Epidemiological trends of oropharyngeal and oral cavity squamous cell carcinomas in Northern New England, 2000–2013

Owosho, Adepitan A.; Vélez, Miguel González; Tyburski, Alexander; Hofheins, John; Wiley, Rashidah; Stansbury, Tessie; Gbadamosi, Semiu O; Ryder, Jon S

doi:10.1007/s10552-019-1136-2

Cited by 12 publications

(21 citation statements)

References 37 publications

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“…However, the incidence of OPSCC in Eastern Denmark has continued to rise with 62% of cases including HPV+, implying that the effects still remain to take effect and that there still exists a high HPV prevalence . We continue to recommend use of vaccination against HPV as well as public health efforts toward patient sexual education, smoking cessation, and alcohol abuse control to decrease the risk of OPSCC …”

Section: Discussionmentioning

confidence: 99%

Childhood tonsillectomy alters the primary distribution of HPV‐related oropharyngeal squamous cell carcinoma

Altenhofen

DeWees

Ahn

et al. 2020

Laryngoscope Investig Oto

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Objectives: We investigated how tonsillectomy during childhood may influence the distribution of human papillomavirus (HPV) positive cancer of the tonsils in adult life using p16 as a surrogate marker for HPV infection.Study Design: Retrospective observational study.Methods: A total of 280 patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) and known p16 status were eligible for this study. Each participant was called to obtain the childhood tonsillectomy history. Respondents were subgrouped by p16 status and the primary tumor location. Patient demographic and clinical information was analyzed for association with Fisher's exact and Wilcoxon rank sum tests.Location of tumor was modeled using univariate (UVA) and multivariate (MVA) logistic regression with associated odds ratios (OR) and 95% confidence intervals.Results: Of the 280 patients, 115 (41%) were respondents: 104 (90.4%) were p16 positive and 11 (9.6%) were p16 negative. For p16 positive patients, we observed a majority (93%) of intact tonsils in those with tonsil cancer, compared to 45% of intact tonsils in patients with p16 positive cancer elsewhere in the oropharynx (P < .001). MVA logistic regression showed that female gender (OR = 4.16, P = .0675), prior smoking history (OR = 2.6, P = .0367), and intact tonsils (OR = 15.2, P < .0001) were associated with tonsillar OPSCC. Conclusion:We found that patients with p16 positive OPSCC at a non-tonsil site were much more likely to have had prior tonsillectomy vs those with p16 positive OPSCC arising within the tonsil. Nevertheless, we do not advocate tonsillectomies as a public health policy to reduce HPV-related OPSCC. Level of Evidence: 6 K E Y W O R D S human papillomavirus (HPV), p16, tonsil cancer, tonsillectomy Brannon Altenhofen and Todd A. DeWees contributed equally to this study.

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Section: Discussionmentioning

confidence: 99%

Childhood tonsillectomy alters the primary distribution of HPV‐related oropharyngeal squamous cell carcinoma

Altenhofen

DeWees

Ahn

et al. 2020

Laryngoscope Investig Oto

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“…When oral cancer metastasizes, it is usually to the lymph nodes in the cervix. It can even metastasize to other parts of the body [65][66][67].…”

Section: Discussionmentioning

confidence: 99%

HPV induced tongue cancer in pregnancy: Diagnosis and the role of vaccination in management

Tsikouras¹,

Bothou²,

Paraskevopoulos³

et al. 2020

Clin Obstet Gynecol Reprod Med

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Oral cancer is frequently a squamous cell carcinoma. In Western countries it is more commonly found on the tongue and consists one of the most common malignancies in the oral mucosa. The exact causes of squamous cell carcinoma are not known. There are many risk factors such as chemical, biological, natural and other related to culture, habits, customs and traditions, religion and environmental influences at the national level and differ in different nations. Biological agents are viruses (such as the herpes simplex virus, HPV, HIV) and mycoses. Human papillomavirus (HPV), especially HPV subtype 16, is on the rise in young people with oral cancer who are not smokers. Epidemiological studies throughout world with the help of molecular techniques undoubtedly show the crucial importance of human papillomavirus (HPV) in growth squamous cell carcinoma. The sensitive anatomical unit of the tongue in cases of malignancy in pregnant women creates significant bioethical concerns that must be addressed with delicacy, discernment and responsibility by the oncology medical team. The contribution of the 9 valent vaccination, which provides protection against this oncogenic subtype of HPV 16 associated with squamous cell carcinoma, is likely to be valuable to young women and men, and may be recommended after future studies during pregnancy.

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“…A prevalência de HPV mostra-se variável em diversos estudos e em diferentes regiões geográficas. Infecções da cavidade bucal por HPV são maiores entre os indivíduos do sexo masculino, de meia-idade e com baixas condições socioeconômicas 18-11-19 , enfatizando-se que tal prevalência varia amplamente de acordo com fatores demográficos, influenciados pelas diferenças culturais [11][12][13][14][15][16][17][18][19] .…”

Section: Epidemiologiaunclassified

“…Entretanto, a realização de quimioterapia e radioterapia ocasiona graves efeitos adversos para os pacientes por possuírem elevadas taxas de toxicidade 29 . No entanto, alguns estudos indicam que pacientes acometidos concomitantemente por HPV e CEB apresentam melhores prognósticos, visto que esse vírus aumenta a sensibilidade do tumor ao tratamento radioterápico e quimioterápico, o que permite a redução da quantidade de sessões de tais tratamentos e, por conseguinte, proporciona uma maior sobrevida ao paciente [15][16][17][18][19][20][21][22][23] .…”

Section: Diagnóstico E Tratamentounclassified

“…Entretanto, barreiras sociais ainda precisam ser ultrapassadas para que esses profissionais consigam intervir de maneira eficaz em fatores determinantes para o processo de saúde-doença de seus pacientes [33][34][35] . Tais barreiras incluem, principalmente, a dificuldade da abordagem de assuntos relacionados a doenças sexualmente transmissíveis, como o HPV [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] .…”

Section: A Importância Da Atuação Do Cirurgião-dentistaunclassified

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Papilomavírus Humano enquanto fator etiológico do Carcinoma Epidermoide Bucal

Carvalho

Diniz²,

Araújo³

et al. 2020

CadUniFOA

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O Papilomavírus Humano (HPV) dos tipos 16 e 18 possui elevada capacidade carcinogênica, estando associado a diversos tumores malignos. Pesquisas indicam que o número de indivíduos que contraem HPV está aumentando de forma alarmante nos últimos anos, o que faz essa infecção apresentar um potencial endêmico. A partir disso, este estudo aborda alguns aspectos moleculares, histopatológicos, qualitativos e clínicos que envolvem o carcinoma epidermóide bucal (CEB) e sua relação com o HPV, tendo como objetivo primário elucidar os fatores que a literatura pesquisada aponta para demonstrar a relação existente entre ambos. Já como objetivo secundário, aponta-se a necessidade de enfatizar a importância da atuação do Cirurgião-Dentista na detecção precoce de tais patologias e na disseminação do conhecimento sobre tal temática. Para tal, foi realizada uma revisão de literatura nas bases de dados SCIELO, LILACS (BVS), PUBMED/MEDLINE, REVODONTO e Portal CAPES, buscando estudos que foram publicados de 2014 a setembro de 2019.

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Epidemiological trends of oropharyngeal and oral cavity squamous cell carcinomas in Northern New England, 2000–2013

Cited by 12 publications

References 37 publications

Childhood tonsillectomy alters the primary distribution of HPV‐related oropharyngeal squamous cell carcinoma

Childhood tonsillectomy alters the primary distribution of HPV‐related oropharyngeal squamous cell carcinoma

HPV induced tongue cancer in pregnancy: Diagnosis and the role of vaccination in management

Papilomavírus Humano enquanto fator etiológico do Carcinoma Epidermoide Bucal

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