Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002

Guzmán, María G.; Alvárez, A.; Vázquez, Susana; Álvarez, Mayling; Rosario, Delfina; Peláez, Otto; Cruz, Gerardo López; Rodríguez, R; Pavón, Alequis; González, Annia Fong; Morier, Luís; Ruiz, Didye; Kourı́, Gustavo; Halstead, Scott B.

doi:10.1016/j.ijid.2011.09.026

Cited by 30 publications

(26 citation statements)

References 34 publications

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“…According to PAHO, other Hispanic Caribbean countries did not report this serotype in those years. The last detection of dengue 3 (genotype III) in Cuba was during a big epidemic in 2001 and 2002 [14,34]. …”

Section: Discussionmentioning

confidence: 99%

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative

et al. 2017

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We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012–13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014). We were able to characterise dengue viruses imported from regions where currently no virological surveillance data are available. Up to 36% of travellers infected with dengue while travelling returned during the acute phase of the infection (up to 7 days after symptom onset) or became symptomatic after returning to Europe, and 58% of the patients with acute dengue infection were viraemic when seeking medical care. Epidemiological and virological data from dengue-infected international travellers can add an important layer to global surveillance efforts. A considerable number of dengue-infected travellers are viraemic after arrival back home, which poses a risk for dengue introduction and autochthonous transmission in European regions where suitable mosquito vectors are prevalent.

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Section: Discussionmentioning

confidence: 99%

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative

et al. 2017

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“…20 However, there are few studies on the incidence of dengue disease after a third or fourth dengue infection. [21][22][23] Data presented compare the inflammatory/anti-inflammatory response after primary, secondary, tertiary, and quaternary challenge. Our results confirm that primary dengue challenge induces TNF-α, IFN-γ, IL-10, and TGF-β expression at early stages after infection, but notably lower than the secondary exposure.…”

Section: Discussionmentioning

confidence: 99%

Variation in Inflammatory/Regulatory Cytokines in Secondary, Tertiary, and Quaternary Challenges with Dengue Virus

Sierra

Pérez²,

Álvarez³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Secondary heterologous dengue infection is a risk factor for severe disease manifestations because of the immune-enhancement phenomenon. Succeeding clinical infections are seldom reported, and the clinical course of tertiary and quaternary dengue infections is not clear. Cuba represents a unique environment to study tertiary/quaternary dengue infections in a population with known clinical and serologic dengue markers and no dengue endemicity. We took advantage of this exceptional epidemiologic condition to study the effect of primary, secondary, tertiary, and quaternary dengue infection exposure on the expression of pro-inflammatory and regulatory cytokines, critical in dengue infection pathogenesis, by using a dengue infection ex vivo model. Whereas secondary exposure induced a high cytokine response, we found a significantly lower expression of tumor necrosis factor-α, interferon-γ, interleukin-10, and tumor growth factor-β after tertiary and quaternary infectious challenge. Significant differences in expression of the cytokines were seen between the dengue immune profiles, suggesting that the sequence in which the immune system encounters serotypes may be important in determining the nature of the immune response to subsequent infections.

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“…DENV-3 isolates, other than genotype III, have been reported in Colombia [54] and in the Brazilian states of Minas Gerais and Rondonia, likely imported from Asia [55], [56]. The successive circulation of different genotypes is of public health concern given that distinct combinations could have different epidemic potentials and risk burdens [57].…”

Section: Resultsmentioning

confidence: 99%

Dengue Virus Type 3 Adaptive Changes during Epidemics in São Jose de Rio Preto, Brazil, 2006–2007

et al. 2013

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Global dengue virus spread in tropical and sub-tropical regions has become a major international public health concern. It is evident that DENV genetic diversity plays a significant role in the immunopathology of the disease and that the identification of polymorphisms associated with adaptive responses is important for vaccine development. The investigation of naturally occurring genomic variants may play an important role in the comprehension of different adaptive strategies used by these mutants to evade the human immune system. In order to elucidate this role we sequenced the complete polyprotein-coding region of thirty-three DENV-3 isolates to characterize variants circulating under high endemicity in the city of São José de Rio Preto, Brazil, during the onset of the 2006-07 epidemic. By inferring the evolutionary history on a local-scale and estimating rates of synonymous (dS) and nonsynonimous (dN) substitutions, we have documented at least two different introductions of DENV-3 into the city and detected 10 polymorphic codon sites under significant positive selection (dN/dS > 1) and 8 under significant purifying selection (dN/dS < 1). We found several polymorphic amino acid coding sites in the envelope (15), NS1 (17), NS2A (11), and NS5 (24) genes, which suggests that these genes may be experiencing relatively recent adaptive changes. Furthermore, some polymorphisms correlated with changes in the immunogenicity of several epitopes. Our study highlights the existence of significant and informative DENV variability at the spatio-temporal scale of an urban outbreak.

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Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002

Abstract: The results obtained highlight the role of the infecting serotype and also the sequence of the viral infection in the clinical outcome of a dengue infection.

Cited by 30 publications

References 34 publications

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative

Variation in Inflammatory/Regulatory Cytokines in Secondary, Tertiary, and Quaternary Challenges with Dengue Virus

Dengue Virus Type 3 Adaptive Changes during Epidemics in São Jose de Rio Preto, Brazil, 2006–2007

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