“…Consistent with previous data, we found an annual incidence rate of 0.24 per 100,000, which is lower than that observed in Iran (29), Spain (30), and Greece (31), where the annual incidence rates are 0.58 per 100,000, 0.66 per 100,000, and 4 per 100,000, respectively. With regard to the clinical features of BD, in our population the age at diagnosis and the frequency of the specific clinical manifestations were similar to those observed in other European countries and in a previous hospital-based multicenter Italian study (6,32). In particular, we did not observe a significant preponderance of men, and the onset of BD at Ͻ16 years of age was exceptional.…”