Epidemiological Survey of Babesia gibsoni Infection in Dogs in Eastern Japan

Miyama, Takako Shimokawa; Sakata, Yoshimi; Shimada, Yojiro; Ogino, Shoji; Watanabe, Malaika; Itamoto, Kazuhito; Okuda, Masaru; Verdida, Rodolfo A.; Xu, Xuan; Nagasawa, Hideyuki; Inokuma, Hisashi

doi:10.1292/jvms.67.467

Cited by 66 publications

(42 citation statements)

References 20 publications

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“…(Fig. 3) which were confirmed to be Babesia gibsoni by PCR using B. gibsoni specific primer (Miyama et al 2005;Fig. 4).…”

Section: Case History and Clinical Observationmentioning

confidence: 78%

“…Traditionally, all small canine piroplasms are identified as B. gibsoni based on blood smear examination assuming that no other small Babesia species infects dogs hence it was tentatively diagnosed as B. gibsoni based on blood smear examination. The final confirmation was made based of PCR assay (Miyama et al 2005). The therapy targeting babesiosis was carried out with a single dose of diminazene aceturate @ 3.5 mg/kg body weight deep I/M with oral combination of doxycycline, enrofloxacin and metronidazole with dose rate of 5, 3 and 10 mg/kg body weight, respectively for 21 days.…”

Section: Treatment and Discussionmentioning

confidence: 99%

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A unique case of Babesia gibsoni infected dog with paraplegia

et al. 2016

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A 4 year old male Rottweiler was presented to Teaching Veterinary Clinics of GADVASU with a primary complaint of paraplegia, fever and inappetence. The dog was found to be dull with elevated rectal temperature (105°F), heart rate (158 per minute) and respiration rate (57 per minute). Blood smear examination and PCR assay revealed that dog was positive for Babesia gibsoni. Elevated bilirubin, alanine aminotransferase, alkaline phosphatase, creatinine, total leucocyte count, neutrophils and hypoglycaemia were haemato-biochemical alterations. The therapy targeting babesiosis was carried out with a single dose of diminazene aceturate in combination with doxycycline, enrofloxacin and metronidazole for 21 days. Complete follow up of the case revealed complete clinical recovery within 21 days.

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“…(Fig. 3) which were confirmed to be Babesia gibsoni by PCR using B. gibsoni specific primer (Miyama et al 2005;Fig. 4).…”

Section: Case History and Clinical Observationmentioning

confidence: 78%

Section: Treatment and Discussionmentioning

confidence: 99%

A unique case of Babesia gibsoni infected dog with paraplegia

et al. 2016

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“…B. gibsoni infection is endemic in many regions in Asia, Africa, Europe, Australia, Brazil, and North America [4,10]. In Japan, B. gibsoni infection has long been problematic especially in western regions, but recently the distribution appears to be expanding to the eastern parts of Japan [21].…”

mentioning

confidence: 99%

Evaluation of Efficacy of Bruceine A, a Natural Quassinoid Compound Extracted from a Medicinal Plant, Bruced javanica, for Canine Babesiosis

Mizukami

Kawamura

subeki

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Bruceine A, a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) Merr., was evaluated for its antibabesial activity in vitro and in vivo. Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection. An untreated dog developed typical acute babesiosis symptoms including severe anemia, high fever, and complete loss of appetite and movement. However, the two bruceine A-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks although complete elimination of parasites from the peripheral blood was not achieved and decreases in the packed cell volume and the erythrocyte and platelet counts were observed. Since natural quassinoid compounds have been used as traditional medicines for the treatment of various ailments including cancer and malaria, the present results suggest that bruceine A or other related compounds are potential candidates for the treatment of canine babesiosis.

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“…B. gibsoni infected dogs are generally seen in the west of Japan and dogs affected by B. canis are mainly observed on Okinawa island. However, the incidence of canine babesiosis, especially B. gibsoni infection, has been recently reported to be increasing, and the areas affected are expanding towards the northeastern part of Japan [15,17,27]. Clinical symptoms of canine babesiosis include anorexia, depression and exercise intolerance as a result of hemolytic anemia.…”

mentioning

confidence: 99%

A Possible Treatment Strategy and Clinical Factors to Estimate the Treatment Response in Bebesia gibsoni Infection

Suzuki¹,

Wakabayashi²,

Takahashi

et al. 2007

J. Vet. Med. Sci.

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ABSTRACT. The effectiveness of combination therapy using clindamycin, metronidazole and doxycycline against canine babesiosis, and the usefulness of platelet count and the plasma C-reactive protein (CRP) concentration as an estimation factor for treatment, were evaluated in four dogs experimentally infected with Babesia gibsoni. The combination therapy successfully eliminated B. gibsoni in peripheral blood in 3 of 4 dogs, however the remaining dog showed obvious uncontrolled relapse after a temporary recovery. In addition, it was shown that CRP levels decreased in an inverse relationship to the recovery of packed cell volume and therefore CRP levels could be used as an optional clinical marker to estimate the response to treatment. KEY WORDS: babesia, canine, treatment.

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Epidemiological Survey of Babesia gibsoni Infection in Dogs in Eastern Japan

Cited by 66 publications

References 20 publications

A unique case of Babesia gibsoni infected dog with paraplegia

A unique case of Babesia gibsoni infected dog with paraplegia

Evaluation of Efficacy of Bruceine A, a Natural Quassinoid Compound Extracted from a Medicinal Plant, Bruced javanica, for Canine Babesiosis

A Possible Treatment Strategy and Clinical Factors to Estimate the Treatment Response in Bebesia gibsoni Infection

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