Épidémiologie de l'asthme grave

Charpin, D.; Bouaziz, N.

doi:10.1016/s0335-7457(97)80162-1

Cited by 2 publications

(2 citation statements)

References 70 publications

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“…These results are also in agreement with those of Agnero [13] by evaluating the antitussive activity of chrysophyllum welwitschiiengl.in rats and comparing it to that of dextromethorphan. Also, just like asthma, cough is caused by a stimulus and this stimulus would be inflammatory (allergens), mechanical, chemical (inhalation of gas, smoke) or thermal [37]. It is therefore probable that the aqueous extract of Asthpadose reduces the number of coughs by inhibiting either the inflammatory process or the nerve impulse responsible for triggering the cough [38].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

Léonce,

Bognan,

Raoul

et al. 2024

Asian J. Res. Biochem.

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Introduction: The aim of this study is to contribute to the valorisation of an anti- asthmatic phytomedicine (Asthpadose) traditionally used in Côte d'Ivoire. Aims: Evalute antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was. Methodology: The antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was evaluated by the determining of its anti-inflammatory activity using the carrageenan oedema induction method. This anti-asthmatic activity was also evaluated by its antitussive action on the frequency of cough induced in rats exposed to liquid ammonia. Results: The results revealed that EAA showed a very significant strong anti- inflammatory activity with an oedema inhibition rate ranging from 34.29% to 70.9 5%. This activity was much better than that of diclofenac sodium (a reference molecule against inflammation) with an oedema inhibition rate ranging from 12.24% to 58.39%. As for its antitussive activity, the results also showed good antitussive activity of the extract. EAA presented a cough inhibition rate of 74.22% compared to 58.76% for dextrometaphan which is also a reference molecule against cough. Conclusion: This observed activity could therefore justify the use of Asthpadose in the treatment of asthma which is a disease manifested by inflammation and cough. In view of the very promising results of this study, it would therefore be necessary to continue studies on this phytomedicine to understand its mechanism of action on asthma.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

Léonce,

Bognan,

Raoul

et al. 2024

Asian J. Res. Biochem.

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“…L'asthme et la toux sont souvent associés [9]. On sait que la toux est provoquée par un stimulus [5]. Ce stimulus peut être de nature inflammatoire (allergènes), mécanique, chimique (inhalation de gaz, de fumée) ou thermique [7].…”

Section: Discussionunclassified

Évaluation de l’activité antiasthmatique et antitussive de Combretum molle, plante médicinale de la pharmacopée ivoirienne

et al. 2008

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Cette étude a été consacrée à l'analyse des effets inhibiteurs de l'extrait aqueux de Combretum molle sur les variations des amplitudes respiratoires et la toux. Nous avons observé que l'injection de cet extrait aux doses testées (3,33 mg/kg, 7,14 mg/kg) ne produit aucun effet sur la respiration normale du lapin. Par ailleurs, l'injection de 0,2 ml d'acétylcholine (714.10 -3 mg/kg) a induit un pourcentage estimé à -100 %. Toutefois, l'injection combinée de l'acétyl-choline (0,2 ml, 714.10 -3 mg/kg) et de doses croissantes d'extrait aqueux de Combretum molle (3,33 mg/kg, 3,5 mg/kg, 7,14mg/kg) a induit une réduction du pourcentage de variation des amplitudes respiratoires de -100 % à -20 ± 0,5 %. En outre, nous avons testé les effets de l'extrait aqueux sur la toux. Les cobayes non traités par cet extrait de Combretum molle donnent en moyenne 10,25 ± 0,95 toux sur dix minutes. Ce lot constitue le témoin. En revanche, le prétraitement des cobayes par 3 mg/kg d'extrait total a provoqué 8,25 ± 0,45 toux pendant dix minutes. Alors qu'avec 30 mg/kg la réduction est passée de 10,25 ± 0,95 à 4,5 ± 0,25 toux. Ces résultats nous ont permis de conclure que l'extrait aqueux présente des effets inhibiteurs sur la toux et les bronchoconstrictions induites par l'acétylcholine.Abstract: In this work, we studied the inhibitory effects of Combretum molle extract on respiratory disturbances and coughs. Injection of 3.33 mg/kg and 7.14 mg/kg of Combretum molle had no effect on a rabbit's breathing. Injection of acetylcholine (0.2 ml; 714.10 -3 mg/kg) induced a percentage estimated at -100%. But a combined injection of acetylcholine and increasing doses of Combretum molle reduced this percentage from -100% to -20 ± 0.5%. We also studied the inhibitory effects of the crude extract on coughs. Guinea pigs which were not treated produced 10.25 ± 0.95 in 10 minutes. But treating the guinea-pigs with 3 mg/kg of crude extract resulted in 8.25 ± 0.45 coughs for 10 min. With 30 mg/kg, however, coughing was reduced to 4.5 ± 0.25. We could therefore conclude that the extract presents some inhibitory effects on coughing and bronchial contraction induced by acetylcholine.

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Épidémiologie de l'asthme grave

Cited by 2 publications

References 70 publications

Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

Évaluation de l’activité antiasthmatique et antitussive de Combretum molle, plante médicinale de la pharmacopée ivoirienne

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