Epidemiological study of Chlamydia trachomatis infection in pregnant women in Hungary

Abstract

A multicentre survey was carried out in order to determine the prevalence and risk factors of Chlamydia trachomatis infection in the pregnant population in Hungary. The nucleic acid hybridisation method (PACE 2 Gen-Probe) was applied for the examination of C trachomatis. The overall average prevalence of C trachomatis cases during an 18 month survey on 6161 pregnant women was 5.87%. There were significant diVerences in the proportions of chlamydial infection in the diVerent survey centres, and also in the diVerent age groups and the diVerent family status groups. The perinatal mortality rate exhibited a significantly higher prevalence (8.52%) among C trachomatis positive than among negative patients (2.03%). In the anamnestic histories of C trachomatis infected patients, the frequency of premature uterine activity was 8.13%, in contrast with 5.18% in the non-infected group (p<0.05). We suggest that all pregnant women be tested for C trachomatis infection. (Sex Transm Inf 1998;74:213-215)

Screening pregnant women for chlamydia: what are the predictors of infection?

“…However, none of these other studies assessed the women’s recent sexual risk nor did any provide the participation rates for their study 19 – 21. In our study, having more than one sexual partner in the past year was, in fact, the strongest predictor of chlamydia infection and remained so after adjustment for other factors, including age.…”

Chlamydia trachomatis infection and the risk of perinatal mortality in Hungary

“…A large number of anecdotal observations suggest that C. trachomatis infections may have a causative role in the origin of premature delivery [5,7,14]. Consequently, a multicenter survey was carried out in order to determine the prevalence and risk factors for C. trachomatis infection in the pregnant population in Hungary [8] as Nyári has reported. The data set of the Hungarian survey was reanalyzed in order to provide further information on the relationship between neonatal mortality and genital chlamydial infections and to estimate the frequency of these infections.…”

Prevalencia de Chlamydia Trachomatis detectada por reacción en cadena de la polimerasa en un grupo de mujeres jóvenes sintomáticas y asintomáticas en Bogotá, Colombia

“…La prevalencia de infección fue 5,6% (IC 95% 3,7-9,1) en el grupo total, 7,8% (IC 95% 4,7-13,7) en las pacientes con leucorrea y 3,4% (IC 95% 1,3-7,6) en las mujeres asintomáticas. Hubo 14 muestras positivas para Chlamydia en mujeres con clasifi cación socioeconómica baja y 6 en mujeres con clase socioeconómica media (OR 4,4 IC95% 1, [5][6][7][8][9][10][11][12][13][14]4). De las 20 mujeres con resultado positivo para C. trachomatis, 9 (45%) convivían en unión estable, 8 (40%) eran solteras y 3 (15%) eran casadas.…”

“…11 Desde el punto de vista obstétrico y perinatal, la infección por C. trachomatis se ha asociado con aborto, restricción del crecimiento intrauterino, ruptura prematura de membranas, parto pretérmino, endometritis puerperal y conjuntivitis y neumonía en el recién nacido. [12][13][14][15] El cuadro clínico silente o inespecífi co hace necesario el uso de pruebas de laboratorio para el diagnóstico de la infección por Chamydia trachomatis. Se han utilizado muestras uretrales, cervicales y de orina para cultivos o detección de antígenos por diferentes técnicas inmunológicas, detección de anticuerpos séricos, 16 análisis de sonda génica amplificada (AMP), 17 reacción en cadena de la polimerasa (PCR) y reacción en cadena de la ligasa (LCR).…”