Epidemiological study of mortality in epilepsy in a Spanish population

Chamorro-Muñoz, M.I.; Martín, Guillermina García; Pérez-Errazquín, F; Romero-Acebal, Manuel; Garcı́a-Rodrı́guez, A.; Gutiérrez‐Bedmar, Mario

doi:10.1016/j.seizure.2017.02.004

Cited by 14 publications

(14 citation statements)

References 29 publications

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“…Similar results have been reported by Neligan et al 13 for the United Kingdom and Loiseau et al 14 for southern France, although in this second study, the patients were only followed for 1 year. The study conducted by Chamorro-Muñoz et al 8 in southern Spain, which had a similar follow-up duration to ours and was also performed in an outpatient setting, detected an SMR of 2.11, but this lower rate can probably be explained by differences in patient selection. In our series, mortality was most marked in middle-aged adults, whereas in the study by Chamorro-Muñoz et al, it was higher in the younger age-groups.…”

Section: Discussionsupporting

confidence: 71%

Incidence and mortality in adults with epilepsy in northern Spain

et al. 2020

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According to a recent report by the World Health Organization, 1 epilepsy is one of the most common neurologic diseases worldwide, with an estimated prevalence of 50 million cases. Patients with epilepsy are three times more likely to die than the general population. 1 The estimated global incidence of epilepsy is 61.4 cases per 100,000 inhabitants a year, although rates are lower in more developed countries. 1 One of the largest epidemiologic studies of epilepsy to date found an incidence of 44 cases per 100,000 population. 2 In Europe, the incidence in adults has been reported at between 24 and 56 cases, 3 while closer to our region, in southwest France, the rate is 71 cases per 100,000 population, but this includes single seizures. 4

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Section: Discussionsupporting

confidence: 71%

Incidence and mortality in adults with epilepsy in northern Spain

et al. 2020

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“…This may require better screening and early treatment for those at risk. The increased risk of suicide in also worrying and occurred in multiple older and newer studies worldwide (Chamorro-Munoz et al 2017;Chang et al 2012;Day et al 2005;Ding et al 2006;Ding et al 2013;Granbichler et al 2015;Mohanraj et al 2006;Mu et al 2011;Rafnsson et al 2001;Shackleton et al 1999;White et al 1979). It may be that more needs to be done to manage mental health problems in PWE.…”

Section: J O U R N a L P R E -P R O O F 18mentioning

confidence: 99%

Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews

et al. 2019

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In the elderly general population, fracture is associated with mortality and chronic diseases, and postfracture chronic disease development may be involved in the fracture‐mortality association . The most common causes of death for individuals with epilepsy include chronic diseases (eg, cardiovascular and respiratory disease), injuries (eg, seizures, falls), and cancer . Therefore, the current study provides new potential insights into factors that may be involved directly with mortality or indirectly with mortality via early pathological processes for adults with epilepsy, as NTFx is an adverse outcome of injuries (eg, seizures, falls) and increases risk of chronic diseases.…”

Section: Discussionmentioning

confidence: 93%

The mortality burden attributable to nontrauma fracture for privately insured adults with epilepsy

et al. 2020

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Objective: Individuals with epilepsy have poor bone development and preservation throughout the lifespan and are vulnerable to nontrauma fracture (NTFx) and post-NTFx complications. However, no studies have examined the contribution of NTFx to mortality among adults with epilepsy. The objective was to determine whether NTFx is a risk factor for mortality among adults with epilepsy. Methods: Data from 2011 to 2016 were obtained from Optum Clinformatics Data Mart, a nationwide claims database from a single private payer in the United States.Diagnosis codes were used to identify adults (≥18 years old) with epilepsy, NTFx, and covariates (demographics and pre-NTFx cardiovascular disease, respiratory disease, diabetes, chronic kidney disease, cancer). Crude mortality rate per 100 person-years was estimated. Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs) were determined for mortality, comparing epilepsy and NTFx (EP + NTFx; n = 11 471), epilepsy without NTFx = 6.8 million)after adjusting for covariates. Results: The 3-, 6-, and 12-month crude mortality rates were highest among EP + NTFx (12-month mortality rate = 8.79), followed by without EP + NTFx (12month mortality rate = 4.80), EP without NTFx (12-month mortality rate = 3.06), and without EP without NTFx (12-month mortality rate = 0.47). After adjustments, the mortality rate was elevated for EP + NTFx for all time points compared to EP without NTFx (eg, 12-month HR = 1.70, 95% CI = 1.58-1.85), without EP + NTFx (eg, 12-month HR = 1.41, 95% CI = 1.32-1.51), and without EP without NTFx (eg, 12-month HR = 5.23, 95% CI = 4.88-5.60). Stratified analyses showed higher adjusted HRs of 12-month mortality for EP + NTFx for all NTFx sites (ie, vertebral column, hip, extremities), all age categories (young, middle-aged, older), and for both women and men. Significance: Among adults with epilepsy and compared to adults without epilepsy, NTFx is associated with a higher 12-month mortality rate. Findings suggest that NTFx may be a robust risk factor for mortality among adults with epilepsy.

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Epidemiological study of mortality in epilepsy in a Spanish population

Cited by 14 publications

References 29 publications

Incidence and mortality in adults with epilepsy in northern Spain

Incidence and mortality in adults with epilepsy in northern Spain

Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews

The mortality burden attributable to nontrauma fracture for privately insured adults with epilepsy

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