Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center

Abstract

Background and Objectives Hospital-based cancer registry is an essential tool for augmentation of the standard of care, administration motive, and resource for population-based cancer registries. Here, we presented hospital-based brain tumor registry (HBBTR) to outline a comprehensive epidemiological data, both clinical and histopathological, as well as trends of central nervous system tumors. In addition, we compare this data with national brain tumor data as well as an international brain tumor registry. Materials and Methods For the generation of this 7-year HBBTR data of all primary intracranial tumors operated, diagnosed, and registered at the Department of Pathology, Sawai ManSingh, between January 1, 2013 and December 31, 2019, was collected, analyzed, and compared with Tata Memorial Hospital, National Institute of Mental Health and Neurosciences, and Central Brain Tumor Registry of the United States. Results A total of 3,526 patients were of primary intracranial tumors. Out of which, male patients were 1,982 (56.2%), while 1,544 (43.8%) were female patients. Maximum proportion of tumors was in fifth decade. Overall, pediatric and adult patients constituted of 15.5 and 84.5% of the cases, respectively. Among all primary intracranial tumors, meningiomas (20%) were most common followed by glioblastoma multiformat (18%) and least common were germ cell tumors (0.1%) followed by pineal tumors (0.3%). In pediatric cohort astrocytic tumors (30.1%) are most common followed by embryonal tumors (20.8%), while in adults meningiomas (23.1%) were most common followed by glioblastomas (20.3%). Our registry showed similar trends of tumors with national data as compared with international data in median age of presentation. Conclusion This HBBTRs provide prevalence of primary intracranial tumors at a tertiary care center and could be a part of population-based registry.

Clinico-epidemiological Profile of Primary Brain Tumours in North-Eastern Region of India:A Retrospective Single Institution Study

“…The male:female ratio of incidence of primary brain tumours in the North-Eastern population was 2.3:1 [10] which is almost similar to that in our study (2.1:1). In a study of the Indian population, the frequency of brain tumours is highest in the 5th decade, while our study shows the frequency to be highest in the 4th decade [8]. The most common presenting symptom was headache (53%), followed by vomiting (28%), which is comparable to the study of Western population, where headache was the most common symptom [9,11].…”

“…In our study and that of the western population, supratentorial tumours predominate over infratentorial tumours [11]. In our study, it was found that Glioblastoma and Astrocytomas are the two most common primary brain tumours, while in both the Indian and Western populations, Meningioma and Glioblastoma are the most common primary brain tumours [8,12]. Ependymomas represented 3% of all intracranial neoplasms in this study, which is equal to that in an Indian study [8] and comparable to 2% in western studies [8,9].…”

“…Recent advances in molecular biology have improved our understanding of glioma pathogenesis, and several clinically significant genetic alterations have been In our study, males (68%) outnumbered females (32%). In studies of the Indian population as well as the western population, the incidence of brain tumours is more common in men [8,9]. Study of brain tumours from North-East Indian population [10] showed the age of incidence was highest in 20-39 years age group which may be compared to that of our study (31-40 years followed by 21-30 years age group).…”