Épidémiologie clinique et parasitologique de la leishmaniose cutanée dans cinq villages du Pays Dogon, Mali

Koné, Abdoulaye K.; Delaunay, Pascal; Djimdé, Abdoulaye; Thera, Mahamadou A.; Giudice, P. Del; Coulibaly, Drissa; Traore, Karim; Goïta, Siaka; Abathina, Amadou; Izri, Arezki; Marty, Pierre; Doumbo, Ogobara K.

doi:10.1007/s13149-011-0194-9

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…Eighteen studies report cases seen in specialized dermatology services. The proportion of CL cases among patients seen in those dermatology clinics is consistently less than 5% [ 59 , 69 , 94 ]. In the context of an outbreak, CL patients who seek care in specialized services represent only the tip of an iceberg, as shown in Burkina Faso (further described below).…”

Section: Resultsmentioning

confidence: 99%

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review

et al. 2018

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IntroductionCutaneous leishmaniasis (CL) is the most frequent form of leishmaniasis, with 0.7 to 1.2 million cases per year globally. However, the burden of CL is poorly documented in some regions. We carried out this review to synthesize knowledge on the epidemiological burden of CL in sub-Saharan Africa.MethodsWe systematically searched PubMed, CABI Global health, Africa Index Medicus databases for publications on CL and its burden. There were no restrictions on language/publication date. Case series with less than ten patients, species identification studies, reviews, non-human, and non-CL focused studies were excluded. Findings were extracted and described. The review was conducted following PRISMA guidelines; the protocol was registered in PROSPERO (42016036272).ResultsFrom 289 identified records, 54 met eligibility criteria and were included in the synthesis. CL was reported from 13 of the 48 sub-Saharan African countries (3 eastern, nine western and one from southern Africa). More than half of the records (30/54; 56%) were from western Africa, notably Senegal, Burkina Faso and Mali. All studies were observational: 29 were descriptive case series (total 13,257 cases), and 24 followed a cross-sectional design. The majority (78%) of the studies were carried out before the year 2000. Forty-two studies mentioned the parasite species, but was either assumed or attributed on the historical account. Regional differences in clinical manifestations were reported. We found high variability across methodologies, leading to difficulties to compare or combine data. The prevalence in hospital settings among suspected cases ranged between 0.1 and 14.2%. At the community level, CL prevalence varied widely between studies. Outbreaks of thousands of cases occurred in Ethiopia, Ghana, and Sudan. Polymorphism of CL in HIV-infected people is a concern. Key information gaps in CL burden here include population-based CL prevalence/incidence, risk factors, and its socio-economic burden.ConclusionThe evidence on CL epidemiology in sub-Saharan Africa is scanty. The CL frequency and severity are poorly identified. There is a need for population-based studies to define the CL burden better. Endemic countries should consider research and action to improve burden estimation and essential control measures including diagnosis and treatment capacity.

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Section: Resultsmentioning

confidence: 99%

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review

et al. 2018

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“…Epidemiological studies suggest that CL is widely distributed throughout Mali [ 38 ]. In fact, the prevalence of L. major infection is as high as 45% within individuals residing in central Mali (Kemena, 45% LST-positive and Sougoula 20% LST-positive) [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali

Sangare¹,

Coulibaly²,

Coulibaly³

et al. 2018

Parasites Vectors

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BackgroundFilariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Mansonella perstans) and Leishmania major parasites in two ecologically distinct areas of Mali, the Kolokani district (villages of Tieneguebougou and Bougoudiana) in North Sudan Savanna area, and the district of Kolondieba (village of Boundioba) in the South Sudan Savanna area.MethodsThe prevalence of co-infection (filarial and Leishmania) was measured based on (i) Mansonella perstans microfilaremia count and/or filariasis immunochromatographic test (ICT) for Wuchereria bancrofti-specific circulating antigen, and (ii) the prevalence of delayed type hypersensitivity (DTH) responses to Leishmania measured by leishmanin skin test (LST).ResultsIn this study, a total of 930 volunteers between the age of 18 and 65 were included from the two endemic areas of Kolokani and Kolondieba. In general, in both areas, filarial infection was more prevalent than Leishmania infection with an overall prevalence of 15.27% (142/930) including 8.7% (81/930) for Mansonella perstans and 8% (74/930) for Wuchereria bancrofti-specific circulating antigen. The prevalence of Leishmania major infection was 7.7% (72/930) and was significantly higher in Tieneguebougou and Bougoudiana (15.05%; 64/425) than in Boundioba (2.04%; 8/505) (χ2 = 58.66, P < 0.0001). Among the filarial infected population, nearly 10% (14/142) were also positive for Leishmania with an overall prevalence of co-infection of 1.50% (14/930) varying from 2.82% (12/425) in Tieneguebougou and Bougoudiana to 0.39% (2/505) in Boundioba (P = 0.0048).ConclusionThis study established the existence of co-endemicity of filarial and Leishmania infections in specific regions of Mali. Since both filarial and Leishmania infections are vector-borne with mosquitoes and sand flies as respective vectors, an integrated vector control approach should be considered in co-endemic areas. The effect of potential interaction between filarial and Leishmania parasites on the disease outcomes may be further studied.

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“…Aussi, pour écarter donc toute hypothèse de l'implication du rongeur Procavia capensis dans la transmission de L. major à Bamako, il convient de procéder à un diagnostic différentiel précis entre les deux espèces de Leishmanie, L. major et L. tropica responsables de la LC, aussi bien chez les sujets diagnostiqués à Bamako que chez les phlébotomes collectés. Dans la pratique, le diagnostic différentiel entre la LC à L. major et la LC à L. tropica peut poser un problème dans les zones où coexistent les deux espèces, jusqu'ici la LC à L. major est la seule forme clinique décrite au Mali (Imperato & Diakite 1969;Keita et al 2003;Kone et al 2012) et L. major est la seule espèce identifiée chez les cas humains diagnostiqués à Bamako (Paz et al 2013) et chez les phlébotomes collectés. La recherche de l'ADN de Leishmania chez Phlebotomus sergenti dans le pays dogon n'a été concluante (Berdjane-Brouk et al 2012) La faune phlébotomienne capturée était plus variée comparée à celle observée par Ranque et al (1975).…”

Section: Caractéristiques Des Zones Potentielles De Développement Desunclassified

“…L'intégration des données spatiales concernant le(s) réservoir(s) rongeur(s), le(s) vecteur(s) phlébotome(s) et l'occupation humaine basée sur les caractéristiques du paysage et de la topographie dérivées des images satellitaires permettrait de mieux cartographier le risque de transmission de la leishmaniose et de cibler ainsi les méthodes de prévention et de contrôle de la maladie à l'échelle de la ville de Bamako. L'identification d'un foyer de transmission à travers une enquête centrée sur un cas clinique suspect et l'investigation entomologique dans l'habitat et les alentours du cas pourraient davantage conduire à la confirmation d'une transmission locale (Kone et al 2012).…”

Section: Caractéristiques Des Zones Potentielles De Développement Desunclassified

“…L'incidence annuelle de la LC dans le monde est estimée entre 0,7 à 1,2 millions de cas. En Afrique de l'Ouest, l'épidémiologie de cette protozoose est caractérisée par la survenue d'épidémies en milieux urbain et rural (Traore et al 2001;Kweku et al 2011;Kone et al 2012) à cause probablement de l'urbanisation anarchique, des changements environnementaux et du comportement de l'homme (Hamida 2012). Au Mali où la maladie est principalement due à L. major (Paz et al 2013), une étude a montré que l'incidence varie de 290 à 580 cas par an (Alvar et al 2012).…”

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Distribution spatio-temporelle de la faune de phlébotomes en zones urbaine et périurbaine de Bamako, Mali

Koné

Diarra

Coulibaly

et al. 2016

Annales de la Société entomologique de France (N.S.)

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Épidémiologie clinique et parasitologique de la leishmaniose cutanée dans cinq villages du Pays Dogon, Mali

Cited by 6 publications

References 14 publications

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review

A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali

Distribution spatio-temporelle de la faune de phlébotomes en zones urbaine et périurbaine de Bamako, Mali

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