Epidemiological profile in multiple sclerosis patients, Uberaba, MG, Brazil

Abstract

about the epidemiological characteristics of patients with multiple sclerosis (MS) in the city of Uberaba-MG, Brazil. In this article, the authors comment on the similarity of most of the clinical and epidemiological features found in Uberaba to those presented in other samples in Brazil. However, when considering ethnicity, which in their study was predominantly Caucasian (85.71%), they cite the example of the city of Recife, where the incidence was predominantly in the black population (93.3%). They also mention the difficulties of ethnic classification in the Brazilian population, given the racial characteristics observed in our population.We agree that these difficulties exist but, nonetheless, we believe that ethnic traits need to be better studied in Brazil, with regard to the therapeutic options for multiple sclerosis. This can be seen from a study by Alves-Leon et al. 1 , in which they demonstrated the existence of heterogeneous phenotypes of HLA-DRB1*1501 in a population of healthy Brazilians that included both African descendants and white subjects. It is known that these alleles can negatively influence the therapeutic response to interferon. In another study, Brum et al. 2 drew attention to the fact that HLA-DRB1 may exhibit behavior of either resistance or susceptibility in response to ethnic background and environmental factors.Brazil is a country of continental dimensions with a high degree of miscegenation. However, this miscegenation is variable with regard to demographic distribution. Ethnic characteristics need to be reviewed more carefully because surveys on the epidemiology of MS in some Brazilian cities have found that the rate of cases of MS among the black population was greater than that observed in other studies, especially in the cities of Rio de Janeiro (28%) 3 and Cuiabá (26%) 4,5 . This implies that there is a need for regional and multicenter studies on MS in Brazil, especially in relation to the genetic susceptibility and environmental variables observed in a country with the dimensions of Brazil.Our congratulations to the authors. Perfil clínico e evolutivo no município do Rio de Janeiro. Rev Bras Neurol 1995;31:75-87. 4. Grzesiuk AK. Características clínicas e epidemiológicas de 20 portadores de esclerose múltipla acompanhados em Cuiabá-Mato Grosso. Arq

Associação entre esclerose múltipla e alelos hla-drb1* em uma população miscigenada de Salvador, Ba, Brasil

“…Indivíduos das raças/etnias branca e mulata que apresentam maiores prevalências dos alelos HLA--DRB1*15 são mais suscetíveis à EM 9,32,44 . A avaliação do perfil alélico segundo a raça/etnia realizada neste estudo permite inferir que ao associá-lo com o risco em desenvolver a EM os afrodescendentes apresentavam uma susceptibilidade que dependia de sua composição alélica, predominantemente HLA-DRB1*15 e HLA--DRB1*07.…”