Epidemiological Features and Clinical Study of Kawasaki Disease in Iran

Akbariasbagh, Parvin; Talebiyan, Saharnaz; Aghighi, Yahya; Raeeskarami, Reza; Seyedhoseinpour, Amirhosein; Tabrizi, Ali

doi:10.18502/acta.v58i12.5154

Cited by 4 publications

(4 citation statements)

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“…| 3 of 8 Gender as a neonatal factor has been reported to have a significant effect on the type and presence of CHD so it can be considered a risk factor. 22,23 Our results show that the ratio of male to female neonates is 2.6, which means that CHD is more prevalent in male infants. The prevalence of male patients ranged from 45% to 73% of all conditions in the present study.…”

Section: Discussionmentioning

confidence: 63%

Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran

Parvar

Ghaderpanah

Naghshzan

2023

Health Science Reports

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Introduction Congenital heart disease (CHD), the lethal congenital anomaly in newborns, is multifactorial, with environmental and genetic factors contributing to its occurrence. Although some studies on the prevalence of CHD have been conducted throughout the country, this large‐scale study aims to provide information on the prevalence of various types of CHDs in newborns according to the echocardiography findings. Patients and Methods Over 3 years, 8145 neonates with suspected CHD who underwent echocardiography by a trained pediatric cardiologist were included in this multicenter, cross‐sectional observational study. CHD was categorized into two major groups; cyanotic and acyanotic heart disease. The SPSS version 22 software was used to analyze the data with a significance level set at 0.05. Results Of 8145 neonates who were referred to our centers with CHD symptoms, 6307 were indicated for echocardiography. The mean age of the studied population was 8.5 ± 9.3 days and the male‐to‐female ratio was 2.6, especially in the arterial septal defect (ASD), ventricular septal defect (VSD), and patent ductus arteriosus (PDA) groups. 77.2% of patients had acyanotic heart disease (100 in 1000 neonates) with ASD as the most common one and 9% were diagnosed with cyanotic heart disease (11 in 1000 neonates) with transposition of the great arteries as the most common form and the aortopulmonary window was the rarest form. Conclusion This large prospective, multicenter screening study reported arterial septal defect (85%) and patents with ductus arteriosus (32%) as the most frequent type of CHD. Moreover, the prevalence of male patients was significantly higher. This information would be helpful for health policy makers, stakeholders, and general practitioners in regions where there are no trained pediatric cardiologist fellowships and limited access to echocardiography devices for better management of CHD.

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Section: Discussionmentioning

confidence: 63%

Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran

Parvar

Ghaderpanah

Naghshzan

2023

Health Science Reports

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“…15 A retrospective study done by Akbariasbagh et al from Iran found overall prevalence of cardiovascular anomalies among IDMs as 30% which is higher than what was noted in this study (20.0%). 16 Dimitriu et al shared that cardiac abnormalities were noted in 23% of the IDMs, without being affected by pulmonary hypertension and HCM. 17 Schafer et al mentioned in their study that the occurrence of cardiovascular anomalies among all other anomalies was 37.6%.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular anomalies in infants born to diabetic mothers: A study at a Tertiary Care Hospital.

Liaqat¹,

Riaz

Korejo

et al. 2023

TPMJ

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Objective: To find out the frequency of cardiovascular anomalies in infants born to diabetic mothers (IDMs). Study Design: Case-control study. Setting: Department of Pediatric Medicine and the Department of Obstetrics & Gynecology, Rai Medical College / Teaching Hospital, Sargodha. Period: January 2022 to December 2022. Material & Methods: A total of 50 term IDMs were enrolled in case group while equal number of healthy infants (n=50) were enrolled as controls. All mothers received prenatal care. Standard diagnostic criteria were followed for labeling diabetes and gestational diabetes. All infants underwent detailed physical and clinical examination. Demographic and maternal characteristics along with perinatal and maternal information were noted. All infants underwent echocardiographic evaluation. Results: In a total of 100 infants, 51 (51.0%) were boys and 49 (49.0%) girls. The mean birth weight, Apgar score (at 5-minutes), maternal age and gestational age were 2.84±1.8 kg, 8.8±0.7, 29.5±3.2 and 37.4±1.8 weeks respectively. Maternal hypertension was observed among 12 (12.0%) subjects. Birth weight (p<0.0001), maternal age (p=0.0129) and gestational age (p=0.0110) were significantly higher among cases while Apgar score was significantly lower among cases in comparison to controls (p=0.0028). Cardiovascular anomalies were diagnosed in 10 (20.0%) cases in comparison to 3 (6.0%) controls and the difference was found to be statistically significant. Among IDMs, hypertrophic cardiomyopathy (HCM) was the most frequent cardiovascular anomaly, noted in 4 (8.0%) cases. Conclusion: The frequency of cardiovascular anomalies was significantly high among IDMs in comparison to infants born to non-diabetic mothers. IDMs should undergo cardiac examination to rule out the possibility of existing cardiovascular anomalies.

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“…Babies exposed to maternal hyperglycemia have an increased risk of congenital heart structural anomalies, heart morphological changes and dysfunction, including congenital heart disease, [1][2][3] cardiac hypertrophy in embryonic hearts, 4 impaired cardiac diastolic function in the fetuses 5 and early-onset cardiovascular disease in childhood or early adulthood. 6 However, the molecular mechanisms responsible for the disruption of normal heart development in the offspring of mothers with diabetes have not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of miR-21-5p rescues the inhibition of cardiomyocyte proliferation induced by high glucose through negative regulation of Rhob

Wu,

Wang,

Yang

et al. 2023

J Dev Orig Health Dis

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Increasing evidence shows that maternal hyperglycemia inhibits cardiomyocyte (CM) proliferation and promotes cell apoptosis during fetal heart development, which leads to cardiac dysplasia. Accumulating evidence suggests that the overexpression of miR-21 in CMs has a protective role in cardiac function. Therefore, we investigated whether miR-21 can rescue CM injury caused by high glucose. First, we performed biological function analysis of miR-21-5p overexpression in H9c2 cells treated with high glucose. We found that the proliferation of H9c2 cells treated with high glucose decreased significantly and was rescued after overexpression of miR-21-5p. CCK-8 and EdU incorporation assays were performed to assess cell proliferation. The cell proliferation of the miR-21-5p mimic transfection group was improved compared with that of the NC mimic group (*p < 0.05, miR-21-5p mimics vs. NC mimics) when the proliferation of H9c2 cells was reduced by high glucose (****p < 0.0001, high glucose (HG) vs. normal glucose (NG)). Then, we verified the targeted and negative regulation of miR-21-5p on Rhob using a dual-luciferase activity assay and RT-qPCR, respectively. We further demonstrated that miR-21-5p regulates Rhob to rescue the inhibition of CM proliferation induced by high glucose. The CCK-8 results showed that the cell proliferation of the siRNA-Rhob group was higher than that of the NC mimic group (***p < 0.001) and that of the cotransfection group with Up-Rhob plasmids and miR-21-5p mimics was lower than that of the miR-21-5p mimic group (*p < 0.05). Conclusion: Overexpression of miR-21-5p rescues the inhibition of high glucose-induced CM proliferation through regulation of Rhob.

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Epidemiological Features and Clinical Study of Kawasaki Disease in Iran

Cited by 4 publications

References 0 publications

Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran

Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran

Cardiovascular anomalies in infants born to diabetic mothers: A study at a Tertiary Care Hospital.

Upregulation of miR-21-5p rescues the inhibition of cardiomyocyte proliferation induced by high glucose through negative regulation of Rhob

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