Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide populationbased study

Yen, Hsu‐Heng; Weng, Meng–Tzu; Tung, Chien‐Chih; Wang, Yuting; Chang, Yuan‐Ting; Chang, Chin‐Hao; Shieh, Ming‐Jium; Wong, Jau‐Min; Wei, Shu–Chen

doi:10.5217/ir.2018.00096

Cited by 115 publications

(120 citation statements)

References 31 publications

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“…However, the IBD population in Asian countries is expanding rapidly with the rising incidence. In Taiwan, the prevalence of CD and UC between 2001 and 2015 has increased from 0.6 and 2.1 to 3.9 and 12.8, respectively, per 100,000 individuals . In 2014, the adjusted prevalence of UC and CD in Hong Kong had risen to 24.5 and 18.6 per 100,000 individuals .…”

Section: Introductionmentioning

confidence: 99%

“…In Taiwan, the prevalence of CD and UC between 2001 and 2015 has increased from 0.6 and 2.1 to 3.9 and 12.8, respectively, per 100,000 individuals. 25 In 2014, the adjusted prevalence of UC and CD in Hong Kong had risen to 24.5 and 18.6 per 100,000 individuals. 26 Study from South Korea revealed similar trends, where the prevalence of UC quadrupled from 7.6 per 100,000 individuals in 1997 to 30.9 in 2005.…”

Section: Introductionmentioning

confidence: 99%

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The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

426

291

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The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of the heterogeneity of the disease and eventually assist in the discovery of novel therapeutic targets and design of preventive strategies. Comparison of population‐based data in East and West reveals that the incidence of IBD has risen rapidly in East while plateauing in West. Furthermore, the clinical presentation and course of IBD differs between East and West with more patients in East presenting with complicated disease. Considering the scarcity of population‐based data from East and the lack of studies with long durations of follow‐up, it remains to be clarified whether these differences reflect true differences in disease presentation. The effects of genetic and environmental risk factors contributing to IBD also differ between Eastern and Western populations. Considering the differential effects of genetic and environmental risk factors in East and West, future studies should seek to discover novel genetic and environmental risk factors which might specifically apply to eastern populations. In this narrative review, we compare the epidemiology of IBD between eastern and western countries by summarizing evidence from population‐based cohort studies in the last ten years. Furthermore, we look at differences in genetic susceptibility and environmental triggers of IBD between East and West.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

426

291

View full text Add to dashboard Cite

show abstract

“…[3] Although the incidence of IBD is low in Taiwan, the incidence and prevalence of IBD kept raising in the past decades. [4] The urge of understanding the pathogenesis of IBD and to facilitate the treatment strategy of IBD is growing. The most accepted hypothesis of IBD pathogenesis is an abnormal immune response against the gut microbiota that triggered by external environment in a genetically vulnerable host.…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan

Chang

Luo

Yang

et al. 2020

Preprint

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Background Inflammatory bowel disease (IBD) is a chronic inflammatory disease that associated with complicated interaction between immune, gut microbiota and environmental factors in a genetically vulnerable host. Dysbiosis is often seen in patients with IBD. Our aim is to investigate the fecal microbiota in patients with IBD and compared to healthy controls in Taiwan. Methods In this cross-sectional study, we investigated fecal microbiota in 20 patients with IBD and 48 healthy controls. Fecal samples from both IBD patients and controls were analyzed by next-generation sequencing method and relevant software. Results The IBD group showed lower bacterial richness and diversity compared to the control group. The principal coordinate analysis also revealed significant structural difference between the IBD group and the control group. These findings were consistent whether the analysis was based on operational taxonomic unit or amplicon sequence variant. However, no significant difference was found when comparing the composition of fecal microbiota between ulcerative colitis (UC) and Crohn’s disease (CD). Further analysis showed that Lactobacillus, Enterococcus, Bifidobacterium and Veillonella were dominant in the IBD group, while Faecalibacterium and Subdoligranulum were dominant in the control group at genus level. When comparing UC, CD and control group, Lactobacillus, Bifidobacterium and Enterococcus were identified as dominant genera in the UC group. Fusobacterium and Escherichia_Shigella were dominant in the CD group. Faecalibacterium and Subdoligranulum were dominant in the control group. Conclusions Compared to the healthy control, the IBD group showed dysbiosis with a significant decreased in both richness and diversity of gut microbiota.

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“…Crohn's disease (CD) is a chronic, relapsing, inflammatory intestinal disorder and affects numerous individuals worldwide. Currently, its occurrence is considered stable or decreasing in Western countries; however, its incidence has been dramatically rising in China [1][2][3] .…”

Section: Introductionmentioning

confidence: 99%

Microscopic features of small bowel mucosa of patients with Crohn’s disease

Cui

et al. 2019

Preprint

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Background Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aimed to explore the small bowel mucosal histopathologic characters of Crohn’s disease and identify some disease-specific changes. Methods We included 253 patients without tumors and grouped them into Crohn’s disease, suspected Crohn’s disease, and non-Crohn’s disease groups. These patients underwent double-balloon endoscopy examination and small bowel biopsy at Renji Hospital, Shanghai. All histopathological sections were reviewed, and >20 histopathological parameters were assessed. Immunohistochemistry was conducted when necessary. Results There were different forms of granulomatous lymphangitis on the small bowel mucosa in Crohn’s disease. They showed as various macrophages or epithelioid cells in the lumina of lymphatics or in the center of the villi with or without evident obstruction. These features were only observed in Crohn’s disease patients. Furthermore, they were correlated with granuloma and lymphangiectasia. Additionally, 15 other features showed significant differences among the three groups, and Crohn’s disease patients showed an average of almost seven histopathological characteristics. Conclusions We described the detailed morphologies of granulomatous lymphangitis on the small bowel mucosa and recommend it as a useful histopathological feature for the diagnosis of Crohn’s disease. In terms of specificity and sensitivity, it was superior to non-caseating epithelioid granuloma.

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Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide populationbased study

Cited by 115 publications

References 31 publications

The epidemiology of inflammatory bowel disease: East meets west

The epidemiology of inflammatory bowel disease: East meets west

Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan

Microscopic features of small bowel mucosa of patients with Crohn’s disease

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