Epidemiological Investigation of Urolithiasis in Israel

M, Frank; Vries, A. De; Atsmon, A; Lazebnik, J.; Kochwa, Shaul

doi:10.1016/s0022-5347(17)66053-1

Cited by 58 publications

(16 citation statements)

References 9 publications

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“…However, urinary calcium concentrations may rise significantly above this value when water intake is restricted since increases in arginine vasopressin (AVP) 1 -elicited osmotic water permeability (P f ) in collecting duct stimulate water reabsorption selectively via aquaporin 2 (AQP-2) water channels. Intervals of antidiuresis have been implicated in both the increased incidence of nephrolithiasis in hot dry regions (5) as well as the substantial risk of recurrent stone formation in patients with nephrolithiasis (6).…”

Section: Introductionmentioning

confidence: 99%

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

et al. 1997

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During antidiuresis, increases in vasopressin (AVP)-elicited osmotic water permeability in the terminal inner medullary collecting duct (tIMCD) raise luminal calcium concentrations to levels ( Ն 5 mM) above those associated with the formation of calcium-containing precipitates in the urine. Calcium/polycation receptor proteins (CaRs) enable cells in the parathyroid gland and kidney thick ascending limb of Henle to sense and respond to alterations in serum calcium. We now report the presence of an apical CaR in rat kidney tIMCD that specifically reduces AVP-elicited osmotic water permeability when luminal calcium rises. Purified tIMCD apical membrane endosomes contain both the AVP-elicited water channel, aquaporin 2, and a CaR. In addition, aquaporin 2-containing endosomes also possess stimulatory (G ␣ q / G ␣ 11 ) and inhibitory (G ␣ i1, 2, and 3 ) GTP binding proteins reported previously to interact with CaRs as well as two specific isoforms (delta and zeta) of protein kinase C.Immunocytochemistry using anti-CaR antiserum reveals the presence of CaR protein in both rat and human collecting ducts. Together, these data provide support for a unique tIMCD apical membrane signaling mechanism linking calcium and water metabolism. Abnormalities in this mechanism could potentially play a role in the pathogenesis of renal stone formation. ( J. Clin. Invest. 1997. 99:1399-1405.)

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Section: Introductionmentioning

confidence: 99%

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

et al. 1997

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“…Tables II and III present the incidence of urolithiasis accord ing to the origin of the population. The division between the immi grants from Europe and those from the Middle East and North Africa, is based upon ethnic differences, as discussed in our previous communication (1). In the present study two additional groups, South Americans and Indians were singled out because of their special customs and remarkably low incidence of urolithiasis.…”

Section: Observationsmentioning

confidence: 69%

“…The present survey covered 28 settlements with a population of 10824 ( logical data and composition of drinking water, see previous report ( 1).…”

Section: Methodsmentioning

confidence: 99%

“…The highest incidence was found in settlements located in the hotter parts of the area screened. Low urine output, due to inadequacy of fluid intake relative to the large extrarenal fluid loss, was postulated to be the chief cause of the high incidence of urolithiasis (1). In order to obtain further evidence for this supposition, the epidemiological study was extended to cover the recently settled Southern region of Israel, the Negev, which has a hot and arid climate.…”

Section: Epidemiologische Untersuchung üBer Die Urolithiasis Im Heißementioning

confidence: 99%

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Epidemiological Investigation of Urolithiasis in the Hot Arid Southern Region of Israel

M¹,

Atsmon²,

Sugar³

et al. 1963

Urol Int

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“…Decrease in urinary volume is considered a cause of lithiasis (9). In hot climate countries extrarenal losses and low fluids intake can contribute to stone formation.…”

Section: Discussionmentioning

confidence: 99%

Metabolic investigation of patients with urolithiasis in a specific region

2003

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Objective: To assess the prevalence of the main metabolic alterations found in patients with recent diagnosis of urolithiasis in the West region of Paraná state, Brazil.Materials and Methods: We made a retrospective study on 425 patients with evidence of recent formation of renal stones. Laboratory assessment consisted in 3 samples of 24-hour urine with dosing of calcium, uric acid, citrate, oxalate, sodium and creatinine. A urine culture was also made and qualitative cystinuria and urinary pH following 12-hour fasting and water restriction were evaluated.Results: In 96.5% of patients a cause was detected for the urolithiasis. Metabolic alterations most frequently found were: hypercalciuria (38.3%), hypocitraturia (29.6%) and hyperexcretion of uric acid (21.6%). Low urinary volume (17.9%), urinary tract infection (12.9%), hyperparathyroidism (3.3%), renal tubular acidosis (1.2%), cystinuria (0.9%) and anatomical alterations (12.7%) were also observed.Conclusions: Hypercalciuria, hypocitraturia and hyperuricuria are the most frequent metabolic disorders in the population under study and these data are in accordance to the literature.

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Epidemiological Investigation of Urolithiasis in Israel

Cited by 58 publications

References 9 publications

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

Epidemiological Investigation of Urolithiasis in the Hot Arid Southern Region of Israel

Metabolic investigation of patients with urolithiasis in a specific region

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