi:10.1016/j.rmr.2017.11.012

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…Age at diagnosis of never smokers, in our study, was relatively younger compared with other research [19]- [22]. Several studies have shown that never smokers comparing to smokers were diagnosed at an early age [9], [18], [21]. Some authors explained this by the susceptibility of non-smokers to environmental pollutants, especially passive smoking [17].…”

Section: Resultscontrasting

confidence: 45%

“…Studies around the world have reported heterogeneous proportions of never smokers among patients with lung cancer, ranging from about 10% in males in the western countries to nearly 40% in Asian females [16], [17]. A study performed in Senegal found a proportion of 33.3% of never smokers [18]. Another Brazilian study showed that 19.65% of lung cancer cases were never smokers [19].…”

Section: Resultsmentioning

confidence: 99%

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Never smokers with lung cancer in Morocco: epidemiology and gender differences

Erefai

Soulaymani

Mokhtari

et al. 2022

IJPHS

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Even through smoking is a definite risk factor for lung cancer, it is possible for people who have never smoked to suffer lung cancer. This research aimed to describe the epidemiology of lung cancer in never smokers in Morocco. Also, an assessment of differences between men and women never smokers was performed. The researchers analyzed retrospectively all patients diagnosed with lung cancer between 2014 and 2017. The results showed that of 606 patients, 157 (25.9%) were never smokers. Of these, 79 patients (50.32%) were women. Women were more likely to be younger (p=0.034), had adenocarcinoma (p=0.046), and being in advanced stage of the disease (p=0.032). Men were more exposed to professional carcinogens (p<0.001). Tuberculosis was the most frequent previous lung disease in never smokers, but no difference was noted between men and women. Performance status and comorbidities did not vary by gender. Never smokers in Morocco represent a significant proportion of lung cancer. Evident epidemiologic differences are found between men and women never smokers, notably, age, histological type and risk factor exposure.

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Section: Resultscontrasting

confidence: 45%

Section: Resultsmentioning

confidence: 99%

Never smokers with lung cancer in Morocco: epidemiology and gender differences

Erefai

Soulaymani

Mokhtari

et al. 2022

IJPHS

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“…The main cause of lung cancer is the exposure of the body to harmful, carcinogenic chemical substances [5][6][7]. It is believed that the most common and important risk factor for all histological types of lung cancer, responsible for the development of about 85% of all cases, is smoking [8][9][10][11][12]. The possibility of cancer appearance in smokers increases 20-fold in comparison with non-smokers [9,13].…”

Section: Introduction-lung Cancer Classificationmentioning

confidence: 99%

“…It is believed that the most common and important risk factor for all histological types of lung cancer, responsible for the development of about 85% of all cases, is smoking [8][9][10][11][12]. The possibility of cancer appearance in smokers increases 20-fold in comparison with non-smokers [9,13]. Furthermore, it was found that both the duration of the smoking habit and the number of daily cigarettes have a directly proportional effect on the appearance of lung cancer [1,4,[13][14][15][16][17].…”

Section: Introduction-lung Cancer Classificationmentioning

confidence: 99%

Role of SOX Protein Groups F and H in Lung Cancer Progression

Olbromski¹,

Podhorska‐Okołów

Dzięgiel

2020

Cancers

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The SOX family proteins are proved to play a crucial role in the development of the lymphatic ducts and the cardiovascular system. Moreover, an increased expression level of the SOX18 protein has been found in many malignances, such as melanoma, stomach, pancreatic breast and lung cancers. Another SOX family protein, the SOX30 transcription factor, is responsible for the development of male germ cells. Additionally, recent studies have shown its proapoptotic character in non-small cell lung cancer cells. Our preliminary studies showed a disparity in the amount of mRNA of the SOX18 gene relative to the amount of protein. This is why our attention has been focused on microRNA (miRNA) molecules, which could regulate the SOX18 gene transcript level. Recent data point to the fact that, in practically all types of cancer, hundreds of genes exhibit an abnormal methylation, covering around 5–10% of the thousands of CpG islands present in the promoter sequences, which in normal cells should not be methylated from the moment the embryo finishes its development. It has been demonstrated that in non-small-cell lung cancer (NSCLC) cases there is a large heterogeneity of the methylation process. The role of the SOX18 and SOX30 expression in non-small-cell lung cancers (NSCLCs) is not yet fully understood. However, if we take into account previous reports, these proteins may be important factors in the development and progression of these malignancies.

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Épidémiologie des cancers bronchopulmonaires primitifs des non-fumeurs au Sénégal

Cited by 2 publications

References 13 publications

Never smokers with lung cancer in Morocco: epidemiology and gender differences

Never smokers with lung cancer in Morocco: epidemiology and gender differences

Role of SOX Protein Groups F and H in Lung Cancer Progression

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