Epidemiological profile of patients hospitalized with candiduria in the Central-Western region of Brazil

Santana, Milena Melges Pesenti de; Hoffmann-Santos, Hugo Dias; Dias, Luciana Basili; Tadano, Tomoko; Karhawi, Abdon Salam Khaled; Dutra, Valéria; Cândido, Stephano Luiz; Hahn, Rosane Christine

doi:10.1016/j.riam.2019.04.006

Cited by 6 publications

(7 citation statements)

References 54 publications

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“…Previous studies have produced mixed results on which Candida species is more likely to cause UTIs. C. albicans, 25 C. tropicalis 26,27 and C. glabrata 19 have been, respectively, considered to be more associated with urinary infection in the different reports. Thus, the differentiation of Candida species distribution of urinary Candida colonization and infection is an issue worthy of discussion in future clinical research.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

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Background: Since urine cultures are only guaranteed for patients with obvious urinary symptoms in most cases, most of candiduria episodes are ignored in clinic. Objective: This study aimed to design a screening protocol to improve diagnostic efficiency of candiduria, and provide information of Candida species and drug susceptibility. Methods: All patients, who were admitted to the intensive care unit (ICU) of our hospital during December 1, 2018 and October 1, 2019, were enrolled in this study. Urinalysis was performed every three days for each subject from the first day of ICU admission. Urine specimens were sampled for fungal culture with either condition: (1) yeast-like cell counting (YLCC) ≥200; (2) positive YLCCs were observed in two consecutive tests, and at least one YLCC ≥100. Results: The screening protocol dramatically improved the candiduria diagnostic rate of ICU patients from 2.28% to 17.27%. However, compared to the historical control, the screening protocol has no time-saving advantage in candiduria diagnosing. Higher percentage of C. albicans in screening protocol-identified candiduria patients was observed, although there was no statistical difference. Our results indicated that female gender, pneumonia, diabetes and infarction/hemorrhage patients were more prone to develop candiduria. Non-candiduria patients showed a better tendency for survival and shorter ICU stay length. Multisite colonization was common in the surveyed candiduria patients, who were up to 70.83% showed Candida positive cultures in sputum. Conclusion: The screening protocol established in the study was a convenient and practical tool for early warning and feasible management of candiduria and IC.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

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“…(NACS) accounted for 62% of candiduria patient isolates in a study conducted by Abishek et al in 2019 [22]. Several studies have also shown that Candida tropicalis [23] and Candida glabrata [24] identified as the most isolated urinary tract Candida species, with a percentage of 37.6% and 50%, respectively, higher than C. albicans. This incident may have occurred because NACS is more adaptable to the urinary system and more resistant to azoles compared to C. albicans [24].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Risk Factors for Candiduria in Hospitalized Patients at Dr. Soetomo Hospital, Surabaya, Indonesia

Anggraeni¹,

Endraswari²,

Rusli³

et al. 2022

IJRP

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Background: Candiduria can represent a variety of conditions, from sample contamination, kidney and collecting system infections, to life-threatening disseminated candidiasis. The prevalence of candiduria is significantly higher in hospitalized patients and may be associated with an increased mortality rate. Until now, most candiduria research has been done in developed countries, while the prevalence varies widely in different parts of the world.Objective: This study aimed to determine the epidemiology and risk factors for candiduria in hospitalized patients at Dr. Soetomo Hospital Surabaya from January to December 2020. Methods: This study is an observational analytic study with a cross-sectional design using medical record data and a total sample of 301 samples consisting of 185 candiduria patients and 116 non-candiduria patients. Results: Among 185 candiduria patients, most patients were female (67.6%) and dominated by the age group 45-59 years (40.5%). Candida albicans was found most commonly (42.7%). No resistance of the studied Candida species to Amphotericin B was found. The prevalence of candiduria in hospitalized patients was 0.55%. Variables that had a significant relationship with candiduria were diabetes mellitus (p=0.005; PR=1.309; 95% CI=1.089-1.575), antibiotic use (p=0.006; PR=1.4; 95% CI=1.174-1.670), and the use of an Intraurethral Catheter (IUC) (p=0.008; PR=1.292; 95% CI=1.074-1.554). While old age, female gender, and corticosteroid therapy had no association with candiduria. Conclusion:The prevalence of candiduria is 0.55%. Diabetes mellitus, antibiotic use, and the use of an Intraurethral Catheter (IUC) have a significant relationship with candiduria in hospitalized patients.

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“…C. glabrata is an important causative agent with 19–48% of UTIs linked to this pathogen, especially when azole antifungals are used [ 31–38 ]. In mice, these infections develop in the bladder but rapidly progress into the kidneys and the spleen [ 26 ] congruent with kidney infection causing severe symptoms in humans, leading to high mortality [ 32 , 35 ]. Treatment is challenging, especially when the catheter cannot be removed.…”

Section: Introductionmentioning

confidence: 99%

Using in vivo transcriptomics and RNA enrichment to identify genes involved in virulence of Candida glabrata

et al. 2022

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Candida species are the most commonly isolated opportunistic fungal pathogens in humans. Candida albicans causes most of the diagnosed infections, closely followed by Candida glabrata . C. albicans is well studied, and many genes have been shown to be important for infection and colonization of the host. It is however less clear how C. glabrata infects the host. With the help of fungal RNA enrichment, we here investigated for the first time the transcriptomic profile of C. glabrata during urinary tract infection (UTI) in mice. In the UTI model, bladders and kidneys are major target organs and therefore fungal transcriptomes were addressed in these organs. Our results showed that, next to adhesins and proteases, nitrogen metabolism and regulation play a vital role during C. glabrata UTI. Genes involved in nitrogen metabolism were upregulated and among them we show that DUR1,2 (urea amidolyase) and GAP1 (amino acid permease) were important for virulence. Furthermore, we confirmed the importance of the glyoxylate cycle in the host and identified MLS1 (malate synthase) as an important gene necessary for C. glabrata virulence. In conclusion, our study shows with the support of in vivo transcriptomics how C. glabrata adapts to host conditions.

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Epidemiological profile of patients hospitalized with candiduria in the Central-Western region of Brazil

Cited by 6 publications

References 54 publications

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Epidemiology and Risk Factors for Candiduria in Hospitalized Patients at Dr. Soetomo Hospital, Surabaya, Indonesia

Using in vivo transcriptomics and RNA enrichment to identify genes involved in virulence of Candida glabrata

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