Epidemiological Status of Thyroid Eye Disease in Central Iran

Eshraghi, Bahram; Nikdel, Mojgan; Abbasi, Maryam

doi:10.4103/joco.joco_223_21

Cited by 3 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been investigated in the Iranian population in recent years, and 36% of all thyroid patients have been reported, of which 90% indicated hyperthyroidism in their primary status. [ 21 – 25 ] Since there is insufficient data on the characteristics and natural history of TED in our country, setting up a registry system for such a disease seemed high priority. A patient registry applies observational study methods to compose comprehensive evidence regarding clinical features of all cases of a particular condition or all subjects of a specified disease in a specific population.…”

Section: Introductionmentioning

confidence: 99%

Implementation of thyroid eye disease registry in Iran: rationale and research protocol

Akbarian,

Sheikhtaheri,

Khorrami

et al. 2024

Orphanet J Rare Dis

View full text Add to dashboard Cite

Background To describe the implementation of a registry system for patients with thyroid eye disease (TED) in Iran to obtain more information about its nature, prevalence, and annual incidence, as well as extend insight into the etiology, pathogenesis, and eventually make an accurate prognosis of different medical or surgical treatment methods. Methods After receiving approval from the Disease Registry Committee of Iran University of Medical Sciences (IUMS) in 2019 and the Ministry of Health and Medical Education (MOHME) in 2020, the protocol was introduced in three consecutive phases at regional, provincial and national levels. The establishment of a registry committee in Rassoul Akram Hospital, one of the medical centers affiliated to IUMS, was the first step to organizing the registry project's main core. The steering committee included six subgroups of required subject fields. The members are experts in developing a guideline, providing a new dataset, drawing an outline for the next steps, and structuring user-friendly software through several panel discussion meetings. The data is collected from clinical and para-clinical/imaging findings, laboratory evaluations, and their selected treatment strategy, retrospectively and prospectively. Results The purpose is to broaden our knowledge about the profile of TED; accordingly, data related to patients’ demographics, thyroid gland disease (status, duration, treatments, and function tests), general medical and ocular history, along with visual/ocular exams resulting TED status are collected and recorded in a 2- language software. The web-based software system is accessible at https://orc.iums.ac.ir. To maintain data security, prioritized user access was defined for different members. Furthermore, diverse methods, such as employing trained staff and utilizing software validation rules, were implemented to control data quality in every step of data collection, entry, and registration. Medical records of retrospective subjects were also evaluated and entered after accuracy verification. Conclusion Iran's TED registry provides practitioners with comprehensive data on natural history and phenotype variations in clinical features and outcomes. It facilitates patient recruitment and, consequently, earlier diagnosis on a large scale which helps improve treatment and quality of life for patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Implementation of thyroid eye disease registry in Iran: rationale and research protocol

Akbarian,

Sheikhtaheri,

Khorrami

et al. 2024

Orphanet J Rare Dis

View full text Add to dashboard Cite

show abstract

“…It has also been investigated in the Iranian population in recent years, and 36% of all thyroid patients have been reported, of which 90% indicated hyperthyroidism in their primary status. [21][22][23][24][25] Since there is insu cient data on the characteristics and natural history of TED in our country, setting up a registry system for such a disease seemed high priority. A patient registry applies observational study methods to compose comprehensive evidence regarding clinical features of all cases of a particular condition or all subjects of a speci ed disease in a speci c population.…”

Section: Introductionmentioning

confidence: 99%

Implementation of Thyroid Eye Disease Registry in Iran: Rationale and Research Protocol

Akbarian

Sheikhtaheri

Khorrami

et al. 2023

Preprint

View full text Add to dashboard Cite

Background To describe the implementation of a registry system for patients with thyroid eye disease (TED) in Iran to obtain more information about its nature, prevalence, and annual incidence, as well as extend insight into the etiology, pathogenesis, and eventually make an accurate prognosis of different medical or surgical treatment methods. Methods After receiving approval from the Disease Registry Committee of Iran University of Medical Sciences (IUMS) in 2019 and the Ministry of Health and Medical Education (MOHME) in 2020, the protocol was introduced in three consecutive phases at regional, provincial and national levels. The establishment of a registry committee in Rassoul Akram Hospital was the first step to organizing the registry project's main core. The steering committee included six subgroups of required subject fields. The members are experts in developing a guideline, providing a new dataset, drawing an outline for the next steps, and structuring user-friendly software through several panel discussion meetings. The data is collected from clinical and para-clinical/imaging findings, laboratory evaluations, and their selected treatment strategy, retrospectively and prospectively. Results The purpose is to broaden our knowledge about the profile of TED; accordingly, data related to patients’ demographics, thyroid gland disease (status, duration, treatments, and function tests), general medical and ocular history, along with visual/ocular exams resulting TED status are collected and recorded in a 2- language software. The web-based software system is accessible at https://orc.iums.ac.ir. To maintain data security, prioritized user access was defined for different members. Furthermore, diverse methods, such as employing trained staff and utilizing software validation rules, were implemented to control data quality in every step of data collection, entry, and registration. Medical records of retrospective subjects were also evaluated and entered after accuracy verification. Conclusion Iran's TED registry provides practitioners with comprehensive data on natural history and phenotype variations in clinical features and outcomes. It facilitates patient recruitment and, consequently, earlier diagnosis on a large scale which helps improve treatment and quality of life for patients.

show abstract

Prevalence of Thyroid Dysfunction Disorders among Adult Populations in the Middle–East: A Systematic Review and Meta-analysis

Kargar,

Tabatabaei,

Okati-Aliabad

et al. 2024

TOPHJ

View full text Add to dashboard Cite

Background Thyroid dysfunction is a systemic disorder that causes severe morbidity and is a public health problem worldwide. This study aimed to evaluate the prevalence of thyroid dysfunction among adults in the Middle East. Methods and Materials We searched PubMed, Google Scholar, and Medline databases from 2000–2021 to identify studies that presented the prevalence of thyroid dysfunction, hypothyroidism, subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism in the Middle East. A random-effects model was used to calculate the pooled prevalence and confidence intervals of thyroid dysfunction. The data were analyzed using STATA-V14. Results Generally, 345 studies had eligible criteria to be included in this meta-analysis. The pooled prevalence of thyroid disorders, overt hypothyroidism, subclinical hypothyroidism, overt hyperthyroidism, and subclinical hyperthyroidism in the Middle East were 19.2% (95% CI: 11.0 – 33.2), 7.2% (95% CI: 3.6 – 14.3), 8.3% (95% CI: 5.3 – 13.0), 2.4% (95% CI: 1.4– 3.9), and 3.2% (95% CI: 2.1 – 4.7), respectively. Moreover, the prevalence of thyroid disorders increased from 15.2% (95% CI: 9.8-23.6) to 31.5% (95% CI: 22.5- 44.2) between 2000 and 2022. Conclusions Current meta-analysis suggests that thyroid disorders are more prevalent among adults in the Middle East. Moreover, with an increasing trend in the prevalence of thyroid disorders during the last two decades, early screening and prevention of the disease should be practiced.

show abstract

Epidemiological Status of Thyroid Eye Disease in Central Iran

Cited by 3 publications

References 28 publications

Implementation of thyroid eye disease registry in Iran: rationale and research protocol

Implementation of thyroid eye disease registry in Iran: rationale and research protocol

Implementation of Thyroid Eye Disease Registry in Iran: Rationale and Research Protocol

Prevalence of Thyroid Dysfunction Disorders among Adult Populations in the Middle–East: A Systematic Review and Meta-analysis

Contact Info

Product

Resources

About