Epidemiological Study of Orofacial Clefts among Population of Eastern Slovakia during the Period 1996-2013

Abstract

SUMMARYBackground and Aim: Over the past 18 years, according to data from the Clinic of Plastic and Reconstructive Surgery, L. Pasteur University Hospital, there have been 493 cases of orofacial clefts (OC) reported in the area of Eastern Slovakia. The aim of this study was to map the occurrence of orofacial clefts reported in the area of Eastern Slovakia during the years 1996-2013. Also, we compared the occurrence of different types of clefts between the groups in relation to gender and ethnicity. Methods and Results:The statistical analysis shows relationship between variables of location and gender and gender differences in the occurrence of various types of clefts. Moreover, in comparison with another study which analyzed the years 1985-2000 (1.29/10 3 live births), there was an increase in the incidence (1.42/10 3 live births) of OC in Eastern Slovakia. Conclusion: Our findings seem contradictive to similar studies which discuss ethnic differences in relation to OC. We recognize the relatively high occurrence of OC in Eastern Slovakia, and we link this phenomenon to several extrinsic factors, in particular socioeconomic status and embryotoxic factors.

Ensino, pesquisa e contribuições científicas em odontologia

“…Tolarova e Cervenka (1998) estimaram que 60% a 80% dos pacientes com FL/P eram homens na amostra por eles avaliada na Califórnia, Estados Unidos. Algumas pesquisas mostram que a diferença não é estatisticamente significativa, como o caso do presente estudo (CUOZZO et al, 2013;KIANIFAR et al, 2015;PACÁKOVÁ et al, 2016). De modo contrário, Maia et al (2019), observaram que o sexo feminino era o mais acometido por FL/P.…”

“…Em relação ao fenótipo, as fissuras de palato foram mais frequentes entre as mulheres e a fissuras de lábio isolada e de lábio com palato predominaram nos homens, características que corroboram os relatos de conjuntos de dados nacionais e mundiais (ANTOSZEWSKI;FIJAŁKOWSKA, 2016;COUTINHO et al, 2009;CUOZZO et al, 2013;FERRARI-PILONI;JESUÍNO, 2021;HLONGWA;LEVIN;RISPEL, 2019;IMPELLIZZERI et al, 2019;MARTELLI et al, 2012;MENEZES et al, 2010;PACÁKOVÁ et al, 2016;PANG;BROYLES;REDETT, 2013). Martelli et al (2012) (KIANIFAR et al, 2015), Austrália (LO et al, 2015) e China (FAN et al, 2018).…”

“…Aproximadamente 70% das FL/P são consideradas não sindrômicas ou isoladas, cujos indivíduos afetados não apresentam qualquer outra anomalia estrutural associada, enquanto as 30% restantes são atribuídas a fissuras sindrômicas (NOPOULOS et al, MURRAY, 2002). No Brasil, estima-se que a incidência de FL/P não sindrômicas seja de 0,99 casos para cada 1000 nascidos (PANAMONTA et al, 2015), sendo observado que os indivíduos de descendência asiática ou de índios americanos apresentam maior incidência dessa alteração, enquanto nos africanos isso se reduz (BEKELE;EKANEM;MEBERATE, 2019;DIXON et al, 2011;NATSUME et al, 1987).…”

An ecological study on orofacial clefts in northeastern Brazil

“…They are congenital anomalies characterized by failures that compromise the fusion between frontonasal and maxillary processes, causing cleft lip and/or fusion of palatal plates of the maxillary process, leading to the development of cleft palate (2). Face embryogenesis occurs around the 8 th to 12 th week of intrauterine life, providing typical human appearance to the fetus (3); however, this process may be significantly affected by teratogenic agents (drugs, radiation, environmental conditions), as well as by genetic factors that are associated with the chromosomal disposition of each individual, so that cases of malformations may manifest in isolation or associated with syndromes (4).…”

3D longitudinal evaluation of dental arch in children with unilateral cleft lip and palate

“…Usually the studies only focus on the dimensional analyses of the dental arches of children with cleft lip and palate (HUANG et al, 2002;FUCHIGAMI et al, 2011;PUCCIARELLI et al, 2015;CÉRON-ZAPATA et al, 2016;HOFFMANNOVA et al, 2016;JORGE et al, 2016) because this is the most prevalent type (CYMROT et al, 2010;NEVES et al, 2016;PACÁKOVÁ et al, 2016). The studies comprise the assessment of different corrective surgical techniques , analyses of rehabilitative protocols FUCHIGAMI et al, 2011;PUCCIARELLI et al, 2015;CÉRON-ZAPATA et al, 2016;HOFFMANNOVA et al, 2016;JORGE et al, 2016), and comparison of the cleft subtypes (HONDA et al, 1995;LO et al, 2003;HARILA et al, 2013;FERNANDES et al, 2015).…”