Epidemiological trends of HIV‐1 infection in blood donors from Catalonia, Spain (2005‐2014)

Bes, Marta; Pirón, María; Casamitjana, Natàlia; Gregori, Josep; Esteban, Juan Ignacio; Ribera, Esteban; Quer, Josep; Puig, Lluís; Sauleda, Sílvia

doi:10.1111/trf.14195

Cited by 11 publications

(13 citation statements)

References 30 publications

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“…The rate of HIV-1 DR rate was 12.1% (43/356) is similar to that reported in the United States (13.0%) [30], Brazil (16.3%) [31] and some European countries such as Spain (14.0%) [32], but higher than Asia (4.6%) [33], The national (4.5%) [34], Chengdu (1.3%) [12], Guangxi (3.2%) [35] and five Blood center in 2007-2010 (4.4%) (Liuzhou, Kunming, Urumqi, Mianyang, Luoyang) [36], the difference may be caused by the continuous application of antiretroviral therapy (ART), so increasing the resistance of HIV-1. In this study, the HIV drug resistance rate in Chongqing, Urumqi and Mianyang was roughly the same as in previous studies.…”

Section: Discussionsupporting

confidence: 84%

The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014–2017

et al. 2020

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Human immunodeficiency virus-1 (HIV-1) exhibits high diversity and complexity in China, challenging the disease surveillance and antiretroviral therapy. Between July 1, 2014 and January 30, 2017, we investigated the profiles of HIV-1 infection stages, genotype distribution and drug resistance mutations (DRMs) using plasma samples from HIV Western blot (WB) confirmed blood donors from five Chinese blood centers (Chongqing, Guangxi, Luoyang, Mianyang, and Urumqi). HIV pol regions consisted of whole protease and partial reverse transcriptase were genotyped and analyzed for DRMs. Lag-Avidity testing was performed to identify the infection stages. Of the 356 HIV-1 WB positive samples tested by Lag-avidity assay, 19.1% (68/356) were recent infections. Genotyping on 356 amplified sequences presented the subtype distributions as following: CRF07_BC (65.7%), CRF08_BC (7.3%), CRF01_AE (19.1%), B (4.2%), CRF55_01B (3.1%), CRF59_01B (0.3%) and CRF68_01B (0.3%). No significant difference in genotype distribution was observed between recent and long-term infections. 48 DRMs were identified from 43 samples, indicating a drug resistance prevalence of 12.1% (43/356), which include seven protease inhibitors (PIs) accessory DRMs (Q58E, L23I and I84M), two PIs major DRMs (M46I, M46L), seven nucleoside RT inhibitors DRMs (D67N, K70Q, K219R and M184L), and 32 non-nucleoside RT inhibitors DRMs (K103N, V179E, K238N, V179D, E138G, G190E, A98G, Y188D and E138A). In addition, we had also identified CRFs from the 01B subtype including CRF55_01B (3.1%), CRF59_01B (0.3%) and CRF68_01B (0.3%). As an important part of the continuous monitoring of HIV-1 circulating strains among blood donors, our findings were expected to contribute to the comprehensive AIDS control and development of proper diagnostics for HIV-1 in China.

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Section: Discussionsupporting

confidence: 84%

The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014–2017

et al. 2020

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“…In Spain, donors are deferred for 12 months for sex with more than one concurrent partner, or sex with an occasional partner. A recent study from Catalonia, Spain, evaluating HIV infection rates in donors from 2005 to 2014, found an overall prevalence of HIV of 7·7 per 100 000 donations; rates in repeat donors were only slightly lower than in first‐time donors . Ten of the 214 infected donors (4·7%) had NAT only positive results, indicating recent infection.…”

Section: Current Deferral Policiesmentioning

confidence: 99%

“…Several countries, including Spain, Portugal and Italy, have implemented policies based on sexual behaviours considered to be at higher risk, regardless of whether the partner is same sex or opposite sex; these may be referred to as ‘gender‐neutral’ or ‘risk‐based’ deferral policies . Higher risk sexual activities may include sex with a new partner or with multiple partners, particularly if the partner's risk behaviour is unknown.…”

Section: Current Deferral Policiesmentioning

confidence: 99%

Donor deferral policies for men who have sex with men: past, present and future

et al. 2017

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We review the history and evolution of blood donor criteria for men who have sex with men (MSM). Deferral policies in many jurisdictions, including Australia, New Zealand, Canada, the United States, Brazil and many western European countries are based on a period of abstinence from MSM, often of 12 months duration. Several countries (Italy, Spain and Portugal) defer donors based on sexual behaviours considered to be at high risk, regardless of whether the partner is same sex or opposite sex. Compliance is a key determinant in the efficacy of any deferral policy. We summarize research themes and strategies discussed at a January 2017 meeting held in Toronto, Canada, to provide an evidence basis for future policy changes.Key words: donor deferrals, men who have sex with men.

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“…However, the positively selected positions detected, and particularly nef H89F, might be associated with the already reported high plasma viral loads in the infected patients, that could have facilitated transmission. At this point, it is important to note that variants from this cluster have already been detected in seven Spanish regions, the last cases described in Catalonia (Bes et al, 2017). Also, unpublished results have recently shown the rapid expansion of a new F1 subcluster, closely related with the Spanish variant, presenting 188 reported cases between MSM (Vinken et al, 2017).…”

Section: Discussionmentioning

confidence: 80%

Genome-scale analysis of evolutionary rate and selection in a fast-expanding Spanish cluster of HIV-1 subtype F1

Patiño-Galindo

Domı́nguez

Cuevas

et al. 2018

Infection, Genetics and Evolution

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This work is aimed at assessing the presence of positive selection and/or shifts of the evolutionary rate in a fast-expanding HIV-1 subtype F1 transmission cluster affecting men who have sex with men in Spain. We applied Bayesian coalescent phylogenetics and selection analyses to 23 full-coding region sequences from patients belonging to that cluster, along with other 19 F1 epidemiologically-unrelated sequences. A shift in the overall evolutionary rate of the virus, explained by positively selected sites in the cluster, was detected. We also found one substitution in Nef (H89F) that was specific to the cluster and experienced positive selection. These results suggest that fast transmission could have been facilitated by some inherent genetic properties of this HIV-1 variant.

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Epidemiological trends of HIV‐1 infection in blood donors from Catalonia, Spain (2005‐2014)

Cited by 11 publications

References 30 publications

The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014–2017

The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014–2017

Donor deferral policies for men who have sex with men: past, present and future

Genome-scale analysis of evolutionary rate and selection in a fast-expanding Spanish cluster of HIV-1 subtype F1

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