Epidemiological Situation on Tick-Borne Borreliosis in the Russian Federation in 2021 and Forecast for 2022

Рудакова, С. А.; Теслова, О. Е.; Mutalinova, N. E.; Пеньевская, Н. А.; Рудаков, Н. В.; Савельев, Д. А.; Kuz’menko, Yu. F.

doi:10.21055/0370-1069-2022-2-46-53

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Полученные результаты совпадают с наблюдениями других авторов. Так, доля мужчин и женщин среди больных КБ примерно одинакова на разных территориях [7,18], а преобладание среди больных КЭ мужчин оказалось характерно и для других территорий [19][20][21]. Различия гендерной структуры больных КЭ и КБ более выражены среди лиц трудоспособного возраста: в 2017-2021 гг.…”

Section: материалы и методы исследованияunclassified

“…Для обеих инфекций характерно преобладание среди больных городского населения, доля которого выросла в современный период по сравнению с началом века. Эта же картина характерна в целом для многих эндемичных регионов страны [5][6][7]…”

Section: материалы и методы исследованияunclassified

“…По территории Республики Карелия (РК) проходит северная граница ареала I. persulcatus и I. ricinus -основных переносчиков КЭ и КБ в России [6][7][8]. Несмотря на то, что республика не относится к лидерам по уровню заболеваемости КБ и КЭ, но с 2000 г. показатели заболеваемости КЭ ежегодно превышают среднефедеральные в 1,3-4,6 раза, КБ в течение 14 лет -в 1,3-2,5 раза.…”

Section: Introductionunclassified

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Similarities and differences in the characteristics of the epidemical process tick-borne encephalitis and Lyme borreliosis

Rubis,

Ekimova,

Safonova

et al. 2023

jour

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Objective: To identify common and distinctive characteristics of the epidemical process of tick-borne encephalitis and Lyme borreliosis on the example of the Republic of Karelia.Materials and methods. The frequency of infected tick bites, dynamics, intensity, territorial, gender, age and social features of the incidence of tick-borne encephalitis and Lyme borreliosis in 2000–2021 were analyzed according to official statistics, epidemiological examination of foci and laboratory studies. The results of studies of 2379 blood samples of adults who were not ill and not vaccinated against tick-borne encephalitis for the presence of antibodies to the virus were analyzed.Results. The virulence of ticks in 2000–2021 decreased from 23.6 to 1.3%, infection with borrelia at the level of 13.4– 38.4%. The average long-term incidence rates of tick-borne encephalitis and Lyme borreliosis were 6.2 and 6.6 per 100 thousand, the dynamics of incidence had an average pronounced downward trend, correlated with the dynamics of requests for medical care of the population affected by ticks. The main clinical form of tick–borne encephalitis is meningeal (48%). Non-erythemic forms of borreliosis in recent years amounted to 39.1%. Antibodies of class G to tick-borne encephalitis virus were detected in 11.8±0.7% of the examined individuals. The territory of risk of infection with tick-borne encephalitis and Lyme borreliosis is the central and eastern part of the south of the Republic, where I.persulcatus dominates. The proportion of urban residents among patients with both infections is higher, but the incidence of urban and rural populations did not have significant differences. The incidence rates of tick-borne borreliosis in persons aged 40-49, 50-59 and 60 years and older are 1.6-2.2 times higher than those of tick-borne encephalitis, but the difference is not significant. At working age, the percent of men is higher than women, there are no differences among the elderly.Conclusions: Similar and different features of the epidemic process of tick-borne encephalitis and tick-borne borreliosis have been identified, which should be taken to improving the detection of diseases, predicting the situation and planning preventive measures.

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Section: материалы и методы исследованияunclassified

Section: Introductionunclassified

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Similarities and differences in the characteristics of the epidemical process tick-borne encephalitis and Lyme borreliosis

Rubis,

Ekimova,

Safonova

et al. 2023

jour

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Geno-Species Composition of Borrelia Circulating on the Black Sea Coast of the Krasnodar Territory

Zaitseva,

Volynkina,

Vasil’eva

et al. 2024

Problemy Osobo Opasnykh Infektsii

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The aim of the study was to assess the current epidemiological situation on Ixodidae tick-borne borreliosis (ITBB) (2017–2022) on the Black Sea coast of the Krasnodar Territory, to study the species composition of Borrelia.Materials and methods. Ixodidae ticks, Ixodes ricinus, Haemaphysalis concinna, H. inermis, Rhipicephalus sanguineus, were examined for infection with tick-borne borreliosis pathogens, followed by DNA sequencing of isolates. Species identification of Borrelia was carried out based on analysis of the nucleotide sequence of the 16S rRNA gene fragment using BLAST algorithm. Additionally, the OspC genotype was determined for isolates of pathogenic genovariants through comparing the obtained sequences with reference ones in the MEGA 5 program. The data were processed applying the cartographic method using the QGIS 2.18 software.Results and discussion. Between 2017 and 2022, 101 cases were registered on the Black Sea coast of the Krasnodar Territory, which accounted for 1.6 % of all ITBB cases in the Krasnodar Territory. The number of complaints with tick bites in Sochi was up to 191.4 per 100 thousand population. During the study, the predominant Borrelia geno-species on the territory of the Black Sea coast of the Krasnodar Territory was determined using sequencing – Borrelia lusitaniae (78.1 %). The circulation of geno-species B. garinii (6.8 %), B. valasiana (5.7 %), B. afzelii (3.6 %), B. miyamotoi (2.6 %), B. tanukii, B. bissettii (1.6 % each) was also observed. For Borrelia pathogenic species, appurtenance to OspC geno-groups was ascertained: four isolates were assigned to invasive OspC geno-groups, of which three B. afzelii isolates were genogroup A8, one B. garinii isolate was G7. High rate of infection of ticks with Borrelia was recorded in the surveyed area (up to 94.5 %). Borrelia of pathogenic species account for only 10.4 % of the total number of isolates studied. Mostly, genovariants that rarely cause diseases in humans (B. lusitaniae, B. valasiana, B. bissettii) and non-pathogenic Borrelia (B. tanukii) were found, which indicates a low risk of infection with ITBB pathogens.

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Assessment of prognostic factors for differential diagnostics between mono- and mixed infection of the febrile form of tick-borne encephalitis

Ilyinskikh

Filatova

Семенова

et al. 2023

jour

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Objective: is to assess clinical and laboratory prognostic factors to develop a differential diagnostic model between the monoinfection of tick-borne encephalitis febrile form and the mixed infection of tick-borne encephalitis with Lyme borreliosis non-erythemal form at the onset of the disease.Materials and methods. The clinical examination involving 56 patients with tick-borne encephalitis febrile form (mean age: 46.1±3.1 years) and 27 patients with the mixed infection of tick-borne encephalitis with Lyme borreliosis non-erythemal form (mean age: 47.2±3.2 years) has resulted in the assessment of 65 clinical and laboratory parameters in the first week of the disease including 14 indicators of standard and extended hemogram profiles and 6 blood leukocyte indices. Pearson’s goodness-of-fit test was used for statistical analysis. The predictive values of the parameters were determined by the odds ratio and ROC analysis with AUC. The logistic regression model was developed using STATISTICA 12.0.Results. To make differential diagnosis between mono- and mixed infection at the onset of the disease the following hematological parameters with “average” or “good” predictive values can be used: band neutrophil count (AUC=0.65), the index of leukocytes and erythrocyte sedimentation rate ratio (AUC=0.66), erythrocyte sedimentation rate (AUC=0.70), neutrophil granularity intensity (AUC=0.66), neutrophil reactivity intensity (AUC=0.72) and reactive lymphocytes count (AUC= 0.72). A logistic regression model with a “very good” predictive value (AUC=0.83) is developed which includes the following four predictors: band neutrophil count, erythrocyte sedimentation rate, NEUT-RI and NEUT-GI in peripheral blood.Conclusion. The model is allowed to make a differential diagnosis between the mono- and the mixed infection of tick-borne encephalitis with good sensitivity and specificity values in the first week of disease.

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Epidemiological Situation on Tick-Borne Borreliosis in the Russian Federation in 2021 and Forecast for 2022

Cited by 3 publications

References 10 publications

Similarities and differences in the characteristics of the epidemical process tick-borne encephalitis and Lyme borreliosis

Similarities and differences in the characteristics of the epidemical process tick-borne encephalitis and Lyme borreliosis

Geno-Species Composition of Borrelia Circulating on the Black Sea Coast of the Krasnodar Territory

Assessment of prognostic factors for differential diagnostics between mono- and mixed infection of the febrile form of tick-borne encephalitis

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